General Structure Information
| PDB ID | 3rn5 |
| HGNC Gene Label(s) | AIM2 |
| Structure Name | structural basis of cytosolic dna recognition by innate immune receptors |
| Resolution | 2.5Å |
| Reference | AUTH T.JIN,A.PERRY,J.JIANG,P.SMITH,J.A.CURRY,L.UNTERHOLZNER,AUTH 2 Z.JIANG,G.HORVATH,V.A.RATHINAM,R.W.JOHNSTONE,V.HORNUNG,AUTH 3 E.LATZ,A.G.BOWIE,K.A.FITZGERALD,T.S.XIAOTITL STRUCTURES OF THE HIN DOMAIN:DNA COMPLEXES REVEAL LIGANDTITL 2 BINDING AND ACTIVATION MECHANISMS OF THE AIM2 INFLAMMASOMETITL 3 AND IFI16 RECEPTOR.REF IMMUNITY V. 36 561 2012REFN ISSN 1074-7613PMID 22483801DOI 10.1016/J.IMMUNI.2012.02.014 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 194 |
| Number Of SNVs | 40 |
| Number Of Permutations | 5707 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.013 |
| p-value | 0.714 |
COSMIC
| Number Of Residues | 194 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2560 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.9 |
| p-value | 0.501 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 40 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.287 |
| p-value | 0.789 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
