Assessment of Structural Intolerance and Durability
General Structure Information 3hei EFNA1 ligand recognition by a-class eph receptors: crystal structures of the epha2 ligand-binding domain and the epha2/ephrin-a1 complex 2.0Å AUTH J.P.HIMANEN,Y.GOLDGUR,H.MIAO,E.MYSHKIN,H.GUO,M.BUCK,AUTH 2 M.NGUYEN,K.R.RAJASHANKAR,B.WANG,D.B.NIKOLOVTITL LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTALTITL 2 STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THETITL 3 EPHA2/EPHRIN-A1 COMPLEX.REF EMBO REP. V. 10 722 2009REFN ISSN 1469-221XPMID 19525919DOI […]
General Structure Information 3kq4 GIF structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Mapped Variants
General Structure Information 3h5c PROZ x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Mapped Variants
General Structure Information 3h6a ITGB4 structure of the calx-beta domain of integrin beta4 crystallized in the presence of calcium 1.61Å AUTH N.ALONSO-GARCIA,A.INGLES-PRIETO,A.SONNENBERG,AUTH 2 J.M.DE PEREDATITL STRUCTURE OF THE CALX-BETA DOMAIN OF THE INTEGRINTITL 2 BETA4 SUBUNIT: INSIGHTS INTO FUNCTION ANDTITL 3 CATION-INDEPENDENT STABILITYREF ACTA CRYSTALLOGR.,SECT.D V. 65 858 2009REFN ISSN 0907-4449PMID 19622870DOI 10.1107/S0907444909018745 Variant Set […]
General Structure Information 3igu NAGA crystal structure of human alpha-n-acetylgalactosaminidase, covalent intermediate 2.15Å AUTH N.E.CLARK,S.C.GARMANTITL THE 1.9 A STRUCTURE OF HUMANTITL 2 ALPHA-N-ACETYLGALACTOSAMINIDASE: THE MOLECULAR BASIS OFTITL 3 SCHINDLER AND KANZAKI DISEASESREF J.MOL.BIOL. V. 393 435 2009REFN ISSN 0022-2836PMID 19683538DOI 10.1016/J.JMB.2009.08.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2jxd SPINK2 nmr structure of human serine protease inhibitor kazal type ii (spink2) -1.0Å AUTH T.CHEN,T.-R.LEE,W.-G.LIANG,W.-S.W.CHANG,P.-C.LYUTITL IDENTIFICATION OF TRYPSIN-INHIBITORY SITE ANDTITL 2 STRUCTURE DETERMINATION OF HUMAN SPINK2 SERINETITL 3 PROTEINASE INHIBITORREF PROTEINS V. 77 209 2009REFN ISSN 0887-3585PMID 19422058DOI 10.1002/PROT.22432 Variant Set Distributions Mapped Variants
General Structure Information 2ksr CHRNB2 nmr structures of tm domain of the n-acetylcholine receptor b2 subunit -1.0Å AUTH V.BONDARENKO,T.TILLMAN,Y.XU,P.TANGTITL NMR STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THETITL 2 N-ACETYLCHOLINE RECEPTOR BETA2 SUBUNIT.REF BIOCHIM.BIOPHYS.ACTA V.1798 1608 2010REFN ISSN 0006-3002PMID 20441771DOI 10.1016/J.BBAMEM.2010.04.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lpo SI crystal structure of the n-terminal domain of sucrase-isomaltase 3.2Å AUTH L.SIM,C.WILLEMSMA,S.MOHAN,H.Y.NAIM,B.M.PINTO,D.R.ROSETITL STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN HUMANTITL 2 MALTASE-GLUCOAMYLASE AND SUCRASE-ISOMALTASE N-TERMINALTITL 3 DOMAINS.REF J.BIOL.CHEM. V. 285 17763 2010REFN ISSN 0021-9258PMID 20356844DOI 10.1074/JBC.M109.078980 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3idv PDIA4 crystal structure of the a0a fragment of erp72 1.95Å AUTH G.KOZLOV,S.AZEROUAL,A.ROSENAUER,P.MAATTANEN,A.Y.DENISOV,AUTH 2 D.Y.THOMAS,K.GEHRINGTITL STRUCTURE OF THE CATALYTIC A(0)A FRAGMENT OF THE PROTEINTITL 2 DISULFIDE ISOMERASE ERP72.REF J.MOL.BIOL. V. 401 618 2010REFN ISSN 0022-2836PMID 20600112DOI 10.1016/J.JMB.2010.06.045 Variant Set Distributions Mapped Variants