Assessment of Structural Intolerance and Durability
General Structure Information 3f1p ARNT crystal structure of a high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains 1.17Å AUTH T.H.SCHEUERMANN,D.R.TOMCHICK,M.MACHIUS,Y.GUO,AUTH 2 R.K.BRUICK,K.H.GARDNERTITL ARTIFICIAL LIGAND BINDING WITHIN THE HIF2ALPHATITL 2 PAS-B DOMAIN OF THE HIF2 TRANSCRIPTION FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 106 450 2009REFN ISSN 0027-8424PMID 19129502DOI 10.1073/PNAS.0808092106 Variant Set Distributions Mapped Variants
General Structure Information 3bk3 BMP2 crystal structure of the complex of bmp-2 and the first von willebrand domain type c of crossveinless-2 2.7Å AUTH J.-L.ZHANG,L.-Y.QIU,A.KOTZSCH,S.WEIDAUER,AUTH 2 L.PATTERSON,M.HAMMERSCHMIDT,W.SEBALD,T.D.MUELLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS HOW THE CHORDINTITL 2 FAMILY MEMBER CROSSVEINLESS 2 BLOCKS BMP-2TITL 3 RECEPTOR BINDINGREF DEV.CELL V. 14 739 2008REFN ISSN 1534-5807PMID 18477456DOI 10.1016/J.DEVCEL.2008.02.017 Variant Set […]
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2j0f TYMP structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design 2.31Å AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 Variant Set Distributions Ripley’s K […]
General Structure Information 3hng FLT1 crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide 2.7Å AUTH L.TRESAUGUES,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,T.NYMAN,C.PERSSON,T.KRAGH-NIELSEN,AUTH 5 A.KOTZCH,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,S.VAN DER BERG,J.WEIGELT,M.WELIN,AUTH 7 M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITHTITL 2 N-(4-CHLOROPHENYL)-2-((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3fji FGF1 crystal structure of k12v/c83i/c117v mutant of human acidic fibroblast growth factor 2.55Å AUTH J.LEE,M.BLABERTITL STRUCTURAL BASIS OF CONSERVED CYSTEINE IN THETITL 2 FIBROBLAST GROWTH FACTOR FAMILY: EVIDENCE FOR ATITL 3 VESTIGIAL HALF-CYSTINE.REF J.MOL.BIOL. V. 393 128 2009REFN ISSN 0022-2836PMID 19683004DOI 10.1016/J.JMB.2009.08.007 Variant Set Distributions Mapped Variants
General Structure Information 2v70 SLIT2 third lrr domain of human slit2 3.01Å AUTH C.MORLOT,W.HEMRIKA,R.A.ROMIJN,P.GROS,S.CUSACK,A.A.MCCARTHYTITL PRODUCTION OF SLIT2 LRR DOMAINS IN MAMMALIAN CELLS FORTITL 2 STRUCTURAL STUDIES AND THE STRUCTURE OF HUMAN SLIT2 DOMAINTITL 3 3.REF ACTA CRYSTALLOGR.,SECT.D V. 63 961 2007REFN ISSN 0907-4449PMID 17704564DOI 10.1107/S0907444907035470 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2qqk NRP2 neuropilin-2 a1a2b1b2 domains in complex with a semaphorin-blocking fab 2.75Å AUTH B.A.APPLETON,P.WU,J.MALONEY,J.YIN,W.C.LIANG,S.STAWICKI,AUTH 2 K.MORTARA,K.K.BOWMAN,J.M.ELLIOTT,W.DESMARAIS,J.F.BAZAN,AUTH 3 A.BAGRI,M.TESSIER-LAVIGNE,A.W.KOCH,Y.WU,R.J.WATTS,C.WIESMANNTITL STRUCTURAL STUDIES OF NEUROPILIN/ANTIBODY COMPLEXES PROVIDETITL 2 INSIGHTS INTO SEMAPHORIN AND VEGF BINDINGREF EMBO J. V. 26 4902 2007REFN ISSN 0261-4189PMID 17989695DOI 10.1038/SJ.EMBOJ.7601906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3edi TLL1 crystal structure of tolloid-like protease 1 (tll-1) protease domain 1.4Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wfh SLIT2 the human slit 2 dimerization domain d4 1.8Å AUTH E.SEIRADAKE,A.C.VON PHILIPSBORN,M.HENRY,M.FRITZ,AUTH 2 H.LORTAT-JACOB,M.JAMIN,W.HEMRIKA,M.BASTMEYER,S.CUSACK,AUTH 3 A.A.MCCARTHYTITL STRUCTURE AND FUNCTIONAL RELEVANCE OF THE SLIT2TITL 2 HOMODIMERIZATION DOMAIN.REF EMBO REP. V. 10 736 2009REFN ISSN 1469-221XPMID 19498462DOI 10.1038/EMBOR.2009.95 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants