Assessment of Structural Intolerance and Durability
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 3bhh CAMK2B crystal structure of human calcium/calmodulin-dependent protein kinase iib isoform 1 (camk2b) 2.4Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,F.NIESEN,N.BURGESS,A.BULLOCK,AUTH 2 G.BERRIDGE,A.C.W.PIKE,E.UGOCHUKWU,E.S.PILKA,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE IIB ISOFORM 1 (CAMK2B).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ee1 CHD4 solution structures of the chromo domain of human chromodomain helicase-dna-binding protein 4 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE CHROMO DOMAIN OF HUMANTITL 2 CHROMODOMAIN HELICASE-DNA-BINDING PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1unl CDK5 structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin. 2.2Å AUTH M.MAPELLI,L.MASSIMILINAO,C.CROVACE,M.A.SEELIGER,L.-H.TSAI,AUTH 2 L.MEIJER,A.MUSACCHIOTITL MECHANISM OF CDK5/P25 BINDING BY CDK INHIBITORSREF J.MED.CHEM. V. 48 671 2005REFN ISSN 0022-2623PMID 15689152DOI 10.1021/JM049323M Variant Set Distributions Mapped Variants
General Structure Information 1unl CDK5 structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin. 2.2Å AUTH M.MAPELLI,L.MASSIMILINAO,C.CROVACE,M.A.SEELIGER,L.-H.TSAI,AUTH 2 L.MEIJER,A.MUSACCHIOTITL MECHANISM OF CDK5/P25 BINDING BY CDK INHIBITORSREF J.MED.CHEM. V. 48 671 2005REFN ISSN 0022-2623PMID 15689152DOI 10.1021/JM049323M Variant Set Distributions Mapped Variants
General Structure Information 1bi8 CDK6 mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1bi8 CDKN2D mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Mapped Variants