Assessment of Structural Intolerance and Durability
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 1wf6 TOPBP1 the third brca1 c-terminus (brct) domain of similar to s.pombe rad4+/cut5+ product -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE THIRD BRCA1 C-TERMINUS (BRCT) DOMAIN OFTITL 2 SIMILAR TO S.POMBE RAD4+/CUT5+ PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pd7 TOPBP1 crystal structure of the sixth brct domain of human topbp1 1.26Å AUTH J.LEE,C.XU,G.CUI,J.R.THOMPSON,G.MERTITL CRYSTAL STRUCTURE OF THE SIXTH BRCT DOMAIN OF HUMAN TOPBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2xoc CHFR c-terminal cysteine-rich domain of human chfr bound to madpr 1.89Å AUTH J.OBEROI,M.W.RICHARDS,S.CRUMPLER,N.BROWN,J.BLAGG,AUTH 2 R.BAYLISSTITL STRUCTURAL BASIS OF POLY(ADP-RIBOSE) RECOGNITIONTITL 2 BY THE MULTIZINC BINDING DOMAIN OF CHECKPOINT WITHTITL 3 FORKHEAD-ASSOCIATED AND RING DOMAINS (CHFR).REF J.BIOL.CHEM. V. 285 39348 2010REFN ISSN 0021-9258PMID 20880844DOI 10.1074/JBC.M110.159855 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2ovq FBXW7 structure of the skp1-fbw7-cyclinedegc complex 2.6Å AUTH B.HAO,S.OEHLMANN,M.E.SOWA,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF A FBW7-SKP1-CYCLIN E COMPLEX:TITL 2 MULTISITE-PHOSPHORYLATED SUBSTRATE RECOGNITION BY SCFTITL 3 UBIQUITIN LIGASESREF MOL.CELL V. 26 131 2007REFN ISSN 1097-2765PMID 17434132DOI 10.1016/J.MOLCEL.2007.02.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4c9y SKA1 structural basis for the microtubule binding of the human kinetochore ska complex 2.01Å AUTH M.A.ABAD,B.MEDINA,A.SANTAMARIA,J.ZOU,C.PLASBERG-HILL,AUTH 2 A.MADHUMALAR,U.JAYACHANDRAN,P.M.REDLI,J.RAPPSILBER,E.A.NIGG,AUTH 3 A.A.JEYAPRAKASHTITL STRUCTURAL BASIS FOR MICROTUBULE RECOGNITION BY THE HUMANTITL 2 KINETOCHORE SKA COMPLEX.REF NAT.COMMUN. V. 5 2964 2014REFN ISSN 2041-1723PMID 24413531DOI 10.1038/NCOMMS3964 Variant Set Distributions Mapped Variants
General Structure Information 4aj5 SKA3 crystal structure of the ska core complex 3.32Å AUTH A.A.JEYAPRAKASH,A.SANTAMARIA,U.JAYACHANDRAN,Y.W.CHAN,AUTH 2 C.BENDA,E.A.NIGG,E.CONTITITL STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE SKA COMPLEX,TITL 2 A KEY COMPONENT OF THE KINETOCHORE-MICROTUBULE INTERFACE.REF MOL.CELL V. 46 274 2012REFN ISSN 1097-2765PMID 22483620DOI 10.1016/J.MOLCEL.2012.03.005 Variant Set Distributions Mapped Variants
General Structure Information 2yrh ZNF473 solution structure of the c2h2-type zinc finger domain (699- 729) from zinc finger protein 473 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2-TYPE ZINC FINGERTITL 2 DOMAIN (699-729) FROM ZINC FINGER PROTEIN 473REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3hmh TAF1L crystal structure of the second bromodomain of human tbp-associated factor rna polymerase 1-like (taf1l) 2.05Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3gni STRADA structure of strad and mo25 2.35Å AUTH E.ZEQIRAJ,B.M.FILIPPI,S.GOLDIE,I.NAVRATILOVA,J.BOUDEAU,AUTH 2 M.DEAK,D.R.ALESSI,D.M.VAN AALTENTITL ATP AND MO25ALPHA REGULATE THE CONFORMATIONAL STATE OF THETITL 2 STRADALPHA PSEUDOKINASE AND ACTIVATION OF THE LKB1 TUMOURTITL 3 SUPPRESSORREF PLOS BIOL. V. 7 E1000 2009REFN ISSN 1544-9173PMID 19513107DOI 10.1371/JOURNAL.PBIO.1000126 Variant Set Distributions Mapped Variants