Assessment of Structural Intolerance and Durability
General Structure Information 2q8h PDK1 structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) 2.0Å AUTH M.KATO,J.LI,J.L.CHUANG,D.T.CHUANGTITL DISTINCT STRUCTURAL MECHANISMS FOR INHIBITION OF PYRUVATETITL 2 DEHYDROGENASE KINASE ISOFORMS BY AZD7545, DICHLOROACETATE,TITL 3 AND RADICICOL.REF STRUCTURE V. 15 992 2007REFN ISSN 0969-2126PMID 17683942DOI 10.1016/J.STR.2007.07.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3pe0 PLEC structure of the central region of the plakin domain of plectin 2.95Å AUTH E.ORTEGA,R.M.BUEY,A.SONNENBERG,J.M.DE PEREDATITL THE STRUCTURE OF THE PLAKIN DOMAIN OF PLECTIN REVEALS ATITL 2 NON-CANONICAL SH3 DOMAIN INTERACTING WITH ITS FOURTHTITL 3 SPECTRIN REPEAT.REF J.BIOL.CHEM. V. 286 12429 2011REFN ISSN 0021-9258PMID 21288893DOI 10.1074/JBC.M110.197467 Variant Set Distributions Ripley’s K […]
General Structure Information 2c5d GAS6 structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vr2 DPYS human dihydropyrimidinase 2.8Å AUTH M.WELIN,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,M.D.HERMAN,I.JOHANSSON,AUTH 4 A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vr2 DPYS human dihydropyrimidinase 2.8Å AUTH M.WELIN,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,M.D.HERMAN,I.JOHANSSON,AUTH 4 A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vr2 DPYS human dihydropyrimidinase 2.8Å AUTH M.WELIN,T.KARLBERG,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,AUTH 3 A.FLORES,S.GRASLUND,M.HAMMARSTROM,M.D.HERMAN,I.JOHANSSON,AUTH 4 A.KALLAS,T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL THE CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lv2 HNF4G hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids 2.7Å AUTH G.B.WISELY,A.B.MILLER,R.G.DAVIS,A.D.JR THORNQUEST,R.JOHNSON,AUTH 2 T.SPITZER,A.SEFLER,B.SHEARER,J.T.MOORE,T.M.WILLSON,AUTH 3 S.P.WILLIAMSTITL HEPATOCYTE NUCLEAR FACTOR 4 IS A TRANSCRIPTION FACTOR THATTITL 2 CONSTITUTIVELY BINDS FATTY ACIDS.REF STRUCTURE V. 10 1225 2002REFN ISSN 0969-2126PMID 12220494DOI 10.1016/S0969-2126(02)00829-8 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3rep ILK crystal structure of the ilk/alpha-parvin core complex (mnatp) 1.8Å AUTH K.FUKUDA,J.QINTITL CRYSTAL STRUCTURE OF THE ILK/ALPHA-PARVIN CORE COMPLEXTITL 2 (MNATP)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1v5w DMC1 crystal structure of the human dmc1 protein 3.2Å AUTH T.KINEBUCHI,W.KAGAWA,R.ENOMOTO,K.TANAKA,K.MIYAGAWA,AUTH 2 T.SHIBATA,H.KURUMIZAKA,S.YOKOYAMATITL STRUCTURAL BASIS FOR OCTAMERIC RING FORMATION AND DNATITL 2 INTERACTION OF THE HUMAN HOMOLOGOUS-PAIRING PROTEIN DMC1REF MOL.CELL V. 14 363 2004REFN ISSN 1097-2765PMID 15125839DOI 10.1016/S1097-2765(04)00218-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1v5w DMC1 crystal structure of the human dmc1 protein 3.2Å AUTH T.KINEBUCHI,W.KAGAWA,R.ENOMOTO,K.TANAKA,K.MIYAGAWA,AUTH 2 T.SHIBATA,H.KURUMIZAKA,S.YOKOYAMATITL STRUCTURAL BASIS FOR OCTAMERIC RING FORMATION AND DNATITL 2 INTERACTION OF THE HUMAN HOMOLOGOUS-PAIRING PROTEIN DMC1REF MOL.CELL V. 14 363 2004REFN ISSN 1097-2765PMID 15125839DOI 10.1016/S1097-2765(04)00218-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]