Assessment of Structural Intolerance and Durability
General Structure Information 2hi4 CYP1A2 crystal structure of human microsomal p450 1a2 in complex with alpha-naphthoflavone 1.95Å AUTH S.SANSEN,J.K.YANO,R.L.REYNALD,G.A.SCHOCH,AUTH 2 K.J.GRIFFIN,C.D.STOUT,E.F.JOHNSONTITL ADAPTATIONS FOR THE OXIDATION OF POLYCYCLICTITL 2 AROMATIC HYDROCARBONS EXHIBITED BY THE STRUCTURETITL 3 OF HUMAN P450 1A2.REF J.BIOL.CHEM. V. 282 14348 2007REFN ISSN 0021-9258PMID 17311915DOI 10.1074/JBC.M611692200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1ain ANXA1 crystal structure of human annexin i at 2.5 angstroms resolution 2.5Å AUTH X.WENG,H.LUECKE,I.S.SONG,D.S.KANG,S.H.KIM,R.HUBERTITL CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ATITL 2 RESOLUTION.REF PROTEIN SCI. V. 2 448 1993REFN ISSN 0961-8368PMID 8453382 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fo0 ABL1 organization of the sh3-sh2 unit in active and inactive forms of the c-abl tyrosine kinase 2.27Å AUTH B.NAGAR,O.HANTSCHEL,M.SEELIGER,J.M.DAVIES,W.I.WEIS,AUTH 2 G.SUPERTI-FURGA,J.KURIYANTITL ORGANIZATION OF THE SH3-SH2 UNIT IN ACTIVE AND INACTIVETITL 2 FORMS OF THE C-ABL TYROSINE KINASE.REF MOL.CELL V. 21 787 2006REFN ISSN 1097-2765PMID 16543148DOI 10.1016/J.MOLCEL.2006.01.035 Variant Set Distributions Ripley’s K […]
General Structure Information 4f0i NTRK1 crystal structure of apo trka 2.3Å AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1c9y OTC human ornithine transcarbamylase: crystallographic insights into substrate recognition and catalytic mechanism 1.9Å AUTH D.SHI,H.MORIZONO,M.AOYAGI,M.TUCHMAN,N.M.ALLEWELLTITL CRYSTAL STRUCTURE OF HUMAN ORNITHINE TRANSCARBAMYLASETITL 2 COMPLEXED WITH CARBAMOYL PHOSPHATE AND L-NORVALINE AT 1.9 ATITL 3 RESOLUTION.REF PROTEINS V. 39 271 2000REFN ISSN 0887-3585PMID 10813810DOI 10.1002/(SICI)1097-0134(20000601)39:43.3.CO;2-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4ig8 OAS1 structural basis for cytosolic double-stranded rna surveillance by human oas1 2.7Å AUTH J.DONOVAN,M.DUFNER,A.KORENNYKHTITL STRUCTURAL BASIS FOR CYTOSOLIC DOUBLE-STRANDED RNATITL 2 SURVEILLANCE BY HUMAN OLIGOADENYLATE SYNTHETASE 1.REF PROC.NATL.ACAD.SCI.USA V. 110 1652 2013REFN ISSN 0027-8424PMID 23319625DOI 10.1073/PNAS.1218528110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t2n HPN human hepsin protease in complex with the fab fragment of an inhibitory antibody 2.55Å AUTH T.KOSCHUBS,S.DENGL,H.DURR,K.KALUZA,G.GEORGES,C.HARTL,AUTH 2 S.JENNEWEIN,M.LANZENDORFER,J.AUER,A.STERN,K.S.HUANG,AUTH 3 K.PACKMAN,U.GUBLER,D.KOSTREWA,S.RIES,S.HANSEN,U.KOHNERT,AUTH 4 P.CRAMER,O.MUNDIGLTITL ALLOSTERIC ANTIBODY INHIBITION OF HUMAN HEPSIN PROTEASE.REF BIOCHEM.J. V. 442 483 2012REFN ISSN 0264-6021PMID 22132769DOI 10.1042/BJ20111317 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1psi SERPINA1 intact recombined alpha1-antitrypsin mutant phe 51 to leu 2.92Å AUTH P.R.ELLIOTT,D.A.LOMAS,R.W.CARRELL,J.P.ABRAHAMSTITL INHIBITORY CONFORMATION OF THE REACTIVE LOOP OFTITL 2 ALPHA 1-ANTITRYPSIN.REF NAT.STRUCT.BIOL. V. 3 676 1996REFN ISSN 1072-8368PMID 8756325DOI 10.1038/NSB0896-676 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2arq SERPINB2 human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with peptide n-acetyl-teaaagdggvmtgr-oh 1.85Å AUTH D.A.DI GIUSTO,A.P.SUTHERLAND,L.JANKOVA,S.J.HARROP,P.M.CURMI,AUTH 2 G.C.KINGTITL PLASMINOGEN ACTIVATOR INHIBITOR-2 IS HIGHLY TOLERANT TO P8TITL 2 RESIDUE SUBSTITUTION–IMPLICATIONS FOR SERPIN MECHANISTICTITL 3 MODEL AND PREDICTION OF NSSNP ACTIVITIESREF J.MOL.BIOL. V. 353 1069 2005REFN ISSN 0022-2836PMID 16214170DOI 10.1016/J.JMB.2005.09.008 Variant Set Distributions […]
General Structure Information 4bpb DDX58 structural insights into rna recognition by rig-i 2.58Å AUTH D.LUO,S.C.DING,A.VELA,A.KOHLWAY,B.D.LINDENBACH,A.M.PYLETITL STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY RIG-I.REF CELL(CAMBRIDGE,MASS.) V. 147 409 2011REFN ISSN 0092-8674PMID 22000018DOI 10.1016/J.CELL.2011.09.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants