Assessment of Structural Intolerance and Durability
General Structure Information 3dzx TBC1D22B crystal structure of the rabgap domain of human tbc1d22b 2.3Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,Y.SHEN,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF HUMAN TBC1D22BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ly5 DDX18 ddx18 dead-domain 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ray PRDM11 crystal structure of methyltransferase domain of human pr domain- containing protein 11 1.73Å AUTH A.DONG,H.ZENG,P.LOPPNAU,J.R.WALKER,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lxx GIMAP4 crystal structure of human gtpase imap family member 4 2.15Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.W.ANDREWS,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN GTPASE IMAP FAMILYTITL 2 MEMBER 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ijd PRDM9 crystal structure of methyltransferase domain of human pr domain- containing protein 9 2.15Å AUTH L.DOMBROVSKI,A.DONG,Y.LI,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,P.J.BROWN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ep0 PRDM12 methyltransferase domain of human pr domain-containing protein 12 2.1Å AUTH H.ZENG,M.F.AMAYA,P.LOPPNAU,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 12.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l08 UPF3A solution nmr structure of nonsense mrna reducing factor 3a from h. sapiens, northeast structural genomics consortium target hr4714b -1.0Å AUTH R.MANI,L.MAO,C.CICCOSANTI,R.SHASTRY,T.B.ACTON,R.XIAO,AUTH 2 G.V.T.SWAPNA,J.K.EVERETT,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF NONSENSE MRNA REDUCING FACTOR 3ATITL 2 FROM H. SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 3 TARGET HR4714BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 2ht9 GLRX2 the structure of dimeric human glutaredoxin 2 1.9Å AUTH C.JOHANSSON,K.L.KAVANAGH,O.GILEADI,U.OPPERMANNTITL REVERSIBLE SEQUESTRATION OF ACTIVE SITE CYSTEINES IN ATITL 2 2FE-2S-BRIDGED DIMER PROVIDES A MECHANISM FOR GLUTAREDOXIN 2TITL 3 REGULATION IN HUMAN MITOCHONDRIAREF J.BIOL.CHEM. V. 282 3077 2007REFN ISSN 0021-9258PMID 17121859DOI 10.1074/JBC.M608179200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]