Assessment of Structural Intolerance and Durability
General Structure Information 3qrf FOXP3 structure of a domain-swapped foxp3 dimer 2.8Å AUTH H.S.BANDUKWALA,Y.WU,M.FEUERER,Y.CHEN,B.BARBOZA,S.GHOSH,AUTH 2 J.C.STROUD,C.BENOIST,D.MATHIS,A.RAO,L.CHENTITL STRUCTURE OF A DOMAIN-SWAPPED FOXP3 DIMER ON DNA AND ITSTITL 2 FUNCTION IN REGULATORY T CELLS.REF IMMUNITY V. 34 479 2011REFN ISSN 1074-7613PMID 21458306DOI 10.1016/J.IMMUNI.2011.02.017 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4gl2 IFIH1 structural basis for dsrna duplex backbone recognition by mda5 3.56Å AUTH B.WU,A.PEISLEY,C.RICHARDS,H.YAO,X.ZENG,C.LIN,F.CHU,T.WALZ,AUTH 2 S.HURTITL STRUCTURAL BASIS FOR DSRNA RECOGNITION, FILAMENT FORMATION,TITL 2 AND ANTIVIRAL SIGNAL ACTIVATION BY MDA5.REF CELL(CAMBRIDGE,MASS.) V. 152 276 2013REFN ISSN 0092-8674PMID 23273991DOI 10.1016/J.CELL.2012.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3rqf PDCD10 cerebral cavernous malformation 3 (ccm3) in complex with paxillin ld2 2.7Å AUTH X.LI,W.JI,R.ZHANG,E.FOLTA-STOGNIEW,W.MIN,T.J.BOGGONTITL MOLECULAR RECOGNITION OF LEUCINE-ASPARTATE REPEAT (LD)TITL 2 MOTIFS BY THE FOCAL ADHESION TARGETING HOMOLOGY DOMAIN OFTITL 3 CEREBRAL CAVERNOUS MALFORMATION 3 (CCM3).REF J.BIOL.CHEM. V. 286 26138 2011REFN ISSN 0021-9258PMID 21632544DOI 10.1074/JBC.M110.211250 Variant Set Distributions Mapped Variants
General Structure Information 4h4f CTRC crystal structure of human chymotrypsin c (ctrc) bound to inhibitor eglin c from hirudo medicinalis 1.9Å AUTH J.BATRA,A.SZABO,T.R.CAULFIELD,A.S.SOARES,M.SAHIN-TOTH,AUTH 2 E.S.RADISKYTITL LONG-RANGE ELECTROSTATIC COMPLEMENTARITY GOVERNS SUBSTRATETITL 2 RECOGNITION BY HUMAN CHYMOTRYPSIN C, A KEY REGULATOR OFTITL 3 DIGESTIVE ENZYME ACTIVATION.REF J.BIOL.CHEM. V. 288 9848 2013REFN ISSN 0021-9258PMID 23430245DOI 10.1074/JBC.M113.457382 Variant Set […]
General Structure Information 1u7t HSD17B10 crystal structure of abad/hsd10 with a bound inhibitor 2.0Å AUTH C.R.KISSINGER,P.A.REJTO,L.A.PELLETIER,J.A.THOMSON,AUTH 2 R.E.SHOWALTER,M.A.ABREO,C.S.AGREE,S.MARGOSIAK,AUTH 3 J.J.MENG,R.M.AUST,D.VANDERPOOL,B.LI,AUTH 4 A.TEMPCZYK-RUSSELL,J.E.VILLAFRANCATITL CRYSTAL STRUCTURE OF HUMAN ABAD/HSD10 WITH A BOUNDTITL 2 INHIBITOR: IMPLICATIONS FOR DESIGN OF ALZHEIMERSTITL 3 DISEASE THERAPEUTICSREF J.MOL.BIOL. V. 342 943 2004REFN ISSN 0022-2836PMID 15342248DOI 10.1016/J.JMB.2004.07.071 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2ag5 BDH2 crystal structure of human dhrs6 1.84Å AUTH K.GUO,P.LUKACIK,E.PAPAGRIGORIOU,M.MEIER,W.H.LEE,J.ADAMSKI,AUTH 2 U.OPPERMANNTITL CHARACTERIZATION OF HUMAN DHRS6, AN ORPHAN SHORT CHAINTITL 2 DEHYDROGENASE/REDUCTASE ENZYME: A NOVEL, CYTOSOLIC TYPE 2TITL 3 R-BETA-HYDROXYBUTYRATE DEHYDROGENASEREF J.BIOL.CHEM. V. 281 10291 2006REFN ISSN 0021-9258PMID 16380372DOI 10.1074/JBC.M511346200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2efl FNBP1 crystal structure of the efc domain of formin-binding protein 17 2.61Å AUTH A.SHIMADA,H.NIWA,K.TSUJITA,S.SUETSUGU,K.NITTA,AUTH 2 K.HANAWA-SUETSUGU,R.AKASAKA,Y.NISHINO,M.TOYAMA,L.CHEN,AUTH 3 Z.-J.LIU,B.-C.WANG,M.YAMAMOTO,T.TERADA,A.MIYAZAWA,A.TANAKA,AUTH 4 S.SUGANO,M.SHIROUZU,K.NAGAYAMA,T.TAKENAWA,S.YOKOYAMATITL CURVED EFC/F-BAR-DOMAIN DIMERS ARE JOINED END TO END INTO ATITL 2 FILAMENT FOR MEMBRANE INVAGINATION IN ENDOCYTOSISREF CELL(CAMBRIDGE,MASS.) V. 129 761 2007REFN ISSN 0092-8674PMID 17512409DOI 10.1016/J.CELL.2007.03.040 Variant Set Distributions Ripley’s K […]
General Structure Information 1kcg ULBP3 nkg2d in complex with ulbp3 2.6Å AUTH S.RADAEV,B.ROSTRO,A.G.BROOKS,M.COLONNA,P.D.SUNTITL CONFORMATIONAL PLASTICITY REVEALED BY THETITL 2 COCRYSTAL STRUCTURE OF NKG2D AND ITS CLASS ITITL 3 MHC-LIKE LIGAND ULBP3.REF IMMUNITY V. 15 1039 2001REFN ISSN 1074-7613PMID 11754823DOI 10.1016/S1074-7613(01)00241-2 Variant Set Distributions Mapped Variants
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 2e30 CHP1 solution structure of the cytoplasmic region of na+/h+ exchanger 1 complexed with essential cofactor calcineurin b homologous protein 1 -1.0Å AUTH M.MISHIMA,S.WAKABAYASHI,C.KOJIMATITL SOLUTION STRUCTURE OF THE CYTOPLASMIC REGION OFTITL 2 NA+/H+ EXCHANGER 1 COMPLEXED WITH ESSENTIALTITL 3 COFACTOR CALCINEURIN B HOMOLOGOUS PROTEIN 1REF J.BIOL.CHEM. V. 282 2741 2007REFN ISSN 0021-9258PMID […]