General Structure Information 2zt7 GARS crystal structure of human glycyl-trna synthetase (glyrs) in complex with glycine and atp 2.7Å AUTH R.T.GUO,Y.E.CHONG,M.GUO,X.L.YANGTITL CRYSTAL STRUCTURES AND BIOCHEMICAL ANALYSES SUGGESTTITL 2 UNIQUE MECHANISM AND ROLE FOR HUMAN GLYRS IN AP4ATITL 3 HOMEOSTASISREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3evs GDF5 crystal structure of the gdf-5:bmp receptor ib complex. 2.1Å AUTH A.KOTZSCH,J.NICKEL,A.SEHER,W.SEBALD,T.D.MULLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS A SPRING-LOADED LATCH ASTITL 2 MOLECULAR MECHANISM FOR GDF-5-TYPE I RECEPTOR SPECIFICITY.REF EMBO J. V. 28 937 2009REFN ISSN 0261-4189PMID 19229295DOI 10.1038/EMBOJ.2009.37 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j1d TNNT2 crystal structure of the 46kda domain of human cardiac troponin in the ca2+ saturated form 2.61Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Mapped Variants
General Structure Information 2m74 FBN1 1h, 13c and 15n assignments of the four n-terminal domains of human fibrillin-1 -1.0Å AUTH D.A.YADIN,I.B.ROBERTSON,J.MCNAUGHT-DAVIS,P.EVANS,D.STODDART,AUTH 2 P.A.HANDFORD,S.A.JENSEN,C.REDFIELDTITL STRUCTURE OF THE FIBRILLIN-1 N-TERMINAL DOMAINS SUGGESTSTITL 2 THAT HEPARAN SULFATE REGULATES THE EARLY STAGES OFTITL 3 MICROFIBRIL ASSEMBLY.REF STRUCTURE V. 21 1743 2013REFN ISSN 0969-2126PMID 24035709DOI 10.1016/J.STR.2013.08.004 Variant Set Distributions Ripley’s […]
General Structure Information 1apj FBN1 nmr study of the transforming growth factor beta binding protein-like domain (tb module/8-cys domain), nmr, 21 structures -1.0Å AUTH X.YUAN,A.K.DOWNING,V.KNOTT,P.A.HANDFORDTITL SOLUTION STRUCTURE OF THE TRANSFORMING GROWTHTITL 2 FACTOR BETA-BINDING PROTEIN-LIKE MODULE, A DOMAINTITL 3 ASSOCIATED WITH MATRIX FIBRILS.REF EMBO J. V. 16 6659 1997REFN ISSN 0261-4189PMID 9362480DOI 10.1093/EMBOJ/16.22.6659 Variant Set […]
General Structure Information 2x7o TGFBR1 crystal structure of tgfbri complexed with an indolinone inhibitor 3.7Å AUTH G.J.ROTH,A.HECKEL,T.BRANDL,M.GRAUERT,S.HOERER,J.T.KLEY,AUTH 2 G.SCHNAPP,P.BAUM,D.MENNERICH,A.SCHNAPP,J.E.PARKTITL DESIGN, SYNTHESIS AND EVALUATION OF INDOLINONES ASTITL 2 INHIBITORS OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTORTITL 3 I (TGFBRI)REF J.MED.CHEM. V. 53 7287 2010REFN ISSN 0022-2623PMID 20919678DOI 10.1021/JM100812A Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1efv ETFB three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution 2.1Å AUTH D.L.ROBERTS,F.E.FRERMAN,J.J.KIMTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN ELECTRONTITL 2 TRANSFER FLAVOPROTEIN TO 2.1-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 93 14355 1996REFN ISSN 0027-8424PMID 8962055DOI 10.1073/PNAS.93.25.14355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fdj GALNS the molecular basis of mucopolysaccharidosis iv a, complex with galnac 2.81Å AUTH Y.RIVERA-COLON,E.K.SCHUTSKY,A.Z.KITA,S.C.GARMANTITL THE STRUCTURE OF HUMAN GALNS REVEALS THE MOLECULAR BASIS FORTITL 2 MUCOPOLYSACCHARIDOSIS IV A.REF J.MOL.BIOL. V. 423 736 2012REFN ISSN 0022-2836PMID 22940367DOI 10.1016/J.JMB.2012.08.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1hci ACTN2 crystal structure of the rod domain of alpha-actinin 2.8Å AUTH J.YLANNE,K.SCHEFFZEK,P.YOUNG,M.SARASTETITL CRYSTAL STRUCTURE OF THE ALPHA-ACTININ ROD REVEALSTITL 2 AN EXTENSIVE TORSIONAL TWISTREF STRUCTURE V. 9 597 2001REFN ISSN 0969-2126PMID 11470434DOI 10.1016/S0969-2126(01)00619-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2w86 FBN1 crystal structure of fibrillin-1 domains cbegf9hyb2cbegf10, calcium saturated form 1.8Å AUTH S.A.JENSEN,S.IQBAL,E.D.LOWE,C.REDFIELD,P.A.HANDFORDTITL STRUCTURE AND INTERDOMAIN INTERACTIONS OF A HYBRIDTITL 2 DOMAIN: A DISULPHIDE-RICH MODULE OF THETITL 3 FIBRILLIN/LTBP SUPERFAMILY OF MATRIX PROTEINS.REF STRUCTURE V. 17 759 2009REFN ISSN 0969-2126PMID 19446531DOI 10.1016/J.STR.2009.03.014 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants