Assessment of Structural Intolerance and Durability
General Structure Information 1lmj FBN1 nmr study of the fibrillin-1 cbegf12-13 pair of ca2+ binding epidermal growth factor-like domains -1.0Å AUTH R.S.SMALLRIDGE,P.WHITEMAN,J.M.WERNER,I.D.CAMPBELL,AUTH 2 P.A.HANDFORD,A.K.DOWNINGTITL SOLUTION STRUCTURE AND DYNAMICS OF A CALCIUMTITL 2 BINDING EPIDERMAL GROWTH FACTOR-LIKE DOMAIN PAIRTITL 3 FROM THE NEONATAL REGION OF HUMAN FIBRILLIN-1.REF J.BIOL.CHEM. V. 278 12199 2003REFN ISSN 0021-9258PMID 12511552DOI 10.1074/JBC.M208266200 […]
General Structure Information 2ew9 ATP7B solution structure of apowln5-6 -1.0Å AUTH D.ACHILA,L.BANCI,I.BERTINI,J.BUNCE,S.CIOFI-BAFFONI,AUTH 2 D.L.HUFFMANTITL STRUCTURE OF HUMAN WILSON PROTEIN DOMAINS 5 AND 6TITL 2 AND THEIR INTERPLAY WITH DOMAIN 4 AND THE COPPERTITL 3 CHAPERONE HAH1 IN COPPER UPTAKE.REF PROC.NATL.ACAD.SCI.USA V. 103 5729 2006REFN ISSN 0027-8424PMID 16571664DOI 10.1073/PNAS.0504472103 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1b98 NTF4 neurotrophin 4 (homodimer) 2.75Å AUTH R.C.ROBINSON,C.RADZIEJEWSKI,G.SPRAGGON,J.GREENWALD,AUTH 2 M.R.KOSTURA,L.D.BURTNICK,D.I.STUART,S.CHOE,AUTH 3 E.Y.JONESTITL THE STRUCTURES OF THE NEUROTROPHIN 4 HOMODIMER ANDTITL 2 THE BRAIN-DERIVED NEUROTROPHIC FACTOR/NEUROTROPHINTITL 3 4 HETERODIMER REVEAL A COMMON TRK-BINDING SITE.REF PROTEIN SCI. V. 8 2589 1999REFN ISSN 0961-8368PMID 10631974 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2jif ACADSB structure of human short-branched chain acyl-coa dehydrogenase (acadsb) 2.0Å AUTH A.C.W.PIKE,V.HOZJAN,C.SMEE,F.H.NIESEN,K.L.KAVANAGH,C.UMEANO,AUTH 2 A.P.TURNBULL,F.VON DELFT,J.WEIGELT,A.EDWARDS,C.H.ARROWSMITH,AUTH 3 M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN SHORT-BRANCHED CHAIN ACYL-COATITL 2 DEHYDROGENASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rbn MLH1 crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] 2.16Å AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3w82 IDUA human alpha-l-iduronidase in complex with iduronic acid 2.76Å AUTH N.MAITA,T.TSUKIMURA,T.TANIGUCHI,S.SAITO,K.OHNO,H.TANIGUCHI,AUTH 2 H.SAKURABATITL HUMAN ALPHA-L-IDURONIDASE USES ITS OWN N-GLYCAN AS ATITL 2 SUBSTRATE-BINDING AND CATALYTIC MODULEREF PROC.NATL.ACAD.SCI.USA V. 110 14628 2013REFN ISSN 0027-8424PMID 23959878DOI 10.1073/PNAS.1306939110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1uzp FBN1 integrin binding cbegf22-tb4-cbegf33 fragment of human fibrillin-1, sm bound form cbegf23 domain only. 1.78Å AUTH S.S.J.LEE,V.KNOTT,J.JOVANOVI,K.HARLOS,J.GRIMES,AUTH 2 L.CHOULIER,H.MARDON,D.I.STUART,P.A.HANDFORDTITL STRUCTURE OF THE INTEGRIN BINDING FRAGMENT FROMTITL 2 FIBRILLIN-1 GIVES NEW INSIGHTS INTO MICROFIBRILTITL 3 ORGANIZATIONREF STRUCTURE V. 12 717 2004REFN ISSN 0969-2126PMID 15062093DOI 10.1016/J.STR.2004.02.023 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 2cw6 HMGCL crystal structure of human hmg-coa lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria 2.1Å AUTH Z.FU,J.A.RUNQUIST,F.FOROUHAR,M.HUSSAIN,J.F.HUNT,AUTH 2 H.M.MIZIORKO,J.-J.P.KIMTITL CRYSTAL STRUCTURE OF HUMANTITL 2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE: INSIGHTSTITL 3 INTO CATALYSIS AND THE MOLECULAR BASIS FORTITL 4 HYDROXYMETHYLGLUTARIC ACIDURIAREF J.BIOL.CHEM. V. 281 7526 2006REFN ISSN 0021-9258PMID 16330550DOI 10.1074/JBC.M506880200 Variant […]
General Structure Information 1dc2 CDKN2A solution nmr structure of tumor suppressor p16ink4a, 20 structures -1.0Å AUTH C.YUAN,T.L.SELBY,J.LI,I.J.BYEON,M.D.TSAITITL TUMOR SUPPRESSOR INK4: REFINEMENT OF P16INK4ATITL 2 STRUCTURE AND DETERMINATION OF P15INK4B STRUCTURETITL 3 BY COMPARATIVE MODELING AND NMR DATA.REF PROTEIN SCI. V. 9 1120 2000REFN ISSN 0961-8368PMID 10892805 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1ej5 WAS solution structure of the autoinhibited conformation of wasp -1.0Å AUTH A.S.KIM,L.T.KAKALIS,N.ABDUL-MANAN,G.A.LIU,M.K.ROSENTITL AUTOINHIBITION AND ACTIVATION MECHANISMS OF THETITL 2 WISKOTT-ALDRICH SYNDROME PROTEIN.REF NATURE V. 404 151 2000REFN ISSN 0028-0836PMID 10724160DOI 10.1038/35010088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants