Assessment of Structural Intolerance and Durability
General Structure Information 2kdd CDCA8 solution structure of the conserved c-terminal dimerization domain of borealin -1.0Å AUTH E.BOURHIS,A.LINGEL,Q.PHUNG,W.J.FAIRBROTHER,AUTH 2 A.G.COCHRANTITL PHOSPHORYLATION OF A BOREALIN DIMERIZATION DOMAINTITL 2 IS REQUIRED FOR PROPER CHROMOSOME SEGREGATION.REF BIOCHEMISTRY V. 48 6783 2009REFN ISSN 0006-2960PMID 19530738DOI 10.1021/BI900530V Variant Set Distributions Mapped Variants
General Structure Information 3a6n HIST3H3 the nucleosome containing a testis-specific histone variant, human h3t 2.7Å AUTH H.TACHIWANA,W.KAGAWA,A.OSAKABE,K.KAWAGUCHI,T.SHIGA,AUTH 2 Y.HAYASHI-TAKANAKA,H.KIMURA,H.KURUMIZAKATITL STRUCTURAL BASIS OF INSTABILITY OF THE NUCLEOSOME CONTAININGTITL 2 A TESTIS-SPECIFIC HISTONE VARIANT, HUMAN H3TREF PROC.NATL.ACAD.SCI.USA V. 107 10454 2010REFN ISSN 0027-8424PMID 20498094DOI 10.1073/PNAS.1003064107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3cfv RBBP7 structural basis of the interaction of rbap46/rbap48 with histone h4 2.6Å AUTH N.V.MURZINA,X.Y.PEI,W.ZHANG,M.SPARKES,AUTH 2 J.VICENTE-GARCIA,J.V.PRATAP,S.H.MCLAUGHLIN,AUTH 3 T.R.BEN-SHAHAR,A.VERREAULT,B.F.LUISI,E.D.LAUETITL STRUCTURAL BASIS FOR THE RECOGNITION OF HISTONE H4TITL 2 BY THE HISTONE-CHAPERONE RBAP46.REF STRUCTURE V. 16 1077 2008REFN ISSN 0969-2126PMID 18571423DOI 10.1016/J.STR.2008.05.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 3dlm SETDB1 crystal structure of tudor domain of human histone-lysine n- methyltransferase setdb1 1.77Å AUTH L.DOMBROVSKI,M.F.AMAYA,P.LOPPNAU,A.BOCHKAREV,J.MIN,AUTH 2 H.WUTITL THE CRYSTAL STRUCTURE OF TUDOR DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uvl BIRC3 human bir3 domain of baculoviral inhibitor of apoptosis repeat-containing 3 (birc3) 1.91Å AUTH M.D.HERMAN,M.MOCHE,S.FLODIN,M.WELIN,L.TRESAUGUES,AUTH 2 I.JOHANSSON,M.NILSSON,P.NORDLUND,T.NYMANTITL STRUCTURES OF BIR DOMAINS FROM HUMAN NAIP AND CIAP2.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1091 2009REFN ISSN 1744-3091PMID 19923725DOI 10.1107/S1744309109038597 Variant Set Distributions Mapped Variants
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]
General Structure Information 2w5z KMT2A ternary complex of the mixed lineage leukaemia (mll1) set domain with the cofactor product s-adenosylhomocysteine and histone peptide. 2.2Å AUTH S.M.SOUTHALL,P.S.WONG,Z.ODHO,S.M.ROE,J.R.WILSONTITL STRUCTURAL BASIS FOR THE REQUIREMENT OF ADDITIONALTITL 2 FACTORS FOR MLL1 SET DOMAIN ACTIVITY ANDTITL 3 RECOGNITION OF EPIGENETIC MARKS.REF MOL.CELL V. 33 181 2009REFN ISSN 1097-2765PMID 19187761DOI 10.1016/J.MOLCEL.2008.12.029 […]