Assessment of Structural Intolerance and Durability
General Structure Information 3kn1 GOLPH3 crystal structure of golgi phosphoprotein 3 n-term truncation variant 2.9Å AUTH C.S.WOOD,K.R.SCHMITZ,N.J.BESSMAN,T.G.SETTY,AUTH 2 K.M.FERGUSON,C.G.BURDTITL PTDINS4P RECOGNITION BY VPS74/GOLPH3 LINKS PTDINSTITL 2 4-KINASE SIGNALING TO RETROGRADE GOLGI TRAFFICKING.REF J.CELL BIOL. V. 187 967 2009REFN ISSN 0021-9525PMID 20026658DOI 10.1083/JCB.200909063 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2y7b ANLN crystal structure of the ph domain of human actin-binding protein anillin anln 1.9Å AUTH M.VOLLMAR,J.WANG,T.KROJER,J.ELKINS,P.FILIPPAKOPOULOS,AUTH 2 E.UGOCHUKWU,R.COCKING,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE PH DOMAIN OF HUMAN ACTIN-BINDINGTITL 2 PROTEIN ANILLIN ANLNREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dba UNC45A the solution structure of the tetratrico peptide repeat of human smooth muscle cell associated protein-1, isoform 2 -1.0Å AUTH N.TOCHIO,A.SASAGAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE TETRATRICO PEPTIDETITL 2 REPEAT OF HUMAN SMOOTH MUSCLE CELL ASSOCIATEDTITL 3 PROTEIN-1, ISOFORM 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r3a SUV39H2 methyltransferase domain of human suppressor of variegation 3-9 homolog 2 2.0Å AUTH H.WU,J.MIN,V.V.LUNIN,T.ANTOSHENKO,L.DOMBROVSKI,AUTH 2 H.ZENG,A.ALLALI-HASSANI,V.CAMPAGNA-SLATER,M.VEDADI,AUTH 3 C.H.ARROWSMITH,A.N.PLOTNIKOV,M.SCHAPIRATITL STRUCTURAL BIOLOGY OF HUMAN H3K9 METHYLTRANSFERASESREF PLOS ONE V. 5 E8570 2010REFN ESSN 1932-6203PMID 20084102DOI 10.1371/JOURNAL.PONE.0008570 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3k6g TERF2IP crystal structure of rap1 and trf2 complex 1.95Å AUTH Y.CHEN,R.RAI,Z.R.ZHOU,J.KANOH,C.RIBEYRE,Y.YANG,H.ZHENG,AUTH 2 P.DAMAY,F.WANG,H.TSUJII,Y.HIRAOKA,D.SHORE,H.Y.HU,S.CHANG,AUTH 3 M.LEITITL A CONSERVED MOTIF WITHIN RAP1 HAS DIVERSIFIED ROLES INTITL 2 TELOMERE PROTECTION AND REGULATION IN DIFFERENT ORGANISMS.REF NAT.STRUCT.MOL.BIOL. V. 18 213 2011REFN ISSN 1545-9993PMID 21217703DOI 10.1038/NSMB.1974 Variant Set Distributions Mapped Variants
General Structure Information 3gix TXNL4B crystal structure of human splicing factor dim2 1.33Å AUTH T.C.JIN,F.GUO,Y.T.WANG,A.HOWARD,Y.Z.ZHANGTITL CRYSTAL STRUCTURE OF HUMAN SPLICING FACTOR DIM2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ve7 SPC25 crystal structure of a bonsai version of the human ndc80 complex 2.88Å AUTH C.CIFERRI,S.PASQUALATO,E.SCREPANTI,G.VARETTI,S.SANTAGUIDA,AUTH 2 G.DOS REIS,A.MAIOLICA,J.POLKA,J.G.DE LUCA,P.DE WULF,M.SALEK,AUTH 3 J.RAPPSILBER,C.A.MOORES,E.D.SALMON,A.MUSACCHIOTITL IMPLICATIONS FOR KINETOCHORE-MICROTUBULE ATTACHMENT FROMTITL 2 THE STRUCTURE OF AN ENGINEERED NDC80 COMPLEXREF CELL(CAMBRIDGE,MASS.) V. 133 427 2008REFN ISSN 0092-8674PMID 18455984DOI 10.1016/J.CELL.2008.03.020 Variant Set Distributions Mapped Variants