Assessment of Structural Intolerance and Durability
General Structure Information 4igg CTNNA1 full-length human alpha-catenin crystal structure 3.66Å AUTH E.S.RANGARAJAN,T.IZARDTITL DIMER ASYMMETRY DEFINES ALPHA-CATENIN INTERACTIONS.REF NAT.STRUCT.MOL.BIOL. V. 20 188 2013REFN ISSN 1545-9993PMID 23292143DOI 10.1038/NSMB.2479 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lmk GRM5 ligand binding domain of metabotropoc glutamate receptor mglur5 complexed with glutamate 2.44Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR5 COMPLEXED WITHTITL 2 GLUTAMATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p01 LRPAP1 the structure of receptor-associated protein(rap) -1.0Å AUTH D.LEE,J.D.WALSH,M.MIGLIORINI,P.YU,T.CAI,AUTH 2 C.D.SCHWIETERS,S.KRUEGER,D.K.STRICKLAND,Y.X.WANGTITL THE STRUCTURE OF RECEPTOR-ASSOCIATED PROTEIN (RAP).REF PROTEIN SCI. V. 16 1628 2007REFN ISSN 0961-8368PMID 17656581DOI 10.1110/PS.072865407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b5h BSG crystal structure of the extracellular portion of hab18g/cd147 2.8Å AUTH X.L.YU,T.HU,J.M.DU,J.P.DING,X.M.YANG,J.ZHANG,B.YANG,X.SHEN,AUTH 2 Z.ZHANG,W.D.ZHONG,N.WEN,H.JIANG,P.ZHU,Z.N.CHENTITL CRYSTAL STRUCTURE OF HAB18G/CD147: IMPLICATIONS FORTITL 2 IMMUNOGLOBULIN SUPERFAMILY HOMOPHILIC ADHESION.REF J.BIOL.CHEM. V. 283 18056 2008REFN ISSN 0021-9258PMID 18430721DOI 10.1074/JBC.M802694200 Variant Set Distributions Mapped Variants
General Structure Information 3qs9 FLT3 crystal structure of a human flt3 ligand-receptor ternary complex 7.8Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3e0g LIFR structure of the leukemia inhibitory factor receptor (lif-r) domains d1-d5 3.1Å AUTH G.SKINIOTIS,P.J.LUPARDUS,M.MARTICK,T.WALZ,K.C.GARCIATITL STRUCTURAL ORGANIZATION OF A FULL-LENGTH GP130/LIF-RTITL 2 CYTOKINE RECEPTOR TRANSMEMBRANE COMPLEX.REF MOL.CELL V. 31 737 2008REFN ISSN 1097-2765PMID 18775332DOI 10.1016/J.MOLCEL.2008.08.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1mx2 CDKN2C structure of f71n mutant of p18ink4c 2.25Å AUTH R.N.VENKATARAMANI,T.K.MACLACHLAN,X.CHAI,AUTH 2 W.S.EL-DEIRY,R.MARMORSTEINTITL STRUCTURE-BASED DESIGN OF P18INK4C PROTEINS WITHTITL 2 INCREASED THERMODYNAMIC STABILITY AND CELL CYCLETITL 3 INHIBITORY ACTIVITYREF J.BIOL.CHEM. V. 277 48827 2002REFN ISSN 0021-9258PMID 12370184DOI 10.1074/JBC.M208061200 Variant Set Distributions Mapped Variants
General Structure Information 2dks CEACAM8 solution structure of the first ig-like domain of human carcinoembryonic antigen related cell adhesion molecule 8 -1.0Å AUTH K.NAGASHIMA,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST IG-LIKE DOMAIN OFTITL 2 HUMAN CARCINOEMBRYONIC ANTIGEN RELATED CELLTITL 3 ADHESION MOLECULE 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wjx GRIA2 crystal structure of the human ionotropic glutamate receptor glur2 atd region at 4.1 a resolution 4.1Å AUTH A.CLAYTON,C.SIEBOLD,R.J.C.GILBERT,G.C.SUTTON,AUTH 2 K.HARLOS,R.A.J.MCILHINNEY,E.Y.JONES,A.R.ARICESCUTITL CRYSTAL STRUCTURE OF THE GLUR2 AMINO-TERMINALTITL 2 DOMAIN PROVIDES INSIGHTS INTO THE ARCHITECTURE ANDTITL 3 ASSEMBLY OF IONOTROPIC GLUTAMATE RECEPTORS.REF J.MOL.BIOL. V. 392 1125 2009REFN ISSN 0022-2836PMID 19651138DOI 10.1016/J.JMB.2009.07.082 Variant […]