Assessment of Structural Intolerance and Durability
General Structure Information 3rgh FLNA structure of filamin a immunoglobulin-like repeat 10 from homo sapiens 2.44Å AUTH R.C.PAGE,J.G.CLARK,S.MISRATITL STRUCTURE OF FILAMIN A IMMUNOGLOBULIN-LIKE REPEAT 10 FROMTITL 2 HOMO SAPIENS.REF ACTA CRYSTALLOGR.,SECT.F V. 67 871 2011REFN ESSN 1744-3091PMID 21821884DOI 10.1107/S1744309111024249 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2zw3 GJB2 structure of the connexin-26 gap junction channel at 3.5 angstrom resolution 3.5Å AUTH S.MAEDA,S.NAKAGAWA,M.SUGA,E.YAMASHITA,A.OSHIMA,AUTH 2 Y.FUJIYOSHI,T.TSUKIHARATITL STRUCTURE OF THE CONNEXIN 26 GAP JUNCTION CHANNELTITL 2 AT 3.5 A RESOLUTIONREF NATURE V. 458 597 2009REFN ISSN 0028-0836PMID 19340074DOI 10.1038/NATURE07869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2x8b ACHE crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-ii 2.95Å AUTH E.CARLETTI,J.P.COLLETIER,F.DUPEUX,M.TROVASLET,AUTH 2 P.MASSON,F.NACHONTITL STRUCTURAL EVIDENCE THAT HUMANTITL 2 ACETYLCHOLINESTERASE INHIBITED BY TABUN AGESTITL 3 THROUGH O-DEALKYLATIONREF J.MED.CHEM. V. 53 4002 2010REFN ISSN 0022-2623PMID 20408548DOI 10.1021/JM901853B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ksr CHRNB2 nmr structures of tm domain of the n-acetylcholine receptor b2 subunit -1.0Å AUTH V.BONDARENKO,T.TILLMAN,Y.XU,P.TANGTITL NMR STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THETITL 2 N-ACETYLCHOLINE RECEPTOR BETA2 SUBUNIT.REF BIOCHIM.BIOPHYS.ACTA V.1798 1608 2010REFN ISSN 0006-3002PMID 20441771DOI 10.1016/J.BBAMEM.2010.04.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3kfv TJP3 crystal structure of the sh3-kinase fragment of tight junction protein 3 (tjp3) in apo-form 2.8Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,N.ZHONG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE SH3-KINASE FRAGMENT OFTITL 2 TIGHT JUNCTION PROTEIN 3 (TJP3) IN APO-FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3iug ARHGAP32 crystal structure of the rhogap domain of rics 1.77Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,Y.LI,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF RICSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants