Assessment of Structural Intolerance and Durability
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1djl NNT the crystal structure of human transhydrogenase domain iii with bound nadp 2.0Å AUTH S.A.WHITE,S.J.PEAKE,S.MCSWEENEY,G.LEONARD,N.P.COTTON,AUTH 2 J.B.JACKSONTITL THE HIGH-RESOLUTION STRUCTURE OF THE NADP(H)-BINDINGTITL 2 COMPONENT (DIII) OF PROTON-TRANSLOCATING TRANSHYDROGENASETITL 3 FROM HUMAN HEART MITOCHONDRIA.REF STRUCTURE FOLD.DES. V. 8 1 2000REFN ISSN 0969-2126PMID 10673423DOI 10.1016/S0969-2126(00)00075-7 Variant Set Distributions Mapped Variants
General Structure Information 3qu6 IRF3 crystal structure of irf-3 dbd free form 2.3Å AUTH P.DE IOANNES,C.R.ESCALANTE,A.K.AGGARWALTITL STRUCTURES OF APO IRF-3 AND IRF-7 DNA BINDING DOMAINS:TITL 2 EFFECT OF LOOP L1 ON DNA BINDING.REF NUCLEIC ACIDS RES. V. 39 7300 2011REFN ISSN 0305-1048PMID 21596780DOI 10.1093/NAR/GKR325 Variant Set Distributions Mapped Variants
General Structure Information 3qu6 IRF3 crystal structure of irf-3 dbd free form 2.3Å AUTH P.DE IOANNES,C.R.ESCALANTE,A.K.AGGARWALTITL STRUCTURES OF APO IRF-3 AND IRF-7 DNA BINDING DOMAINS:TITL 2 EFFECT OF LOOP L1 ON DNA BINDING.REF NUCLEIC ACIDS RES. V. 39 7300 2011REFN ISSN 0305-1048PMID 21596780DOI 10.1093/NAR/GKR325 Variant Set Distributions Mapped Variants
General Structure Information 2axl WRN solution structure of a multifunctional dna- and protein- binding domain of human werner syndrome protein -1.0Å AUTH J.-S.HU,H.FENG,W.ZENG,G.-X.LIN,X.G.XITITL SOLUTION STRUCTURE OF A MULTIFUNCTIONAL DNA- ANDTITL 2 PROTEIN-BINDING MOTIF OF HUMAN WERNER SYNDROMETITL 3 PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 102 18379 2005REFN ISSN 0027-8424PMID 16339893DOI 10.1073/PNAS.0509380102 Variant Set Distributions Mapped Variants
General Structure Information 4ed5 ELAVL1 crystal structure of the two n-terminal rrm domains of hur complexed with rna 2.0Å AUTH H.WANG,F.ZENG,Q.LIU,H.LIU,Z.LIU,L.NIU,M.TENG,X.LITITL THE STRUCTURE OF THE ARE-BINDING DOMAINS OF HU ANTIGEN RTITL 2 (HUR) UNDERGOES CONFORMATIONAL CHANGES DURING RNA BINDING.REF ACTA CRYSTALLOGR.,SECT.D V. 69 373 2013REFN ISSN 0907-4449PMID 23519412DOI 10.1107/S0907444912047828 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3i35 LASP1 human sh3 domain of protein lasp1 1.4Å AUTH M.I.SIPONEN,A.K.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T KOTENYOVA,A.KOTZSCH,T.KRAGH NIELSEN,M.MOCHE,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN SH3 DOMAIN OF PROTEIN LASP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3aih OS9 human os-9 mrh domain complexed with alpha3,alpha6-man5 2.1Å AUTH T.SATOH,Y.CHEN,D.HU,S.HANASHIMA,K.YAMAMOTO,Y.YAMAGUCHITITL STRUCTURAL BASIS FOR OLIGOSACCHARIDE RECOGNITION OFTITL 2 MISFOLDED GLYCOPROTEINS BY OS-9 IN ER-ASSOCIATED DEGRADATIONREF MOL.CELL V. 40 905 2010REFN ISSN 1097-2765PMID 21172656DOI 10.1016/J.MOLCEL.2010.11.017 Variant Set Distributions Mapped Variants
General Structure Information 3n1p IHH crystal structure of ihhn bound to bocfn3 2.7Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants