Assessment of Structural Intolerance and Durability
General Structure Information 1kn0 RAD52 crystal structure of the human rad52 protein 2.85Å AUTH W.KAGAWA,H.KURUMIZAKA,R.ISHITANI,S.FUKAI,O.NUREKI,AUTH 2 T.SHIBATA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE HOMOLOGOUS-PAIRING DOMAINTITL 2 FROM THE HUMAN RAD52 RECOMBINASE IN THETITL 3 UNDECAMERIC FORM.REF MOL.CELL V. 10 359 2002REFN ISSN 1097-2765PMID 12191481DOI 10.1016/S1097-2765(02)00587-7 Variant Set Distributions Mapped Variants
General Structure Information 1c07 EPS15 structure of the third eps15 homology domain of human eps15 -1.0Å AUTH J.L.ENMON,T.DE BEER,M.OVERDUINTITL SOLUTION STRUCTURE OF EPS15S THIRD EH DOMAINTITL 2 REVEALS COINCIDENT PHE-TRP AND ASN-PRO-PHE BINDINGTITL 3 SITES.REF BIOCHEMISTRY V. 39 4309 2000REFN ISSN 0006-2960PMID 10757979DOI 10.1021/BI9927383 Variant Set Distributions Mapped Variants
General Structure Information 4fdj GALNS the molecular basis of mucopolysaccharidosis iv a, complex with galnac 2.81Å AUTH Y.RIVERA-COLON,E.K.SCHUTSKY,A.Z.KITA,S.C.GARMANTITL THE STRUCTURE OF HUMAN GALNS REVEALS THE MOLECULAR BASIS FORTITL 2 MUCOPOLYSACCHARIDOSIS IV A.REF J.MOL.BIOL. V. 423 736 2012REFN ISSN 0022-2836PMID 22940367DOI 10.1016/J.JMB.2012.08.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2×57 VIPR2 crystal structure of the extracellular domain of human vasoactive intestinal polypeptide receptor 2 2.1Å AUTH A.C.W.PIKE,A.J.BARR,A.QUIGLEY,N.BURGESS BROWN,A.DE RISO,AUTH 2 A.BULLOCK,G.BERRIDGE,J.R.C.MUNIZ,A.CHAIKAUD,M.VOLLMAR,AUTH 3 T.KROJER,E.UGOCHUKWU,F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,AUTH 4 J.WEIGELT,C.BOUNTRA,E.P.CARPENTERTITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMANTITL 2 VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4igg CTNNA1 full-length human alpha-catenin crystal structure 3.66Å AUTH E.S.RANGARAJAN,T.IZARDTITL DIMER ASYMMETRY DEFINES ALPHA-CATENIN INTERACTIONS.REF NAT.STRUCT.MOL.BIOL. V. 20 188 2013REFN ISSN 1545-9993PMID 23292143DOI 10.1038/NSMB.2479 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2kax S100A5 solution structure and dynamics of s100a5 in the apo and ca2+ -bound states -1.0Å AUTH I.BERTINI,S.DAS GUPTA,X.HU,T.KARAVELAS,C.LUCHINAT,AUTH 2 G.PARIGI,J.YUANTITL SOLUTION STRUCTURE AND DYNAMICS OF S100A5 IN THETITL 2 APO AND CA2+-BOUND STATESREF J.BIOL.INORG.CHEM. V. 14 1097 2009REFN ISSN 0949-8257PMID 19536568DOI 10.1007/S00775-009-0553-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3g81 SFTPD crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein d in complex with alpha methyl mannoside 1.8Å AUTH E.CROUCH,K.HARTSHORN,T.HORLACHER,B.MCDONALD,K.SMITH,AUTH 2 T.CAFARELLA,B.SEATON,P.H.SEEBERGER,J.HEADTITL RECOGNITION OF MANNOSYLATED LIGANDS AND INFLUENZA A VIRUS BYTITL 2 HUMAN SURFACTANT PROTEIN D: CONTRIBUTIONS OF AN EXTENDEDTITL 3 SITE AND RESIDUE 343.REF BIOCHEMISTRY […]
General Structure Information 2jc2 SRI the crystal structure of the natural f112l human sorcin mutant 2.5Å AUTH S.FRANCESCHINI,A.ILARI,D.VERZILI,C.ZAMPARELLI,AUTH 2 A.ANTARAMIAN,A.RUEDA,H.H.VALDIVIA,E.CHIANCONE,AUTH 3 G.COLOTTITITL MOLECULAR BASIS FOR THE IMPAIRED FUNCTION OF THETITL 2 NATURAL F112L SORCIN MUTANT: X-RAY CRYSTALTITL 3 STRUCTURE, CALCIUM AFFINITY, AND INTERACTION WITHTITL 4 ANNEXIN VII AND THE RYANODINE RECEPTOR.REF FASEB J. V. 22 […]
General Structure Information 3rbn MLH1 crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] 2.16Å AUTH L.DOMBROVSKY,A.DONG,A.WERNIMONT,P.LOPPNAU,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF MUTL PROTEIN HOMOLOG 1 ISOFORM 1 [HOMOTITL 2 SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3q8k FEN1 crystal structure of human flap endonuclease fen1 (wt) in complex with product 5-flap dna, sm3+, and k+ 2.2Å AUTH S.E.TSUTAKAWA,S.CLASSEN,B.R.CHAPADOS,A.S.ARVAI,L.D.FINGER,AUTH 2 G.GUENTHER,C.G.TOMLINSON,P.THOMPSON,A.H.SARKER,B.SHEN,AUTH 3 P.K.COOPER,J.A.GRASBY,J.A.TAINERTITL HUMAN FLAP ENDONUCLEASE STRUCTURES, DNA DOUBLE-BASETITL 2 FLIPPING, AND A UNIFIED UNDERSTANDING OF THE FEN1TITL 3 SUPERFAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 198 2011REFN ISSN 0092-8674PMID 21496641DOI 10.1016/J.CELL.2011.03.004 […]