Assessment of Structural Intolerance and Durability
General Structure Information 1j8e LRP1 crystal structure of ligand-binding repeat cr7 from lrp 1.85Å AUTH M.SIMONOVIC,K.DOLMER,W.HUANG,D.K.STRICKLAND,K.VOLZ,AUTH 2 P.G.GETTINSTITL CALCIUM COORDINATION AND PH DEPENDENCE OF THETITL 2 CALCIUM AFFINITY OF LIGAND-BINDING REPEAT CR7 FROMTITL 3 THE LRP. COMPARISON WITH RELATED DOMAINS FROM THETITL 4 LRP AND THE LDL RECEPTOR.REF BIOCHEMISTRY V. 40 15127 2001REFN ISSN 0006-2960PMID […]
General Structure Information 4k2p TIAM1 the structure of a quintuple mutant of the tiam1 ph-cc-ex domain 1.98Å AUTH M.JOSHI,L.GAKHAR,E.J.FUENTESTITL HIGH-RESOLUTION STRUCTURE OF THE TIAM1 PHN-CC-EX DOMAIN.REF ACTA CRYSTALLOGR.,SECT.F V. 69 744 2013REFN ESSN 1744-3091PMID 23832200DOI 10.1107/S1744309113014206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3vhx KIF23 the crystal structure of arf6-mklp1 (mitotic kinesin-like protein 1) complex 2.81Å AUTH H.MAKYIO,M.OHGI,T.TAKEI,S.TAKAHASHI,H.TAKATSU,Y.KATOH,AUTH 2 A.HANAI,T.UEDA,Y.KANAHO,Y.XIE,H.W.SHIN,H.KAMIKUBO,M.KATAOKA,AUTH 3 M.KAWASAKI,R.KATO,S.WAKATSUKI,K.NAKAYAMATITL STRUCTURAL BASIS FOR ARF6-MKLP1 COMPLEX FORMATION ON THETITL 2 FLEMMING BODY RESPONSIBLE FOR CYTOKINESISREF EMBO J. V. 31 2590 2012REFN ISSN 0261-4189PMID 22522702DOI 10.1038/EMBOJ.2012.89 Variant Set Distributions Mapped Variants
General Structure Information 2j2s KMT2A solution structure of the nonmethyl-cpg-binding cxxc domain of the leukaemia-associated mll histone methyltransferase -1.0Å AUTH M.D.ALLEN,C.G.GRUMMITT,C.HILCENKO,S.Y.MIN,AUTH 2 L.M.TONKIN,C.M.JOHNSON,S.M.FREUND,M.BYCROFT,AUTH 3 A.J.WARRENTITL SOLUTION STRUCTURE OF THE NONMETHYL-CPG-BINDINGTITL 2 CXXC DOMAIN OF THE LEUKAEMIA-ASSOCIATED MLLTITL 3 HISTONE METHYLTRANSFERASEREF EMBO J. V. 25 4503 2006REFN ISSN 0261-4189PMID 16990798DOI 10.1038/SJ.EMBOJ.7601340 Variant Set Distributions Mapped Variants
General Structure Information 1yse SATB1 solution structure of the mar-binding domain of satb1 -1.0Å AUTH H.YAMAGUCHI,M.TATENO,K.YAMASAKITITL SOLUTION STRUCTURE AND DNA-BINDING MODE OF THETITL 2 MATRIX ATTACHMENT REGION-BINDING DOMAIN OF THETITL 3 TRANSCRIPTION FACTOR SATB1 THAT REGULATES THETITL 4 T-CELL MATURATIONREF J.BIOL.CHEM. V. 281 5319 2006REFN ISSN 0021-9258PMID 16371359DOI 10.1074/JBC.M510933200 Variant Set Distributions Mapped Variants
General Structure Information 3uvj GUCY1A3 crystal structure of the catalytic domain of the heterodimeric human soluble guanylate cyclase 1. 2.08Å AUTH C.K.ALLERSTON,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLETITL 2 GUANYLATE CYCLASE.REF PLOS ONE V. 8 57644 2013REFN ESSN 1932-6203PMID 23505436DOI 10.1371/JOURNAL.PONE.0057644 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3qx3 TOP2B human topoisomerase iibeta in complex with dna and etoposide 2.16Å AUTH C.C.WU,T.K.LI,L.FARH,L.Y.LIN,T.S.LIN,Y.J.YU,T.J.YEN,AUTH 2 C.W.CHIANG,N.L.CHANTITL STRUCTURAL BASIS OF TYPE II TOPOISOMERASE INHIBITION BY THETITL 2 ANTICANCER DRUG ETOPOSIDEREF SCIENCE V. 333 459 2011REFN ISSN 0036-8075PMID 21778401DOI 10.1126/SCIENCE.1204117 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2c6y FOXK2 crystal structure of interleukin enhancer-binding factor 1 bound to dna 2.4Å AUTH K.-L.TSAI,C.-Y.HUANG,C.-H.CHANG,Y.-J.SUN,AUTH 2 W.-J.CHUANG,C.-D.HSIAOTITL CRYSTAL STRUCTURE OF THE HUMAN FOXK1A-DNA COMPLEXTITL 2 AND ITS IMPLICATIONS ON THE DIVERSE BINDINGTITL 3 SPECIFICITY OF WINGED HELIX/FORKHEAD PROTEINS.REF J.BIOL.CHEM. V. 281 17400 2006REFN ISSN 0021-9258PMID 16624804DOI 10.1074/JBC.M600478200 Variant Set Distributions Mapped Variants
General Structure Information 2enj PRKCQ solution sturcture of the c2 domain from human protein kinase c theta -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STURCTURE OF THE C2 DOMAIN FROM HUMANTITL 2 PROTEIN KINASE C THETAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ks9 GRM1 metabotropic glutamate receptor mglur1 complexed with ly341495 antagonist 1.9Å AUTH E.DOBROVETSKY,G.KHUTORESKAYA,A.SEITOVA,D.COSSAR,A.M.EDWARDS,AUTH 2 C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,A.BOCHKAREVTITL METABOTROPIC GLUTAMATE RECEPTOR MGLUR1 COMPLEXED WITHTITL 2 LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants