Assessment of Structural Intolerance and Durability
General Structure Information 2wax DDX6 structure of the human ddx6 c-terminal domain in complex with an edc3-fdf peptide 2.3Å AUTH F.TRITSCHLER,J.E.BRAUN,A.EULALIO,V.TRUFFAULT,AUTH 2 E.IZAURRALDE,O.WEICHENRIEDERTITL STRUCTURAL BASIS FOR THE MUTUALLY EXCLUSIVETITL 2 ANCHORING OF P BODY COMPONENTS EDC3 AND TRAL TOTITL 3 THE DEAD BOX PROTEIN DDX6/ME31B.REF MOL.CELL V. 33 661 2009REFN ISSN 1097-2765PMID 19285948DOI 10.1016/J.MOLCEL.2009.02.014 Variant […]
General Structure Information 3fe2 DDX5 human dead-box rna helicase ddx5 (p68), conserved domain i in complex with adp 2.6Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASESREF PLOS ONE V. 5 E1279 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 3dre CKB crystal structure of human brain-type creatine kinase 2.2Å AUTH S.M.BONG,J.H.MOON,K.H.NAM,K.S.LEE,Y.M.CHI,K.Y.HWANGTITL STRUCTURAL STUDIES OF HUMAN BRAIN-TYPE CREATINETITL 2 KINASE COMPLEXED WITH THE ADP-MG2+-NO3- -CREATINETITL 3 TRANSITION-STATE ANALOGUE COMPLEXREF FEBS LETT. V. 582 3959 2008REFN ISSN 0014-5793PMID 18977227DOI 10.1016/J.FEBSLET.2008.10.039 Variant Set Distributions Mapped Variants
General Structure Information 3gd7 CFTR crystal structure of human nbd2 complexed with n6- phenylethyl-atp (p-atp) 2.7Å AUTH S.ATWELL,S.ANTONYSAMY,W.B.GUGGINO,K.CONNERS,AUTH 2 S.EMTAGE,T.GHEYI,J.F.HUNT,H.A.LEWIS,F.LU,AUTH 3 J.M.SAUDER,P.C.WEBER,D.WETMORE,X.ZHAOTITL CRYSTAL STRUCTURE OF HUMAN NBD2 COMPLEXED WITHTITL 2 N6-PHENYLETHYL-ATP (P-ATP)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3iw4 PRKCA crystal structure of pkc alpha in complex with nvp-aeb071 2.8Å AUTH J.WAGNER,P.VON MATT,R.SEDRANI,R.ALBERT,N.COOKE,C.EHRHARDT,AUTH 2 M.GEISER,G.RUMMEL,W.STARK,A.STRAUSS,S.W.COWAN-JACOB,AUTH 3 C.BEERLI,G.WECKBECKER,J.P.EVENOU,G.ZENKE,S.COTTENSTITL DISCOVERY OFTITL 2 3-(1H-INDOL-3-YL)-4-[2-(4-METHYLPIPERAZIN-1-YL)QUINAZOLIN-4-TITL 3 YL]PYRROLE-2,5-DIONE (AEB071), A POTENT AND SELECTIVETITL 4 INHIBITOR OF PROTEIN KINASE C ISOTYPESREF J.MED.CHEM. V. 52 6193 2009REFN ISSN 0022-2623PMID 19827831DOI 10.1021/JM901108B Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3fe1 HSPA6 crystal structure of the human 70kda heat shock protein 6 (hsp70b) atpase domain in complex with adp and inorganic phosphate 2.2Å AUTH M.WISNIEWSKA,T.KARLBERG,L.LEHTIO,I.JOHANSSON,AUTH 2 T.KOTENYOVA,M.MOCHE,H.SCHUELERTITL CRYSTAL STRUCTURES OF THE ATPASE DOMAINS OF FOURTITL 2 HUMAN HSP70 ISOFORMS: HSPA1L/HSP70-HOM,TITL 3 HSPA2/HSP70-2, HSPA6/HSP70B, AND HSPA5/BIP/GRP78REF PLOS ONE V. 5 E8625 2010REFN ESSN […]
General Structure Information 1oe9 MYL6B crystal structure of myosin v motor with essential light chain – nucleotide-free 2.05Å AUTH P.-D.COUREUX,A.L.WELLS,J.MENETREY,C.M.YENGO,AUTH 2 C.A.MORRIS,H.L.SWEENEY,A.HOUDUSSETITL A STRUCTURAL STATE OF THE MYOSIN V MOTOR WITHOUTTITL 2 BOUND NUCLEOTIDEREF NATURE V. 425 419 2003REFN ISSN 0028-0836PMID 14508494DOI 10.1038/NATURE01927 Variant Set Distributions Mapped Variants
General Structure Information 3e3b CSNK2A2 crystal structure of catalytic subunit of human protein kinase ck2alpha prime with a potent indazole-derivative inhibitor 3.2Å AUTH T.NAKANIWA,T.KINOSHITA,Y.SEKIGUCHI,T.TADA,AUTH 2 I.NAKANISHI,K.KITAURA,Y.SUZUKI,H.OHNO,A.HIRASAWA,AUTH 3 G.TSUJIMOTOTITL STRUCTURE OF HUMAN PROTEIN KINASE CK2ALPHA2 WITH ATITL 2 POTENT INDAZOLE-DERIVATIVE INHIBITORREF ACTA CRYSTALLOGR.,SECT.F V. 65 75 2009REFN ESSN 1744-3091PMID 19193990DOI 10.1107/S1744309108043194 Variant Set Distributions Ripley’s K […]
General Structure Information 3g33 CDK4 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2cci CCNA2 crystal structure of phospho-cdk2 cyclin a in complex with a peptide containing both the substrate and recruitment sites of cdc6 2.7Å AUTH K.Y.CHENG,M.E.M.NOBLE,V.SKAMNAKI,N.R.BROWN,E.D.LOWE,AUTH 2 L.KONTOGIANNIS,K.SHEN,P.A.COLE,G.SILIGARDI,L.N.JOHNSONTITL THE ROLE OF THE PHOSPHO-CDK2/CYCLIN A RECRUITMENT SITE INTITL 2 SUBSTRATE RECOGNITIONREF J.BIOL.CHEM. V. 281 23167 2006REFN ISSN 0021-9258PMID 16707497DOI 10.1074/JBC.M600480200 Variant Set Distributions Mapped […]