Assessment of Structural Intolerance and Durability
General Structure Information 2v64 MAD2L1 crystallographic structure of the conformational dimer of the spindle assembly checkpoint protein mad2. 2.9Å AUTH M.MAPELLI,L.MASSIMILIANO,S.SANTAGUIDA,A.MUSACCHIOTITL THE MAD2 CONFORMATIONAL DIMER: STRUCTURE ANDTITL 2 IMPLICATIONS FOR THE SPINDLE ASSEMBLY CHECKPOINTREF CELL(CAMBRIDGE,MASS.) V. 131 730 2007REFN ISSN 0092-8674PMID 18022367DOI 10.1016/J.CELL.2007.08.049 Variant Set Distributions Mapped Variants
General Structure Information 2gf5 FADD structure of intact fadd (mort1) -1.0Å AUTH P.E.CARRINGTON,C.SANDU,Y.WEI,J.M.HILL,G.MORISAWA,AUTH 2 T.HUANG,E.GAVATHIOTIS,Y.WEI,M.H.WERNERTITL THE STRUCTURE OF FADD AND ITS MODE OF INTERACTIONTITL 2 WITH PROCASPASE-8REF MOL.CELL V. 22 599 2006REFN ISSN 1097-2765PMID 16762833DOI 10.1016/J.MOLCEL.2006.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3lqh KMT2A crystal structure of mll1 phd3-bromo in the free form 1.72Å AUTH Z.WANG,J.SONG,T.A.MILNE,G.G.WANG,H.LI,C.D.ALLIS,D.J.PATELTITL PRO ISOMERIZATION IN MLL1 PHD3-BROMO CASSETTE CONNECTSTITL 2 H3K4ME READOUT TO CYP33 AND HDAC-MEDIATED REPRESSION.REF CELL(CAMBRIDGE,MASS.) V. 141 1183 2010REFN ISSN 0092-8674PMID 20541251DOI 10.1016/J.CELL.2010.05.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3com STK4 crystal structure of mst1 kinase 2.2Å AUTH S.ATWELL,S.K.BURLEY,M.DICKEY,B.LEON,J.M.SAUDERTITL CRYSTAL STRUCTURE OF MST1 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 3wiy MCL1 crystal structure of mcl-1 in complex with compound 10 2.15Å AUTH Y.TANAKA,K.AIKAWA,G.NISHIDA,M.HOMMA,S.SOGABE,S.IGAKI,AUTH 2 Y.HAYANO,T.SAMESHIMA,I.MIYAHISA,T.KAWAMOTO,M.TAWADA,Y.IMAI,AUTH 3 M.INAZUKA,N.CHO,Y.IMAEDA,T.ISHIKAWATITL DISCOVERY OF POTENT MCL-1/BCL-XL DUAL INHIBITORS BY USING ATITL 2 HYBRIDIZATION STRATEGY BASED ON STRUCTURAL ANALYSIS OFTITL 3 TARGET PROTEINS.REF J.MED.CHEM. V. 56 9635 2013REFN ISSN 0022-2623PMID 24215352DOI 10.1021/JM401170C Variant Set Distributions Mapped Variants
General Structure Information 4bd7 BAX bax domain swapped dimer induced by octylmaltoside 2.9Å AUTH P.E.CZABOTAR,D.WESTPHAL,G.DEWSON,S.MA,C.HOCKINGS,AUTH 2 W.D.FAIRLIE,E.F.LEE,S.YAO,A.Y.ROBIN,B.J.SMITH,D.C.HUANG,AUTH 3 R.M.KLUCK,J.M.ADAMS,P.M.COLMANTITL BAX CRYSTAL STRUCTURES REVEAL HOW BH3 DOMAINS ACTIVATE BAXTITL 2 AND NUCLEATE ITS OLIGOMERIZATION TO INDUCE APOPTOSIS.REF CELL(CAMBRIDGE,MASS.) V. 152 519 2013REFN ISSN 0092-8674PMID 23374347DOI 10.1016/J.CELL.2012.12.031 Variant Set Distributions Mapped Variants