Assessment of Structural Intolerance and Durability
General Structure Information 3h6n PLXND1 crystal structure of the ubiquitin-like domain of plexin d1 2.0Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,M.BUCK,H.PARKTITL CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OFTITL 2 PLEXIN D1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vyt SCML2 the mbt repeats of human scml2 bind to peptides containing mono methylated lysine. 1.9Å AUTH C.M.SANTIVERI,B.C.LECHTENBERG,M.D.ALLEN,AUTH 2 A.SATHYAMURTHY,A.M.JAULENT,S.M.V.FREUND,M.BYCROFTTITL THE MALIGNANT BRAIN TUMOR REPEATS OF HUMAN SCML2TITL 2 BIND TO PEPTIDES CONTAINING MONOMETHYLATED LYSINE.REF J.MOL.BIOL. V. 382 1107 2008REFN ISSN 0022-2836PMID 18706910DOI 10.1016/J.JMB.2008.07.081 Variant Set Distributions Mapped Variants
General Structure Information 2z6e DAAM1 crystal structure of human daam1 fh2 2.8Å AUTH M.YAMASHITA,T.HIGASHI,S.SUETSUGU,Y.SATO,T.IKEDA,AUTH 2 R.SHIRAKAWA,T.KITA,T.TAKENAWA,H.HORIUCHI,S.FUKAI,AUTH 3 O.NUREKITITL CRYSTAL STRUCTURE OF HUMAN DAAM1 FORMIN HOMOLOGY 2TITL 2 DOMAINREF GENES CELLS V. 12 1255 2007REFN ISSN 1356-9597PMID 17986009DOI 10.1111/J.1365-2443.2007.01132.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2k9a ARL2BP the solution structure of the arl2 effector, bart -1.0Å AUTH L.K.BAILEY,L.J.CAMPBELL,K.A.EVETTS,K.LITTLEFIELD,AUTH 2 E.RAJENDRA,D.NIETLISPACH,D.OWEN,H.R.MOTTTITL THE STRUCTURE OF BINDER OF ARL2 (BART) REVEALS ATITL 2 NOVEL G PROTEIN BINDING DOMAIN: IMPLICATIONS FORTITL 3 FUNCTION.REF J.BIOL.CHEM. V. 284 992 2009REFN ISSN 0021-9258PMID 18981177DOI 10.1074/JBC.M806167200 Variant Set Distributions Mapped Variants
General Structure Information 2ice VSIG4 crig bound to c3c 3.1Å AUTH C.WIESMANN,K.J.KATSCHKE,J.YIN,K.Y.HELMY,M.STEFFEK,AUTH 2 W.J.FAIRBROTHER,S.A.MCCALLUM,L.EMBUSCADO,L.DEFORGE,P.E.HASS,AUTH 3 M.VAN LOOKEREN CAMPAGNETITL STRUCTURE OF C3B IN COMPLEX WITH CRIG GIVES INSIGHTS INTOTITL 2 REGULATION OF COMPLEMENT ACTIVATION.REF NATURE V. 444 217 2006REFN ISSN 0028-0836PMID 17051150DOI 10.1038/NATURE05263 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2vwf GAB2 grb2 sh3c (2) 1.58Å AUTH M.HARKIOLAKI,T.TSIRKA,M.LEWITZKY,P.C.SIMISTER,AUTH 2 D.JOSHI,L.E.BIRD,E.Y.JONES,N.OREILLY,S.M.FELLERTITL DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2TITL 2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2.REF STRUCTURE V. 17 809 2009REFN ISSN 0969-2126PMID 19523899DOI 10.1016/J.STR.2009.03.017 Variant Set Distributions Mapped Variants
General Structure Information 2jis CSAD human cysteine sulfinic acid decarboxylase (csad) in complex with plp. 1.6Å AUTH R.COLLINS,M.MOCHE,C.ARROWSMITH,H.BERGLUND,R.BUSAM,AUTH 2 L.G.DAHLGREN,A.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,B.M.HALLBERG,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTENYOVA,L.LEHTIO,AUTH 5 P.NORDLUND,T.NYMAN,D.OGG,C.PERSSON,J.SAGEMARK,AUTH 6 P.STENMARK,M.SUNDSTROM,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,AUTH 8 L.HOLMBERG-SCHIAVONETITL THE CRYSTAL STRUCTURE OF HUMAN CYSTEINE SULFINICTITL 2 ACID DECARBOXYLASE (CSAD)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3ex7 RBM8A the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Mapped Variants