Assessment of Structural Intolerance and Durability
General Structure Information 3bjc PDE5A crystal structure of the pde5a catalytic domain in complex with a novel inhibitor 2.0Å AUTH G.CHEN,H.WANG,H.ROBINSON,J.CAI,Y.WAN,H.KETITL AN INSIGHT INTO THE PHARMACOPHORES OFTITL 2 PHOSPHODIESTERASE-5 INHIBITORS FROM SYNTHETIC ANDTITL 3 CRYSTAL STRUCTURAL STUDIESREF BIOCHEM.PHARM. V. 75 1717 2008REFN ISSN 0006-2952PMID 18346713DOI 10.1016/J.BCP.2008.01.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3edi TLL1 crystal structure of tolloid-like protease 1 (tll-1) protease domain 1.4Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ecm PDE8A crystal structure of the unliganded pde8a catalytic domain 1.9Å AUTH H.WANG,Z.YAN,S.YANG,J.CAI,H.ROBINSON,H.KETITL KINETIC AND STRUCTURAL STUDIES OFTITL 2 PHOSPHODIESTERASE-8A AND IMPLICATION ON THETITL 3 INHIBITOR SELECTIVITYREF BIOCHEMISTRY V. 47 12760 2008REFN ISSN 0006-2960PMID 18983167DOI 10.1021/BI801487X Variant Set Distributions Mapped Variants
General Structure Information 2j60 FCN3 h-ficolin complexed to d-fucose 1.8Å AUTH V.GARLATTI,N.BELLOY,L.MARTIN,M.LACROIX,AUTH 2 M.MATSUSHITA,Y.ENDO,T.FUJITA,J.C.FONTECILLA-CAMPS,AUTH 3 G.J.ARLAUD,N.M.THIELENS,C.GABORIAUDTITL STRUCTURAL INSIGHTS INTO THE INNATE IMMUNETITL 2 RECOGNITION SPECIFICITIES OF L- AND H-FICOLINS.REF EMBO J. V. 26 623 2007REFN ISSN 0261-4189PMID 17215869DOI 10.1038/SJ.EMBOJ.7601500 Variant Set Distributions Mapped Variants
General Structure Information 2k1p ZRANB2 solution structure of the second zinc finger domain of zranb2/znf265 -1.0Å AUTH F.E.LOUGHLIN,R.E.MANSFIELD,P.M.VAZ,W.LEUNG,AUTH 2 S.SETIYAPUTRA,R.P.GRANT,E.S.CHEN,R.GAMSJAEGER,AUTH 3 J.P.MACKAYTITL THE ZINC FINGERS OF THE SR-PROEIN ZRANB2 RECOGNIZETITL 2 5SPLICE SITE-LIKE SEQUENCES AND CONSTITUTE ATITL 3 DISTINCT CLASS OF RNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dxc APBB1 crystal structure of the intracellular domain of human app in complex with fe65-ptb2 2.1Å AUTH J.RADZIMANOWSKI,B.SIMON,M.SATTLER,K.BEYREUTHER,AUTH 2 I.SINNING,K.WILDTITL STRUCTURE OF THE INTRACELLULAR DOMAIN OF THETITL 2 AMYLOID PRECURSOR PROTEIN IN COMPLEX WITHTITL 3 FE65-PTB2.REF EMBO REP. V. 9 1134 2008REFN ISSN 1469-221XPMID 18833287DOI 10.1038/EMBOR.2008.188 Variant Set Distributions Mapped Variants
General Structure Information 2k4p INPPL1 solution structure of ship2-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL NMR STUDIES OF A HETEROTYPIC SAM-SAM DOMAINTITL 2 ASSOCIATION: THE INTERACTION BETWEEN THE LIPIDTITL 3 PHOSPHATASE SHIP2 AND THE EPHA2 RECEPTOR.REF BIOCHEMISTRY V. 47 12721 2008REFN ISSN 0006-2960PMID 18991394DOI 10.1021/BI801713F Variant Set Distributions Mapped Variants
General Structure Information 2jju SIRPB1 structure of human signal regulatory protein (sirp) beta 1.19Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3hfh TCERG1 crystal structure of tandem ff domains 2.7Å AUTH M.LU,J.YANG,Z.REN,S.SABUI,A.ESPEJO,M.T.BEDFORD,AUTH 2 R.H.JACOBSON,D.JERUZALMI,J.S.MCMURRAY,X.CHENTITL CRYSTAL STRUCTURE OF THE THREE TANDEM FF DOMAINS OFTITL 2 THE TRANSCRIPTION ELONGATION REGULATOR CA150.REF J.MOL.BIOL. V. 393 397 2009REFN ISSN 0022-2836PMID 19660470DOI 10.1016/J.JMB.2009.07.086 Variant Set Distributions Mapped Variants
General Structure Information 2jun MID1 structure of the mid1 tandem b-boxes reveals an interaction reminiscent of intermolecular ring heterodimers -1.0Å AUTH H.TAO,B.N.SIMMONS,S.SINGIREDDY,M.JAKKIDI,K.M.SHORT,AUTH 2 T.C.COX,M.A.MASSIAHTITL STRUCTURE OF THE MID1 TANDEM B-BOXES REVEALS ANTITL 2 INTERACTION REMINISCENT OF INTERMOLECULAR RINGTITL 3 HETERODIMERSREF BIOCHEMISTRY V. 47 2450 2008REFN ISSN 0006-2960PMID 18220417DOI 10.1021/BI7018496 Variant Set Distributions Mapped Variants