3ECM.A | PDE8A

General Structure Information

PDB ID	3ecm
HGNC Gene Label(s)	PDE8A
Structure Name	crystal structure of the unliganded pde8a catalytic domain
Resolution	1.9Å
Reference	AUTH H.WANG,Z.YAN,S.YANG,J.CAI,H.ROBINSON,H.KETITL KINETIC AND STRUCTURAL STUDIES OFTITL 2 PHOSPHODIESTERASE-8A AND IMPLICATION ON THETITL 3 INHIBITOR SELECTIVITYREF BIOCHEMISTRY V. 47 12760 2008REFN ISSN 0006-2960PMID 18983167DOI 10.1021/BI801487X

Variant Set Distributions

ExAC Variants

Number Of Residues	338
Number Of SNVs	91
Number Of Permutations	40249
Optimal Distance Threshold	13.0
K Statistic	0.115
p-value	0.341

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
15:85659274	COSM1261787	R>W	A:487	(18.21, 39.74, 2.71)
15:85659278	rs201680379	I>T	A:488	(17.39, 36.02, 6.63)
15:85659284		R>Q	A:490	(15.02, 42.33, 7.27)
15:85659300		E>D	A:495	(5.76, 33.92, 9.51)
15:85659319		I>V	A:502	(9.03, 32.01, -0.48)
15:85659335		A>V	A:507	(17.55, 34.78, -1.92)
15:85659347		N>S	A:511	(19.11, 28.26, -2.30)
15:85660906		R>C	A:524	(4.95, 30.01, 15.33)
15:85660909		F>L	A:525	(3.84, 25.63, 16.14)
15:85660919		C>S	A:528	(11.93, 20.63, 20.81)
15:85660927		L>V	A:531	(10.06, 16.15, 20.45)
15:85660937		S>F	A:534	(18.25, 20.61, 21.04)
15:85660939	rs200743547	E>K	A:535	(18.24, 25.37, 18.66)
15:85660942		S>T	A:536	(21.47, 21.73, 18.15)
15:85660946		T>M	A:537	(19.25, 18.38, 17.45)
15:85660963		Q>E	A:543	(21.53, 21.16, 7.07)
15:85660970	rs139525378	I>T	A:545	(16.28, 17.23, 5.53)
15:85660979		N>S	A:548	(19.04, 15.31, 1.04)
15:85660988		S>C	A:551	(19.04, 22.69, -5.78)
15:85660994		N>S	A:553	(15.15, 20.02, -8.90)
15:85661006		N>S	A:557	(13.49, 22.96, -4.45)
15:85661011		T>A	A:559	(11.83, 26.52, -1.83)
15:85661020		A>T	A:562	(9.17, 25.86, 2.72)
15:85661023		D>N	A:563	(5.61, 26.88, 0.26)
15:85661026		V>M	A:564	(4.44, 23.07, 2.00)
15:85661050		L>I	A:572	(-1.91, 23.98, 11.95)
15:85661063		R>T	A:576	(-13.09, 23.97, 12.36)
15:85661069		K>T	A:578	(-6.40, 25.76, 17.19)
15:85664038		D>V	A:582	(-4.35, 16.82, 19.25)
15:85664049		E>K	A:586	(0.14, 20.67, 15.59)
15:85664055	rs561761878	A>T	A:588	(3.21, 15.50, 12.20)
15:85664064	rs530786771	I>L	A:591	(7.82, 16.73, 10.67)
15:85664065		I>T	A:591	(7.82, 16.73, 10.67)
15:85664067	COSM701515	A>T	A:592	(5.66, 16.15, 6.88)
15:85664070		A>P	A:593	(6.16, 19.15, 5.23)
15:85664107	rs370281755	N>S	A:605	(6.24, 7.79, -9.51)
15:85664131		S>I	A:613	(14.48, 2.91, -11.24)
15:85664158	rs144501404	T>I	A:622	(4.15, 0.96, -5.19)
15:85664173	rs146636539	S>N	A:627	(7.98, 5.51, 0.06)
15:85664176	rs140003003	H>R	A:628	(12.91, 7.68, -1.05)
15:85664182	rs374802816	A>V	A:630	(9.75, 8.62, 4.41)
15:85664189		L>F	A:632	(15.79, 9.16, 3.25)
15:85664191		A>V	A:633	(13.81, 10.75, 6.64)
15:85664198		Q>H	A:635	(17.22, 6.18, 6.55)
15:85664199		L>M	A:636	(18.74, 11.01, 7.23)
15:85664206	rs199542836	T>I	A:638	(17.41, 7.59, 13.27)
15:85664214	rs143606889	D>N	A:641	(22.86, 10.37, 17.84)
15:85666294		N>T	A:652	(4.54, 4.37, 23.14)
15:85666303	rs558540361	R>Q	A:655	(6.60, 3.47, 16.87)
15:85666311	rs199674218	R>C	A:658	(7.41, 6.08, 12.19)
15:85666323		I>F	A:662	(4.48, 7.47, 7.50)
15:85666326	rs140486977	D>N	A:663	(-0.56, 8.72, 6.73)
15:85666327	COSM4057539	D>A	A:663	(-0.56, 8.72, 6.73)
15:85666333		V>A	A:665	(4.25, 11.43, 3.31)
15:85666336		L>S	A:666	(2.18, 7.76, 1.87)
15:85666355		K>N	A:672	(-4.13, 7.39, -3.31)
15:85666362		E>K	A:675	(-9.07, 7.62, -1.96)
15:85666405		A>E	A:689	(-23.78, 19.83, 7.51)
15:85669438		E>Q	A:696	(-25.38, 27.90, 17.33)
15:85669442	rs376435048	T>I	A:697	(-26.82, 23.48, 20.65)
15:85669454		Q>R	A:701	(-21.11, 22.99, 20.18)
15:85669455		Q>H	A:701	(-21.11, 22.99, 20.18)
15:85669471	rs552839781	M>V	A:707	(-17.64, 13.85, 14.53)
15:85669475		L>P	A:708	(-14.62, 16.32, 13.93)
15:85669478		R>K	A:709	(-12.29, 16.29, 18.88)
15:85669492		R>W	A:714	(-7.31, 13.06, 14.88)
15:85669493	rs373904014	R>Q	A:714	(-7.31, 13.06, 14.88)
15:85669505		K>R	A:718	(-3.61, 14.68, 9.59)
15:85669510		M>L	A:720	(-7.41, 17.50, 2.93)
15:85669531		V>L	A:727	(-1.45, 21.63, -4.25)
15:85669538		N>S	A:729	(1.08, 26.89, -5.78)
15:85669541	rs141141657	P>L	A:730	(-2.96, 27.85, -7.20)
15:85669547		R>Q	A:732	(0.19, 31.12, -2.22)
15:85669557		Q>H	A:735	(3.87, 38.15, -8.13)
15:85669567		E>K	A:739	(7.97, 31.42, -10.38)
15:85669570		W>G	A:740	(5.79, 28.03, -6.92)
15:85669579		R>C	A:743	(10.24, 27.21, -10.09)
15:85669582		I>V	A:744	(6.17, 22.36, -12.30)
15:85669586		S>L	A:745	(6.56, 23.56, -16.26)
15:85669601	rs189984804	S>C	A:750	(12.90, 18.03, -18.62)
15:85679768	rs201797380	D>H	A:753	(12.91, 16.43, -23.44)
15:85679787	rs200642343	G>D	A:759	(12.31, 5.93, -25.53)
15:85679795		V>L	A:762	(5.45, 9.86, -23.23)
15:85679798		V>L	A:763	(3.81, 9.77, -19.12)
15:85679807		V>M	A:766	(0.39, 17.34, -22.69)
15:85679837		K>E	A:776	(-4.45, 26.42, -22.30)
15:85679838		K>R	A:776	(-4.45, 26.42, -22.30)
15:85679841		S>Y	A:777	(-2.18, 23.62, -18.36)
15:85679846		I>V	A:779	(-6.99, 26.62, -16.64)
15:85679853		F>S	A:781	(-3.90, 21.47, -11.78)
15:85679856	rs375929785	I>T	A:782	(-7.30, 24.91, -11.38)
15:85679885		A>T	A:792	(-13.85, 21.41, 0.89)
15:85681046		D>V	A:801	(-7.49, 35.08, 1.81)
15:85681067	rs532053506	N>I	A:808	(-7.01, 36.76, -9.51)
15:85681081		W>R	A:813	(-2.82, 31.46, -15.67)
15:85681087	rs150757036	G>R	A:815	(-6.35, 36.57, -20.00)