Assessment of Structural Intolerance and Durability
General Structure Information 2z6k RPA2 crystal structure of full-length human rpa14/32 heterodimer 3.0Å AUTH X.DENG,J.E.HABEL,V.KABALEESWARAN,E.H.SNELL,AUTH 2 M.S.WOLD,G.E.BORGSTAHLTITL STRUCTURE OF THE FULL-LENGTH HUMAN RPA14/32TITL 2 COMPLEX GIVES INSIGHTS INTO THE MECHANISM OF DNATITL 3 BINDING AND COMPLEX FORMATIONREF J.MOL.BIOL. V. 374 865 2007REFN ISSN 0022-2836PMID 17976647DOI 10.1016/J.JMB.2007.09.074 Variant Set Distributions Mapped Variants
General Structure Information 2c6f ACE structure of human somatic angiontensin-i converting enzyme n domain 3.01Å AUTH H.R.CORRADI,S.L.U.SCHWAGER,A.T.NCHINDA,AUTH 2 E.D.STURROCK,K.R.ACHARYATITL CRYSTAL STRUCTURE OF THE N DOMAIN OF HUMAN SOMATICTITL 2 ANGIOTENSIN I-CONVERTING ENZYME PROVIDES ATITL 3 STRUCTURAL BASIS FOR DOMAIN-SPECIFIC INHIBITORTITL 4 DESIGN.REF J.MOL.BIOL. V. 357 964 2006REFN ISSN 0022-2836PMID 16476442DOI 10.1016/J.JMB.2006.01.048 Variant Set Distributions Ripley’s […]
General Structure Information 3f7p ITGB4 crystal structure of a complex between integrin beta4 and plectin 2.75Å AUTH J.M.DE PEREDA,M.P.LILLO,A.SONNENBERGTITL STRUCTURAL BASIS OF THE INTERACTION BETWEENTITL 2 INTEGRIN ALPHA6BETA4 AND PLECTIN AT THETITL 3 HEMIDESMOSOMESREF EMBO J. V. 28 1180 2009REFN ISSN 0261-4189PMID 19242489DOI 10.1038/EMBOJ.2009.48 Variant Set Distributions Mapped Variants
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bu6 INSR crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide 1.95Å AUTH J.WU,Y.D.TSENG,C.F.XU,T.A.NEUBERT,M.F.WHITE,AUTH 2 S.R.HUBBARDTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 KRLB REGION IN INSULIN RECEPTOR SUBSTRATE-2.REF NAT.STRUCT.MOL.BIOL. V. 15 251 2008REFN ISSN 1545-9993PMID 18278056DOI 10.1038/NSMB.1388 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]
General Structure Information 2nll THRB retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna 1.9Å AUTH F.RASTINEJAD,T.PERLMANN,R.M.EVANS,P.B.SIGLERTITL STRUCTURAL DETERMINANTS OF NUCLEAR RECEPTORTITL 2 ASSEMBLY ON DNA DIRECT REPEATS.REF NATURE V. 375 203 1995REFN ISSN 0028-0836PMID 7746322DOI 10.1038/375203A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rol CD3E structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDINGREF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants
General Structure Information 2wns UMPS human orotate phosphoribosyltransferase (oprtase) domain of uridine 5-monophosphate synthase (umps) in complex with its substrate orotidine 5-monophosphate (omp) 1.9Å AUTH M.MOCHE,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTYENOVA,A.KOTZCH,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 5 J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,S.VANDENBERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,P.NORDLUNDTITL HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRTASE)TITL 2 DOMAIN OF URIDINE 5-MONOPHOSPHATE SYNTHASE (UMPS)TITL 3 IN COMPLEX WITH ITS SUBSTRATE […]
General Structure Information 3eq1 HMBS the crystal structure of human porphobilinogen deaminase at 2.8a resolution 2.8Å AUTH R.GILL,S.E.KOLSTOE,F.MOHAMMED,A.AL D-BASS,AUTH 2 J.E.MOSELY,M.SARWAR,J.B.COOPER,S.P.WOOD,AUTH 3 P.M.SHOOLINGIN-JORDANTITL STRUCTURE OF HUMAN PORPHOBILINOGEN DEAMINASE AT 2.8TITL 2 A: THE MOLECULAR BASIS OF ACUTE INTERMITTENTTITL 3 PORPHYRIAREF BIOCHEM.J. V. 420 17 2009REFN ISSN 0264-6021PMID 19207107DOI 10.1042/BJ20082077 Variant Set Distributions Ripley’s K Analysis […]