Assessment of Structural Intolerance and Durability
General Structure Information 2yux MYBPC1 solution structure of 3rd fibronectin type three domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF 3RD FIBRONECTIN TYPE THREETITL 2 DOMAIN OF SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants
General Structure Information 2om5 CNTN2 n-terminal fragment of human tax1 3.07Å AUTH M.MORTL,P.SONDEREGGER,K.DIEDERICHS,W.WELTETITL THE CRYSTAL STRUCTURE OF THE LIGAND-BINDING MODULE OF HUMANTITL 2 TAG-1 SUGGESTS A NEW MODE OF HOMOPHILIC INTERACTIONREF PROTEIN SCI. V. 16 2174 2007REFN ISSN 0961-8368PMID 17766378DOI 10.1110/PS.072802707 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3s97 CNTN1 ptprz cntn1 complex 2.3Å AUTH S.LAMPRIANOU,E.CHATZOPOULOU,J.L.THOMAS,S.BOUYAIN,S.HARROCHTITL A COMPLEX BETWEEN CONTACTIN-1 AND THE PROTEIN TYROSINETITL 2 PHOSPHATASE PTPRZ CONTROLS THE DEVELOPMENT OFTITL 3 OLIGODENDROCYTE PRECURSOR CELLS.REF PROC.NATL.ACAD.SCI.USA V. 108 17498 2011REFN ISSN 0027-8424PMID 21969550DOI 10.1073/PNAS.1108774108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rhf TYRO3 crystal structure of human tyro3-d1d2 1.96Å AUTH C.HEIRING,B.DAHLBACK,Y.A.MULLERTITL LIGAND RECOGNITION AND HOMOPHILIC INTERACTIONS IN TYRO3:TITL 2 STRUCTURAL INSIGHTS INTO THE AXL/TYRO3 RECEPTOR TYROSINETITL 3 KINASE FAMILY.REF J.BIOL.CHEM. V. 279 6952 2004REFN ISSN 0021-9258PMID 14623883DOI 10.1074/JBC.M311750200 Variant Set Distributions Mapped Variants
General Structure Information 2jjs CD47 structure of human cd47 in complex with human signal regulatory protein (sirp) alpha 1.85Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2h2b TJP1 crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttyl) 1.6Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,N.J.SKELTON,AUTH 2 S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZ DOMAIN ANDTITL 2 THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTS INTO DETERMINANTS OFTITL 3 PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant […]
General Structure Information 3tsz TJP1 crystal structure of pdz3-sh3-guk core module from human zo-1 in complex with 12mer peptide from human jam-a cytoplasmic tail 2.5Å AUTH J.NOMME,A.S.FANNING,M.CAFFREY,M.F.LYE,J.M.ANDERSON,A.LAVIETITL THE SRC HOMOLOGY 3 DOMAIN IS REQUIRED FOR JUNCTIONALTITL 2 ADHESION MOLECULE BINDING TO THE THIRD PDZ DOMAIN OF THETITL 3 SCAFFOLDING PROTEIN ZO-1.REF J.BIOL.CHEM. V. 286 43352 […]
General Structure Information 1o7b TNFAIP6 refined solution structure of the human tsg-6 link module -1.0Å AUTH C.D.BLUNDELL,D.MAHONEY,A.ALMOND,P.DEANGELIS,AUTH 2 J.D.KAHMANN,P.TERIETE,A.R.PICKFORD,I.D.CAMPBELL,AUTH 3 A.J.DAYTITL THE LINK MODULE FROM OVULATION- ANDTITL 2 INFLAMMATION-ASSOCIATED PROTEIN TSG-6 CHANGESTITL 3 CONFORMATION ON HYALURONAN BINDINGREF J.BIOL.CHEM. V. 278 49261 2003REFN ISSN 0021-9258PMID 12972412DOI 10.1074/JBC.M309623200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2npl CXADR nmr structure of card d2 domain -1.0Å AUTH S.JIANG,M.CAFFREYTITL SOLUTION STRUCTURE OF THE COXSACKIEVIRUS ANDTITL 2 ADENOVIRUS RECEPTOR DOMAIN 2REF PROTEIN SCI. V. 16 539 2007REFN ISSN 0961-8368PMID 17322536DOI 10.1110/PS.062643507 Variant Set Distributions Mapped Variants