Assessment of Structural Intolerance and Durability
General Structure Information 3rep ILK crystal structure of the ilk/alpha-parvin core complex (mnatp) 1.8Å AUTH K.FUKUDA,J.QINTITL CRYSTAL STRUCTURE OF THE ILK/ALPHA-PARVIN CORE COMPLEXTITL 2 (MNATP)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hcr MADCAM1 crystal structure of human madcam-1 d1d2 complexed with fab pf-547659 2.3Å AUTH T.SPRINGER,Y.YU,J.ZHU,J.-H.WANG,P.-S.HUANGTITL A DIFFERENT FOLD WITH AN INTEGRIN-BINDING LOOP SPECIALIZEDTITL 2 FOR FLEXIBILITY IN MUCOSAL ADDRESSIN CELL ADHESIONTITL 3 MOLECULE-1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2uvl BIRC3 human bir3 domain of baculoviral inhibitor of apoptosis repeat-containing 3 (birc3) 1.91Å AUTH M.D.HERMAN,M.MOCHE,S.FLODIN,M.WELIN,L.TRESAUGUES,AUTH 2 I.JOHANSSON,M.NILSSON,P.NORDLUND,T.NYMANTITL STRUCTURES OF BIR DOMAINS FROM HUMAN NAIP AND CIAP2.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1091 2009REFN ISSN 1744-3091PMID 19923725DOI 10.1107/S1744309109038597 Variant Set Distributions Mapped Variants
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1×61 TRIP6 solution structure of the first lim domain of thyroid receptor interacting protein 6 (trip6) -1.0Å AUTH X.R.QIN,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST LIM DOMAIN OFTITL 2 THYROID RECEPTOR INTERACTING PROTEIN 6 (TRIP6)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kzd TIAM1 crystal structure of free t-cell lymphoma invasion and metastasis-1 pdz domain 1.3Å AUTH T.R.SHEPHERD,S.M.KLAUS,X.LIU,S.RAMASWAMY,K.A.DEMALI,AUTH 2 E.J.FUENTESTITL THE TIAM1 PDZ DOMAIN COUPLES TO SYNDECAN1 AND PROMOTESTITL 2 CELL-MATRIX ADHESION.REF J.MOL.BIOL. V. 398 730 2010REFN ISSN 0022-2836PMID 20361982DOI 10.1016/J.JMB.2010.03.047 Variant Set Distributions Mapped Variants
General Structure Information 4ny0 PTK2 crystal structure of ferm domain of human focal adhesion kinase 2.8Å AUTH K.BRAMI-CHERRIER,N.GERVASI,D.ARSENIEVA,K.WALKIEWICZ,AUTH 2 M.C.BOUTTERIN,A.ORTEGA,P.G.LEONARD,B.SEANTIER,L.GASMI,AUTH 3 T.BOUCEBA,G.KADARE,J.A.GIRAULT,S.T.AROLDTITL FAK DIMERIZATION CONTROLS ITS KINASE-DEPENDENT FUNCTIONS ATTITL 2 FOCAL ADHESIONS.REF EMBO J. V. 33 356 2014REFN ISSN 0261-4189PMID 24480479DOI 10.1002/EMBJ.201386399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1avo PSME1 proteasome activator reg(alpha) 2.8Å AUTH J.R.KNOWLTON,S.C.JOHNSTON,F.G.WHITBY,C.REALINI,AUTH 2 Z.ZHANG,M.RECHSTEINER,C.P.HILLTITL STRUCTURE OF THE PROTEASOME ACTIVATOR REGALPHATITL 2 (PA28ALPHA).REF NATURE V. 390 639 1997REFN ISSN 0028-0836PMID 9403698DOI 10.1038/37670 Variant Set Distributions Mapped Variants
General Structure Information 2om5 CNTN2 n-terminal fragment of human tax1 3.07Å AUTH M.MORTL,P.SONDEREGGER,K.DIEDERICHS,W.WELTETITL THE CRYSTAL STRUCTURE OF THE LIGAND-BINDING MODULE OF HUMANTITL 2 TAG-1 SUGGESTS A NEW MODE OF HOMOPHILIC INTERACTIONREF PROTEIN SCI. V. 16 2174 2007REFN ISSN 0961-8368PMID 17766378DOI 10.1110/PS.072802707 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants