Assessment of Structural Intolerance and Durability
General Structure Information 4avm BIN2 crystal structure of the n-bar domain of human bridging integrator 2. 1.91Å AUTH C.K.ALLERSTON,T.KROJER,C.D.O.COOPER,M.VOLLMAR,AUTH 2 C.H.ARROWSMITH,A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADITITL CRYSTAL STRUCTURE OF THE N-BAR DOMAIN OF HUMAN BRIDGINGTITL 2 INTEGRATOR 2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ch9 KLHL3 crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide 1.84Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Mapped Variants
General Structure Information 2v8s VTI1B vti1b habc domain – epsinr enth domain complex 2.22Å AUTH S.E.MILLER,B.M.COLLINS,A.J.MCCOY,M.S.ROBINSON,AUTH 2 D.J.OWENTITL A SNARE-ADAPTOR INTERACTION IS A NEW MODE OF CARGOTITL 2 RECOGNITION IN CLATHRIN COATED VESICLESREF NATURE V. 450 570 2007REFN ISSN 0028-0836PMID 18033301DOI 10.1038/NATURE06353 Variant Set Distributions Mapped Variants
General Structure Information 1fb8 DAPP1 structure of the pleckstrin homology domain from dapp1/phish 2.4Å AUTH K.M.FERGUSON,J.M.KAVRAN,V.G.SANKARAN,E.FOURNIER,S.J.ISAKOFF,AUTH 2 E.Y.SKOLNIK,M.A.LEMMONTITL STRUCTURAL BASIS FOR DISCRIMINATION OF 3-PHOSPHOINOSITIDESTITL 2 BY PLECKSTRIN HOMOLOGY DOMAINS.REF MOL.CELL V. 6 373 2000REFN ISSN 1097-2765PMID 10983984DOI 10.1016/S1097-2765(00)00037-X Variant Set Distributions Mapped Variants
General Structure Information 1wr6 GGA3 crystal structure of gga3 gat domain in complex with ubiquitin 2.6Å AUTH M.KAWASAKI,T.SHIBA,Y.SHIBA,Y.YAMAGUCHI,N.MATSUGAKI,AUTH 2 N.IGARASHI,M.SUZUKI,R.KATO,K.KATO,K.NAKAYAMA,AUTH 3 S.WAKATSUKITITL MOLECULAR MECHANISM OF UBIQUITIN RECOGNITION BYTITL 2 GGA3 GAT DOMAIN.REF GENES CELLS V. 10 639 2005REFN ISSN 1356-9597PMID 15966896DOI 10.1111/J.1365-2443.2005.00865.X Variant Set Distributions Mapped Variants
General Structure Information 1ujk GGA1 vhs domain of human gga1 complexed with c-terminal phosphopeptide from bace 1.9Å AUTH T.SHIBA,S.KAMETAKA,M.KAWASAKI,M.SHIBATA,S.WAGURI,AUTH 2 Y.UCHIYAMA,S.WAKATSUKITITL INSIGHTS INTO THE PHOSPHOREGULATION OFTITL 2 BETA-SECRETASE SORTING SIGNAL BY THE VHS DOMAIN OFTITL 3 GGA1REF TRAFFIC V. 5 437 2004REFN ISSN 1398-9219PMID 15117318DOI 10.1111/J.1600-0854.2004.00188.X Variant Set Distributions Mapped Variants
General Structure Information 3vvw MAP1LC3C ndp52 in complex with lc3c 2.5Å AUTH N.V.MUHLINEN,M.AKUTSU,B.J.RAVENHILL,A.FOEGLEIN,S.BLOOR,AUTH 2 T.J.RUTHERFORD,S.M.FREUND,D.KOMANDER,F.RANDOWTITL LC3C, BOUND SELECTIVELY BY A NONCANONICAL LIR MOTIF INTITL 2 NDP52, IS REQUIRED FOR ANTIBACTERIAL AUTOPHAGYREF MOL.CELL V. 48 329 2012REFN ISSN 1097-2765PMID 23022382DOI 10.1016/J.MOLCEL.2012.08.024 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1h6e AP2M1 mu2 adaptin subunit (ap50) of ap2 adaptor (second domain), complexed with ctla-4 internalization peptide ttgvyvkmppt 3.6Å AUTH E.R.FOLLOWS,J.C.MCPHEAT,C.MINSHULL,N.C.MOORE,AUTH 2 R.A.PAUPTIT,S.ROWSELL,C.L.STACEY,J.J.STANWAY,AUTH 3 I.W.TAYLOR,W.M.ABBOTTTITL STUDY OF THE INTERACTION OF THE MEDIUM CHAIN MU2TITL 2 SUBUNIT OF THE CLATHRIN-ASSOCIATED ADAPTER PROTEINTITL 3 COMPLEX 2 WITH CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4TITL 4 AND CD28REF BIOCHEM.J. […]
General Structure Information 3gni STRADA structure of strad and mo25 2.35Å AUTH E.ZEQIRAJ,B.M.FILIPPI,S.GOLDIE,I.NAVRATILOVA,J.BOUDEAU,AUTH 2 M.DEAK,D.R.ALESSI,D.M.VAN AALTENTITL ATP AND MO25ALPHA REGULATE THE CONFORMATIONAL STATE OF THETITL 2 STRADALPHA PSEUDOKINASE AND ACTIVATION OF THE LKB1 TUMOURTITL 3 SUPPRESSORREF PLOS BIOL. V. 7 E1000 2009REFN ISSN 1544-9173PMID 19513107DOI 10.1371/JOURNAL.PBIO.1000126 Variant Set Distributions Mapped Variants
General Structure Information 4h8s APPL2 crystal structure of human appl2barph domain 3.5Å AUTH G.J.KING,J.STOCKLI,S.H.HU,B.WINNEN,W.G.DUPREZ,C.C.MEOLI,AUTH 2 J.R.JUNUTULA,R.J.JARROTT,D.E.JAMES,A.E.WHITTEN,J.L.MARTINTITL MEMBRANE CURVATURE PROTEIN EXHIBITS INTERDOMAIN FLEXIBILITYTITL 2 AND BINDS A SMALL GTPASE.REF J.BIOL.CHEM. V. 287 40996 2012REFN ISSN 0021-9258PMID 23055524DOI 10.1074/JBC.M112.349803 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants