Assessment of Structural Intolerance and Durability
General Structure Information 4jvh QKI structure of the star domain of quaking protein in complex with rna 3.5Å AUTH M.TEPLOVA,M.HAFNER,D.TEPLOV,K.ESSIG,T.TUSCHL,D.J.PATELTITL STRUCTURE-FUNCTION STUDIES OF STAR FAMILY QUAKING PROTEINSTITL 2 BOUND TO THEIR IN VIVO RNA TARGET SITES.REF GENES DEV. V. 27 928 2013REFN ISSN 0890-9369PMID 23630077DOI 10.1101/GAD.216531.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2mc3 MUS81 nmr solution structure of the winged-helix domain from mus81 structure-specific endonuclease -1.0Å AUTH A.J.FADDEN,S.SCHALBETTER,M.BOWLES,R.HARRIS,J.LALLY,A.M.CARR,AUTH 2 N.Q.MCDONALDTITL A WINGED HELIX DOMAIN IN HUMAN MUS81 BINDS DNA AND MODULATESTITL 2 THE ENDONUCLEASE ACTIVITY OF MUS81 COMPLEXES.REF NUCLEIC ACIDS RES. V. 41 9741 2013REFN ISSN 0305-1048PMID 23982516DOI 10.1093/NAR/GKT760 Variant Set Distributions Mapped Variants
General Structure Information 2e30 CHP1 solution structure of the cytoplasmic region of na+/h+ exchanger 1 complexed with essential cofactor calcineurin b homologous protein 1 -1.0Å AUTH M.MISHIMA,S.WAKABAYASHI,C.KOJIMATITL SOLUTION STRUCTURE OF THE CYTOPLASMIC REGION OFTITL 2 NA+/H+ EXCHANGER 1 COMPLEXED WITH ESSENTIALTITL 3 COFACTOR CALCINEURIN B HOMOLOGOUS PROTEIN 1REF J.BIOL.CHEM. V. 282 2741 2007REFN ISSN 0021-9258PMID […]
General Structure Information 1xb0 BIRC8 structure of the bir domain of iap-like protein 2 2.2Å AUTH H.SHIN,M.RENATUS,B.P.ECKELMAN,V.A.NUNES,AUTH 2 C.A.M.SAMPAIO,G.S.SALVESENTITL THE BIR DOMAIN OF IAP-LIKE PROTEIN 2 ISTITL 2 CONFORMATIONALLY UNSTABLE: IMPLICATIONS FORTITL 3 CASPASE INHIBITIONREF BIOCHEM.J. V. 385 1 2005REFN ISSN 0264-6021PMID 15485395DOI 10.1042/BJ20041107 Variant Set Distributions Mapped Variants
General Structure Information 2d8r THAP2 solution structure of the thap domain of the human thap domain-containing protein 2 -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THAP DOMAIN OF THE HUMANTITL 2 THAP DOMAIN-CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1xcr C11orf54 crystal structure of longer splice variant of ptd012 from homo sapiens reveals a novel zinc-containing fold 1.7Å AUTH B.A.MANJASETTY,K.BUESSOW,M.FIEBER-ERDMANN,Y.ROSKE,J.GOBOM,AUTH 2 C.SCHEICH,F.GOETZ,F.H.NIESEN,U.HEINEMANNTITL CRYSTAL STRUCTURE OF HOMO SAPIENS PTD012 REVEALS ATITL 2 ZINC-CONTAINING HYDROLASE FOLDREF PROTEIN SCI. V. 15 914 2006REFN ISSN 0961-8368PMID 16522806DOI 10.1110/PS.052037006 Variant Set Distributions Mapped Variants
General Structure Information 2r4h MAGI1 crystal structure of a c1190s mutant of the 6th pdz domain of human membrane associated guanylate kinase 2.05Å AUTH E.UGOCHUKWU,E.S.PILKA,V.HOZJAN,K.L.KAVANAGH,C.COOPER,AUTH 2 A.C.W.PIKE,J.M.ELKINS,D.A.DOYLE,F.VON DELFT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF A C1190S MUTANT OF THE 6TH PDZ DOMAINTITL 2 OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2a7o SETD2 solution structure of the hset2/hypb sri domain -1.0Å AUTH M.LI,H.P.PHATNANI,Z.GUAN,H.SAGE,A.GREENLEAF,P.ZHOUTITL SOLUTION STRUCTURE OF THE SET2 RPB1 INTERACTINGTITL 2 DOMAIN OF HUMAN SET2 AND ITS INTERACTION WITH THETITL 3 HYPERPHOSPHORYLATED C-TERMINAL DOMAIN OF RPB1REF PROC.NATL.ACAD.SCI.USA V. 102 17636 2005REFN ISSN 0027-8424PMID 16314571DOI 10.1073/PNAS.0506350102 Variant Set Distributions Mapped Variants
General Structure Information 2bmj AGAP2 gtpase like domain of centaurin gamma 1 (human) 2.1Å AUTH M.SOUNDARARAJAN,X.YANG,J.M.ELKINS,F.SOBOTT,D.A.DOYLETITL THE CENTAURIN GAMMA-1 GTPASE-LIKE DOMAIN FUNCTIONS AS ANTITL 2 NTPASE.REF BIOCHEM.J. V. 401 679 2007REFN ISSN 0264-6021PMID 17037982DOI 10.1042/BJ20060555 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kuq DLC1 crystal structure of the dlc1 rhogap domain 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,F.MACKENZIE,L.SHEN,AUTH 2 N.ZHONG,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,AUTH 3 J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE DLC1 RHOGAP DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants