Assessment of Structural Intolerance and Durability
General Structure Information 1g2t CCL26 solution structure of eotaxin-3 -1.0Å AUTH J.YE,K.L.MAYER,M.R.MAYER,M.J.STONETITL NMR SOLUTION STRUCTURE AND BACKBONE DYNAMICS OFTITL 2 THE CC CHEMOKINE EOTAXIN-3.REF BIOCHEMISTRY V. 40 7820 2001REFN ISSN 0006-2960PMID 11425309DOI 10.1021/BI010252S Variant Set Distributions Mapped Variants
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ygq WIF1 wif domain-epidermal growth factor (egf)-like domains 1-3 of human wnt inhibitory factor 1 in complex with 1,2-dipalmitoylphosphatidylcholine 3.95Å AUTH T.MALINAUSKAS,A.R.ARICESCU,W.LU,C.SIEBOLD,E.Y.JONESTITL MODULAR MECHANISM OF WNT SIGNALING INHIBITION BY WNTTITL 2 INHIBITORY FACTOR 1REF NAT.STRUCT.MOL.BIOL. V. 18 886 2011REFN ISSN 1545-9993PMID 21743455DOI 10.1038/NSMB.2081 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2ns2 SPIN1 crystal structure of spindlin1 2.2Å AUTH Q.ZHAO,L.QIN,F.JIANG,B.WU,W.YUE,F.XU,Z.RONG,H.YUAN,AUTH 2 X.XIE,Y.GAO,C.BAI,M.BARTLAM,X.PEI,Z.RAOTITL STRUCTURE OF HUMAN SPINDLIN1. TANDEM TUDOR-LIKETITL 2 DOMAINS FOR CELL CYCLE REGULATIONREF J.BIOL.CHEM. V. 282 647 2007REFN ISSN 0021-9258PMID 17082182DOI 10.1074/JBC.M604029200 Variant Set Distributions Mapped Variants
General Structure Information 1wyo MAPRE3 solution structure of the ch domain of human microtubule- associated protein rp/eb family member 3 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN OF HUMANTITL 2 MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBERTITL 3 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kum CCL27 solution structure of the human chemokine ccl27 -1.0Å AUTH A.L.JANSMA,J.P.KIRKPATRICK,A.R.HSU,T.M.HANDEL,D.NIETLISPACHTITL NMR ANALYSIS OF THE STRUCTURE, DYNAMICS, AND UNIQUETITL 2 OLIGOMERIZATION PROPERTIES OF THE CHEMOKINE CCL27.REF J.BIOL.CHEM. V. 285 14424 2010REFN ISSN 0021-9258PMID 20200157DOI 10.1074/JBC.M109.091108 Variant Set Distributions Mapped Variants
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3qe9 EXO1 crystal structure of human exonuclease 1 exo1 (d173a) in complex with dna (complex i) 2.51Å AUTH J.ORANS,E.A.MCSWEENEY,R.R.IYER,M.A.HAST,H.W.HELLINGA,AUTH 2 P.MODRICH,L.S.BEESETITL STRUCTURES OF HUMAN EXONUCLEASE 1 DNA COMPLEXES SUGGEST ATITL 2 UNIFIED MECHANISM FOR NUCLEASE FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 212 2011REFN ISSN 0092-8674PMID 21496642DOI 10.1016/J.CELL.2011.03.005 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4i5l PPP2R3B structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation 2.43Å AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 Variant Set Distributions Mapped Variants
General Structure Information 2ouc DUSP10 crystal structure of the map kinase binding domain of mkp5 2.2Å AUTH X.TAO,L.TONGTITL CRYSTAL STRUCTURE OF THE MAP KINASE BINDING DOMAINTITL 2 AND THE CATALYTIC DOMAIN OF HUMAN MKP5.REF PROTEIN SCI. V. 16 880 2007REFN ISSN 0961-8368PMID 17400920DOI 10.1110/PS.062712807 Variant Set Distributions Mapped Variants