Assessment of Structural Intolerance and Durability
General Structure Information 2npp PPP2R1A structure of the protein phosphatase 2a holoenzyme 3.3Å AUTH Y.XU,Y.XING,Y.CHEN,Y.CHAO,Z.LIN,E.FAN,J.W.YU,S.STRACK,AUTH 2 P.D.JEFFREY,Y.SHITITL STRUCTURE OF THE PROTEIN PHOSPHATASE 2A HOLOENZYMEREF CELL(CAMBRIDGE,MASS.) V. 127 1239 2006REFN ISSN 0092-8674PMID 17174897DOI 10.1016/J.CELL.2006.11.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2llt S100A1 post-translational s-nitrosylation is an endogenous factor fine-tuning human s100a1 protein properties -1.0Å AUTH M.LENARCIC ZIVKOVIC,M.ZAREBA-KOZIOL,L.ZHUKOVA,J.POZNANSKI,AUTH 2 I.ZHUKOV,A.WYSLOUCH-CIESZYNSKATITL POST-TRANSLATIONAL S-NITROSYLATION IS AN ENDOGENOUS FACTORTITL 2 FINE TUNING THE PROPERTIES OF HUMAN S100A1 PROTEIN.REF J.BIOL.CHEM. V. 287 40457 2012REFN ISSN 0021-9258PMID 22989881DOI 10.1074/JBC.M112.418392 Variant Set Distributions Mapped Variants
General Structure Information 1m9k NOS3 human endothelial nitric oxide synthase with 7- nitroindazole bound 2.01Å AUTH R.J.ROSENFELD,E.D.GARCIN,K.PANDA,G.ANDERSSON,AUTH 2 A.ABERG,A.V.WALLACE,G.M.MORRIS,A.J.OLSON,AUTH 3 D.J.STUEHR,J.A.TAINER,E.D.GETZOFFTITL CONFORMATIONAL CHANGES IN NITRIC OXIDE SYNTHASESTITL 2 INDUCED BY CHLORZOXAZONE AND NITROINDAZOLES:TITL 3 CRYSTALLOGRAPHIC AND COMPUTATIONAL ANALYSES OFTITL 4 INHIBITOR POTENCYREF BIOCHEMISTRY V. 41 13915 2002REFN ISSN 0006-2960PMID 12437348DOI 10.1021/BI026313J Variant Set Distributions Ripley’s […]
General Structure Information 3v4p ITGB7 crystal structure of a4b7 headpiece complexed with fab act-1 3.15Å AUTH Y.YU,J.ZHU,L.Z.MI,T.WALZ,H.SUN,J.CHEN,T.A.SPRINGERTITL STRUCTURAL SPECIALIZATIONS OF A4B7, AN INTEGRIN THATTITL 2 MEDIATES ROLLING ADHESIONREF J.CELL BIOL. V. 196 131 2012REFN ISSN 0021-9525PMID 22232704DOI 10.1083/JCB.201110023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2m0g U2AF2 structure, phosphorylation and u2af65 binding of the nterminal domain of splicing factor 1 during 3 splice site recognition -1.0Å AUTH Y.ZHANG,T.MADL,I.BAGDIUL,T.KERN,H.S.KANG,P.ZOU,N.MAUSBACHER,AUTH 2 S.A.SIEBER,A.KRAMER,M.SATTLERTITL STRUCTURE, PHOSPHORYLATION AND U2AF65 BINDING OF THETITL 2 N-TERMINAL DOMAIN OF SPLICING FACTOR 1 DURING 3-SPLICE SITETITL 3 RECOGNITION.REF NUCLEIC ACIDS RES. V. 41 1343 2013REFN ISSN […]
General Structure Information 1apy AGA human aspartylglucosaminidase 2.0Å AUTH C.OINONEN,R.TIKKANEN,J.ROUVINEN,L.PELTONENTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMALTITL 2 ASPARTYLGLUCOSAMINIDASE.REF NAT.STRUCT.BIOL. V. 2 1102 1995REFN ISSN 1072-8368PMID 8846222DOI 10.1038/NSB1295-1102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1apy AGA human aspartylglucosaminidase 2.0Å AUTH C.OINONEN,R.TIKKANEN,J.ROUVINEN,L.PELTONENTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMALTITL 2 ASPARTYLGLUCOSAMINIDASE.REF NAT.STRUCT.BIOL. V. 2 1102 1995REFN ISSN 1072-8368PMID 8846222DOI 10.1038/NSB1295-1102 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ivh IVD structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity 2.6Å AUTH K.A.TIFFANY,D.L.ROBERTS,M.WANG,R.PASCHKE,AUTH 2 A.W.MOHSEN,J.VOCKLEY,J.J.KIMTITL STRUCTURE OF HUMAN ISOVALERYL-COA DEHYDROGENASE ATTITL 2 2.6 A RESOLUTION: STRUCTURAL BASIS FOR SUBSTRATETITL 3 SPECIFICITY,.REF BIOCHEMISTRY V. 36 8455 1997REFN ISSN 0006-2960PMID 9214289DOI 10.1021/BI970422U Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2k3t FLNA solution structure of ig-like domain 23 from human filamin a -1.0Å AUTH F.NAKAMURA,O.HEIKKINEN,O.T.PENTIKAINEN,T.M.OSBORN,AUTH 2 K.E.KASZA,D.A.WEITZ,O.KUPIAINEN,P.PERMI,AUTH 3 I.KILPELAINEN,J.YLANNE,J.H.HARTWIG,T.P.STOSSELTITL MOLECULAR BASIS OF FILAMIN A-FILGAP INTERACTIONTITL 2 AND ITS IMPAIRMENT IN CONGENITAL DISORDERSTITL 3 ASSOCIATED WITH FILAMIN A MUTATIONSREF PLOS ONE V. 4 E4928 2009REFN ESSN 1932-6203PMID 19293932DOI 10.1371/JOURNAL.PONE.0004928 Variant Set Distributions Mapped […]
General Structure Information 1rn7 CST5 structure of human cystatin d 2.5Å AUTH M.ALVAREZ-FERNANDEZ,Y.H.LIANG,M.ABRAHAMSON,X.D.SUTITL CRYSTAL STRUCTURE OF HUMAN CYSTATIN D, A CYSTEINETITL 2 PEPTIDASE INHIBITOR WITH RESTRICTED INHIBITIONTITL 3 PROFILE.REF J.BIOL.CHEM. V. 280 18221 2005REFN ISSN 0021-9258PMID 15728581DOI 10.1074/JBC.M411914200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants