General Structure Information
| PDB ID | 1m9k |
| HGNC Gene Label(s) | NOS3 |
| Structure Name | human endothelial nitric oxide synthase with 7- nitroindazole bound |
| Resolution | 2.01Å |
| Reference | AUTH R.J.ROSENFELD,E.D.GARCIN,K.PANDA,G.ANDERSSON,AUTH 2 A.ABERG,A.V.WALLACE,G.M.MORRIS,A.J.OLSON,AUTH 3 D.J.STUEHR,J.A.TAINER,E.D.GETZOFFTITL CONFORMATIONAL CHANGES IN NITRIC OXIDE SYNTHASESTITL 2 INDUCED BY CHLORZOXAZONE AND NITROINDAZOLES:TITL 3 CRYSTALLOGRAPHIC AND COMPUTATIONAL ANALYSES OFTITL 4 INHIBITOR POTENCYREF BIOCHEMISTRY V. 41 13915 2002REFN ISSN 0006-2960PMID 12437348DOI 10.1021/BI026313J |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 401 |
| Number Of SNVs | 109 |
| Number Of Permutations | 22255 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.038 |
| p-value | 0.297 |
COSMIC
| Number Of Residues | 401 |
| Number Of SNVs | 8 |
| Number Of Permutations | 5216 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.107 |
| p-value | 0.384 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 109 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.132 |
| p-value | 0.859 |