Assessment of Structural Intolerance and Durability
General Structure Information 3bwy COMT crystal structure of human 108m catechol o- methyltransferase bound with s-adenosylmethionine and inhibitor dinitrocatechol 1.3Å AUTH K.RUTHERFORD,I.LE TRONG,R.E.STENKAMP,W.W.PARSONTITL CRYSTAL STRUCTURES OF HUMAN 108V AND 108M CATECHOLTITL 2 O-METHYLTRANSFERASE.REF J.MOL.BIOL. V. 380 120 2008REFN ISSN 0022-2836PMID 18486144DOI 10.1016/J.JMB.2008.04.040 Variant Set Distributions Mapped Variants
General Structure Information 2hev TNFSF4 crystal structure of the complex between ox40l and ox40 2.41Å AUTH D.M.COMPAAN,S.G.HYMOWITZTITL THE CRYSTAL STRUCTURE OF THE COSTIMULATORY OX40-OX40LTITL 2 COMPLEX.REF STRUCTURE V. 14 1321 2006REFN ISSN 0969-2126PMID 16905106DOI 10.1016/J.STR.2006.06.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bbb NME2 crystal structure of the nm23-h2 transcription factor complex with dinucleotide d(ag) 1.3Å AUTH T.S.DEXHEIMER,S.S.CAREY,S.ZUOHE,V.M.GOKHALE,X.HU,L.B.MURATA,AUTH 2 E.M.MAES,A.WEICHSEL,D.SUN,E.J.MEUILLET,W.R.MONTFORT,AUTH 3 L.H.HURLEYTITL NM23-H2 MAY PLAY AN INDIRECT ROLE IN TRANSCRIPTIONALTITL 2 ACTIVATION OF C-MYC GENE EXPRESSION BUT DOES NOT CLEAVE THETITL 3 NUCLEASE HYPERSENSITIVE ELEMENT III1.REF MOL.CANCER THER. V. 8 1363 2009REFN ISSN 1535-7163PMID […]
General Structure Information 4k33 FGFR3 crystal strucure of fgf receptor 3 (fgfr3) kinase domain harboring the k650e mutation, a gain-of-function mutation responsible for thanatophoric dysplasia type ii and spermatocytic seminoma 2.34Å AUTH Z.HUANG,H.CHEN,S.BLAIS,T.A.NEUBERT,X.LI,M.MOHAMMADITITL STRUCTURAL MIMICRY OF A-LOOP TYROSINE PHOSPHORYLATION BY ATITL 2 PATHOGENIC FGF RECEPTOR 3 MUTATION.REF STRUCTURE V. 21 1889 2013REFN ISSN 0969-2126PMID 23972473DOI […]
General Structure Information 3kq4 GIF structure of intrinsic factor-cobalamin bound to its receptor cubilin 3.3Å AUTH C.B.ANDERSEN,M.MADSEN,T.STORM,S.K.MOESTRUP,G.R.ANDERSENTITL STRUCTURAL BASIS FOR RECEPTOR RECOGNITION OFTITL 2 VITAMIN-B(12)-INTRINSIC FACTOR COMPLEXES.REF NATURE V. 464 445 2010REFN ISSN 0028-0836PMID 20237569DOI 10.1038/NATURE08874 Variant Set Distributions Mapped Variants
General Structure Information 2adb PTBP1 solution structure of polypyrimidine tract binding protein rbd2 complexed with cucucu rna -1.0Å AUTH F.C.OBERSTRASS,S.D.AUWETER,M.ERAT,Y.HARGOUS,AUTH 2 A.HENNING,P.WENTER,L.REYMOND,B.AMIR-AHMADY,AUTH 3 S.PITSCH,D.L.BLACK,F.H.T.ALLAINTITL STRUCTURE OF PTB BOUND TO RNA: SPECIFIC BINDINGTITL 2 AND IMPLICATIONS FOR SPLICING REGULATIONREF SCIENCE V. 309 2054 2005REFN ISSN 0036-8075PMID 16179478DOI 10.1126/SCIENCE.1114066 Variant Set Distributions Mapped Variants
General Structure Information 2b49 PTPN3 crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3 1.54Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1w2c ITPKA human inositol (1,4,5) trisphosphate 3-kinase complexed with mn2+/amppnp/ins(1,4,5)p3 1.95Å AUTH B.GONZALEZ,M.J.SCHELL,A.J.LETCHER,D.B.VEPRINTSEV,R.F.IRVINE,AUTH 2 R.L.WILLIAMSTITL STRUCTURE OF A HUMAN INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE;TITL 2 SUBSTRATE BINDING REVEALS WHY IT IS NOT A PHOSPHOINOSITIDETITL 3 3-KINASEREF MOL.CELL V. 15 689 2004REFN ISSN 1097-2765PMID 15350214DOI 10.1016/J.MOLCEL.2004.08.004 Variant Set Distributions Mapped Variants
General Structure Information 1h9o PIK3R1 phosphatidylinositol 3-kinase, p85-alpha subunit: c-terminal sh2 domain complexed with a tyr751 phosphopeptide from the pdgf receptor, crystal structure at 1.79 a 1.79Å AUTH R.A.PAUPTIT,C.A.DENNIS,D.J.DERBYSHIRE,A.L.BREEZE,AUTH 2 S.A.WESTON,S.ROWSELL,G.N.MURSHUDOVTITL NMR TRIAL MODELS: EXPERIENCES WITH THE COLICINTITL 2 IMMUNITY PROTEIN IM7 AND THE P85ALPHA C-TERMINALTITL 3 SH2-PEPTIDE COMPLEXREF ACTA CRYSTALLOGR.,SECT.D V. 57 1397 2001REFN […]
General Structure Information 2y1m CBL structure of native c-cbl 2.67Å AUTH H.DOU,L.BUETOW,A.HOCK,G.J.SIBBET,K.H.VOUSDEN,D.T.HUANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION AND PHOSPHORYLATION-TITL 2 DEPENDENT ACTIVATION OF C-CBL.REF NAT.STRUCT.MOL.BIOL. V. 19 184 2012REFN ISSN 1545-9993PMID 22266821DOI 10.1038/NSMB.2231 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants