Assessment of Structural Intolerance and Durability
General Structure Information 1x5z PTPRD solution structure of the fibronectin type-iii domain of human protein tyrosine phosphatase, receptor type, d isoform 4 variant -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIBRONECTIN TYPE-IIITITL 2 DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE,TITL 3 RECEPTOR TYPE, D ISOFORM 4 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2e2x NF1 sec14 homology module of neurofibromin in complex with phosphatitylethanolamine 2.5Å AUTH S.WELTI,S.FRATERMAN,I.DANGELO,M.WILM,K.SCHEFFZEKTITL THE SEC14 HOMOLOGY MODULE OF NEUROFIBROMIN BINDSTITL 2 CELLULAR GLYCEROPHOSPHOLIPIDS: MASS SPECTROMETRYTITL 3 AND STRUCTURE OF A LIPID COMPLEXREF J.MOL.BIOL. V. 366 551 2007REFN ISSN 0022-2836PMID 17187824DOI 10.1016/J.JMB.2006.11.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2c0l SCP2 tpr domain of human pex5p in complex with human mscp2 2.3Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 3qtz CDK2 cdk2 in complex with inhibitor rc-2-36 2.0Å AUTH E.SCHONBRUNN,S.BETZI,R.ALAM,M.P.MARTIN,A.BECKER,H.HAN,AUTH 2 R.FRANCIS,R.CHAKRASALI,S.JAKKARAJ,A.KAZI,S.M.SEBTI,AUTH 3 C.L.CUBITT,A.W.GEBHARD,L.A.HAZLEHURST,J.S.TASH,G.I.GEORGTITL DEVELOPMENT OF HIGHLY POTENT AND SELECTIVE DIAMINOTHIAZOLETITL 2 INHIBITORS OF CYCLIN-DEPENDENT KINASES.REF J.MED.CHEM. V. 56 3768 2013REFN ISSN 0022-2623PMID 23600925DOI 10.1021/JM301234K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2r83 SYT1 crystal structure analysis of human synaptotagmin 1 c2a-c2b 2.7Å AUTH K.L.FUSON,M.MONTES,J.J.ROBERT,R.B.SUTTONTITL STRUCTURE OF HUMAN SYNAPTOTAGMIN 1 C2AB IN THETITL 2 ABSENCE OF CA2+ REVEALS A NOVEL DOMAIN ASSOCIATION.REF BIOCHEMISTRY V. 46 13041 2007REFN ISSN 0006-2960PMID 17956130DOI 10.1021/BI701651K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4c6f CAD crystal structure of the dihydroorotase domain of human cad bound to substrate at ph 6.5 1.26Å AUTH A.GRANDE-GARCIA,N.LALLOUS,C.DIAZ-TEJADA,S.RAMON-MAIQUESTITL STRUCTURE, FUNCTIONAL CHARACTERIZATION AND EVOLUTION OF THETITL 2 DIHYDROOROTASE DOMAIN OF HUMAN CAD.REF STRUCTURE V. 22 185 2014REFN ISSN 0969-2126PMID 24332717DOI 10.1016/J.STR.2013.10.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1t7y AZGP1 zn-alpha-2-glycoprotein; baculo-zag peg 200, no glycerol 2.8Å AUTH S.L.DELKER,A.P.WEST JR.,L.MCDERMOTT,M.W.KENNEDY,P.J.BJORKMANTITL CRYSTALLOGRAPHIC STUDIES OF LIGAND BINDING BYTITL 2 ZN-ALPHA2-GLYCOPROTEIN.REF J.STRUCT.BIOL. V. 148 205 2004REFN ISSN 1047-8477PMID 15477100DOI 10.1016/J.JSB.2004.04.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ksa TACR1 substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for nk1r -1.0Å AUTH A.GAYEN,S.K.GOSWAMI,C.MUKHOPADHYAYTITL NMR EVIDENCE OF GM1-INDUCED CONFORMATIONAL CHANGE OFTITL 2 SUBSTANCE P USING ISOTROPIC BICELLESREF BIOCHIM.BIOPHYS.ACTA 2010REFN ISSN 0006-3002PMID 20937248DOI 10.1016/J.BBAMEM.2010.09.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2z6w PPIF crystal structure of human cyclophilin d in complex with cyclosporin a 0.96Å AUTH K.KAJITANI,M.FUJIHASHI,Y.KOBAYASHI,S.SHIMIZU,Y.TSUJIMOTO,AUTH 2 K.MIKITITL CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN D IN COMPLEX WITH ITSTITL 2 INHIBITOR, CYCLOSPORIN A AT 0.96-A RESOLUTION.REF PROTEINS V. 70 1635 2008REFN ISSN 0887-3585PMID 18076075DOI 10.1002/PROT.21855 Variant Set Distributions Mapped Variants