Assessment of Structural Intolerance and Durability
General Structure Information 3oai MPZ crystal structure of the extra-cellular domain of human myelin protein zero 2.1Å AUTH Z.LIU,Y.WANG,R.S.YEDIDI,J.S.BRUNZELLE,I.A.KOVARI,J.SOHI,AUTH 2 J.KAMHOLZ,L.C.KOVARITITL CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMANTITL 2 MYELIN PROTEIN ZERO.REF PROTEINS V. 80 307 2012REFN ISSN 0887-3585PMID 21971831DOI 10.1002/PROT.23164 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1tev CMPK1 crystal structure of the human ump/cmp kinase in open conformation 2.1Å AUTH N.SEKULIC,S.ORT,M.KONRAD,A.LAVIETITL SUBSTRATE-INDUCED CONFORMATIONAL CHANGES IN HUMANTITL 2 UMP/CMP KINASE.REF J.BIOL.CHEM. V. 279 33882 2004REFN ISSN 0021-9258PMID 15163660DOI 10.1074/JBC.M401989200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1bd9 PEBP1 human phosphatidylethanolamine binding protein 2.05Å AUTH M.J.BANFIELD,J.J.BARKER,A.C.PERRY,R.L.BRADYTITL FUNCTION FROM STRUCTURE? THE CRYSTAL STRUCTURE OFTITL 2 HUMAN PHOSPHATIDYLETHANOLAMINE-BINDING PROTEINTITL 3 SUGGESTS A ROLE IN MEMBRANE SIGNAL TRANSDUCTION.REF STRUCTURE V. 6 1245 1998REFN ISSN 0969-2126PMID 9782050DOI 10.1016/S0969-2126(98)00125-7 Variant Set Distributions Mapped Variants
General Structure Information 3nmz APC crytal structure of apc complexed with asef 3.01Å AUTH Z.ZHANG,L.CHEN,L.GAO,K.LIN,G.WUTITL CRYSTAL STRUCTURE OF APC COMPLEXED WITH ASEFREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ps5 PTPN6 crystal structure of the full-length human protein tyrosine phosphatase shp-1 3.1Å AUTH W.WANG,L.LIU,X.SONG,Y.MO,C.KOMMA,H.D.BELLAMY,Z.J.ZHAO,AUTH 2 G.W.ZHOUTITL CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASETITL 2 SHP-1 IN THE OPEN CONFORMATION.REF J.CELL.BIOCHEM. V. 112 2062 2011REFN ISSN 0730-2312PMID 21465528DOI 10.1002/JCB.23125 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3ndq TCEA1 structure of human tfiis domain ii 1.93Å AUTH X.YE,A.GNATT,X.P.HUTITL STRUCTURE OF HUMAN TFIIS DOMAIN IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2oph DPP4 human dipeptidyl peptidase iv in complex with an alpha amino acid inhibitor 2.4Å AUTH J.L.DUFFY,B.A.KIRK,L.WANG,G.J.EIERMANN,H.HE,B.LEITING,AUTH 2 K.A.LYONS,R.A.PATEL,S.B.PATEL,A.PETROV,G.SCAPIN,J.K.WU,AUTH 3 N.A.THORNBERRY,A.E.WEBERTITL 4-AMINOPHENYLALANINE AND 4-AMINOCYCLOHEXYLALANINETITL 2 DERIVATIVES AS POTENT, SELECTIVE, AND ORALLY BIOAVAILABLETITL 3 INHIBITORS OF DIPEPTIDYL PEPTIDASE IV.REF BIOORG.MED.CHEM.LETT. V. 17 2879 2007REFN ISSN 0960-894XPMID 17350841DOI 10.1016/J.BMCL.2007.02.066 Variant Set Distributions Ripley’s K […]
General Structure Information 3zon TYK2 human tyk2 pseudokinase domain bound to a kinase inhibitor 2.15Å AUTH J.M.ELKINS,J.WANG,T.KROJER,P.SAVITSKY,R.CHALK,N.DAGA,AUTH 2 E.SALAH,G.BERRIDGE,S.PICAUD,F.VON DELFT,C.BOUNTRA,A.EDWARDS,AUTH 3 S.KNAPPTITL HUMAN TYK2 PSEUDOKINASE DOMAIN BOUND TO A KINASE INHIBITORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3n8i ACP1 crystal structure of the a isoform of human cytoplasmic protein tyrosine phosphatase (hcptp-a) in complex with 1-naphtylacetic acid 1.5Å AUTH K.T.HOMAN,D.BALASUBRAMANIAM,C.V.STAUFFACHERTITL STRUCTURAL CHARACTERIZATION OF A SECONDARY BINDING SITE ONTITL 2 LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1c25 CDC25A human cdc25a catalytic domain 2.3Å AUTH E.B.FAUMAN,J.P.COGSWELL,B.LOVEJOY,W.J.ROCQUE,AUTH 2 W.HOLMES,V.G.MONTANA,H.PIWNICA-WORMS,M.J.RINK,AUTH 3 M.A.SAPERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THETITL 2 HUMAN CELL CYCLE CONTROL PHOSPHATASE, CDC25A.REF CELL(CAMBRIDGE,MASS.) V. 93 617 1998REFN ISSN 0092-8674PMID 9604936DOI 10.1016/S0092-8674(00)81190-3 Variant Set Distributions Mapped Variants