Assessment of Structural Intolerance and Durability
General Structure Information 4dg4 PRSS3 human mesotrypsin-s39y complexed with bovine pancreatic trypsin inhibitor (bpti) 1.4Å AUTH M.A.SALAMEH,A.S.SOARES,A.ALLOY,E.S.RADISKYTITL PRESENCE VERSUS ABSENCE OF HYDROGEN BOND DONOR TYR-39TITL 2 INFLUENCES INTERACTIONS OF CATIONIC TRYPSIN AND MESOTRYPSINTITL 3 WITH PROTEIN PROTEASE INHIBITORS.REF PROTEIN SCI. V. 21 1103 2012REFN ISSN 0961-8368PMID 22610453DOI 10.1002/PRO.2097 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2jrz KDM5C solution structure of the bright/arid domain from the human jarid1c protein. -1.0Å AUTH C.KOEHLER,S.BISHOP,E.F.DOWLER,P.SCHMIEDER,A.DIEHL,AUTH 2 H.OSCHKINAT,L.J.BALLTITL BACKBONE AND SIDECHAIN 1H, 13C AND 15N RESONANCETITL 2 ASSIGNMENTS OF THE BRIGHT/ARID DOMAIN FROM THETITL 3 HUMAN JARID1C (SMCX) PROTEIN.REF BIOMOL.NMR ASSIGN. V. 2 9 2008REFN ISSN 1874-2718PMID 19636912DOI 10.1007/S12104-007-9071-7 Variant Set Distributions […]
General Structure Information 2xyn ABL2 human abl2 in complex with aurora kinase inhibitor vx-680 2.81Å AUTH E.SALAH,E.UGOCHUKWU,A.J.BARR,F.VON DELFT,S.KNAPP,AUTH 2 J.M.ELKINSTITL CRYSTAL STRUCTURES OF ABL-RELATED GENE (ABL2) INTITL 2 COMPLEX WITH IMATINIB, TOZASERTIB (VX-680), AND ATITL 3 TYPE I INHIBITOR OF THE TRIAZOLE CARBOTHIOAMIDETITL 4 CLASS.REF J.MED.CHEM. V. 54 2359 2011REFN ISSN 0022-2623PMID 21417343DOI 10.1021/JM101506N Variant […]
General Structure Information 7pck CTSK crystal structure of wild type human procathepsin k 3.2Å AUTH J.SIVARAMAN,M.LALUMIERE,R.MENARD,M.CYGLERTITL CRYSTAL STRUCTURE OF WILD-TYPE HUMAN PROCATHEPSINTITL 2 K.REF PROTEIN SCI. V. 8 283 1999REFN ISSN 0961-8368PMID 10048321 Variant Set Distributions Mapped Variants
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 3kfd TGFBR1 ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 3.0Å AUTH S.RADAEV,Z.ZOU,T.HUANG,E.M.LAFER,A.P.HINCK,P.D.SUNTITL TERNARY COMPLEX OF TRANSFORMING GROWTH FACTOR-BETA1 REVEALSTITL 2 ISOFORM-SPECIFIC LIGAND RECOGNITION AND RECEPTORTITL 3 RECRUITMENT IN THE SUPERFAMILY.REF J.BIOL.CHEM. V. 285 14806 2010REFN ISSN 0021-9258PMID 20207738DOI 10.1074/JBC.M109.079921 Variant Set Distributions Mapped Variants
General Structure Information 1hzn CCKAR nmr solution structure of the third extracellular loop of the cholecystokinin a receptor -1.0Å AUTH C.GIRAGOSSIAN,D.F.MIERKETITL INTERMOLECULAR INTERACTIONS BETWEENTITL 2 CHOLECYSTOKININ-8 AND THE THIRD EXTRACELLULAR LOOPTITL 3 OF THE CHOLECYSTOKININ A RECEPTOR.REF BIOCHEMISTRY V. 40 3804 2001REFN ISSN 0006-2960PMID 11300760DOI 10.1021/BI002659N Variant Set Distributions Mapped Variants
General Structure Information 3fdt CBX5 crystal structure of the complex of human chromobox homolog 5 (cbx5) with h3k9(me)3 peptide 2.0Å AUTH L.KAUSTOV,H.OUYANG,M.AMAYA,A.LEMAK,N.NADY,S.DUAN,G.A.WASNEY,AUTH 2 Z.LI,M.VEDADI,M.SCHAPIRA,J.MIN,C.H.ARROWSMITHTITL RECOGNITION AND SPECIFICITY DETERMINANTS OF THE HUMAN CBXTITL 2 CHROMODOMAINS.REF J.BIOL.CHEM. V. 286 521 2011REFN ISSN 0021-9258PMID 21047797DOI 10.1074/JBC.M110.191411 Variant Set Distributions Mapped Variants
General Structure Information 3eyc LCN1 new crystal structure of human tear lipocalin in complex with 1,4-butanediol in space group p21 2.6Å AUTH D.A.BREUSTEDT,L.CHATWELL,A.SKERRATITL A NEW CRYSTAL FORM OF HUMAN TEAR LIPOCALIN REVEALSTITL 2 HIGH FLEXIBILITY IN THE LOOP REGION AND INDUCED FITTITL 3 IN THE LIGAND CAVITYREF ACTA CRYSTALLOGR.,SECT.D V. 65 1118 2009REFN ISSN 0907-4449PMID […]
General Structure Information 2i3c ASPA crystal structure of an aspartoacylase from homo sapiens 2.8Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,J.G.MCCOY,AUTH 2 G.N.PHILLIPSTITL STRUCTURE OF ASPARTOACYLASE, THE BRAIN ENZYMETITL 2 IMPAIRED IN CANAVAN DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 104 456 2007REFN ISSN 0027-8424PMID 17194761DOI 10.1073/PNAS.0607817104 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants