Assessment of Structural Intolerance and Durability
General Structure Information 2x4x BRPF1 molecular basis of histone h3k36me3 recognition by the pwwp domain of brpf1. 1.85Å AUTH A.VEZZOLI,N.BONADIES,M.D.ALLEN,S.M.V.FREUND,AUTH 2 C.M.SANTIVERI,B.KVINLAUG,B.J.P.HUNTLY,B.GOTTGENS,AUTH 3 M.BYCROFTTITL MOLECULAR BASIS OF HISTONE H3K36ME3 RECOGNITION BYTITL 2 THE PWWP DOMAIN OF BRPF1.REF NAT.STRUCT.MOL.BIOL. V. 17 617 2010REFN ISSN 1545-9993PMID 20400950DOI 10.1038/NSMB.1797 Variant Set Distributions Mapped Variants
General Structure Information 3efh PRPS1 crystal structure of human phosphoribosyl pyrophosphate synthetase 1 2.6Å AUTH X.PENG,X.LITITL CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLTITL 2 PYROPHOSPHATE SYNTHETASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3zrt DLG4 crystal structure of human psd-95 pdz1-2 3.4Å AUTH A.BACH,B.H.CLAUSEN,M.MOLLER,B.VESTERGAARD,C.N.CHI,A.ROUND,AUTH 2 P.L.SORENSEN,K.B.NISSEN,J.S.KASTRUP,M.GAJHEDE,P.JEMTH,AUTH 3 A.S.KRISTENSEN,P.LUNDSTROM,K.L.LAMBERTSEN,K.STROMGAARDTITL A HIGH-AFFINITY, DIMERIC INHIBITOR OF PSD-95 BIVALENTLYTITL 2 INTERACTS WITH PDZ1-2 AND PROTECTS AGAINST ISCHEMIC BRAINTITL 3 DAMAGE.REF PROC.NATL.ACAD.SCI.USA V. 109 3317 2012REFN ISSN 0027-8424PMID 22343531DOI 10.1073/PNAS.1113761109 Variant Set Distributions Mapped Variants
General Structure Information 1syx TXNL4A the crystal structure of a binary u5 snrnp complex 2.35Å AUTH T.K.NIELSEN,S.LIU,R.LUHRMANN,R.FICNERTITL STRUCTURAL BASIS FOR THE BIFUNCTIONALITY OF THE U5 SNRNP 52KTITL 2 PROTEIN (CD2BP2).REF J.MOL.BIOL. V. 369 902 2007REFN ISSN 0022-2836PMID 17467737DOI 10.1016/J.JMB.2007.03.077 Variant Set Distributions Mapped Variants
General Structure Information 2yuv MYBPC1 solution structure of 2nd immunoglobulin domain of slow type myosin-binding protein c -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF 2ND IMMUNOGLOBULIN DOMAIN OFTITL 2 SLOW TYPE MYOSIN-BINDING PROTEIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3n5u PPP1CA crystal structure of an rb c-terminal peptide bound to the catalytic subunit of pp1 3.2Å AUTH A.HIRSCHI,M.CECCHINI,R.C.STEINHARDT,M.R.SCHAMBER,F.A.DICK,AUTH 2 S.M.RUBINTITL AN OVERLAPPING KINASE AND PHOSPHATASE DOCKING SITE REGULATESTITL 2 ACTIVITY OF THE RETINOBLASTOMA PROTEIN.REF NAT.STRUCT.MOL.BIOL. V. 17 1051 2010REFN ISSN 1545-9993PMID 20694007DOI 10.1038/NSMB.1868 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3qb1 IL2 interleukin-2 mutant d10 3.1Å AUTH A.M.LEVIN,D.L.BATES,A.M.RING,C.KRIEG,J.T.LIN,L.SU,I.MORAGA,AUTH 2 M.E.RAEBER,G.R.BOWMAN,P.NOVICK,V.S.PANDE,C.G.FATHMAN,AUTH 3 O.BOYMAN,K.C.GARCIATITL EXPLOITING A NATURAL CONFORMATIONAL SWITCH TO ENGINEER ANTITL 2 INTERLEUKIN-2 SUPERKINEREF NATURE V. 484 529 2012REFN ISSN 0028-0836PMID 22446627DOI 10.1038/NATURE10975 Variant Set Distributions Mapped Variants
General Structure Information 3edv SPTBN1 crystal structure of repeats 14-16 of beta2-spectrin 1.95Å AUTH L.DAVIS,K.ABDI,M.MACHIUS,C.BRAUTIGAM,D.R.TOMCHICK,AUTH 2 V.BENNETT,P.MICHAELYTITL LOCALIZATION AND STRUCTURE OF THE ANKYRIN-BINDINGTITL 2 SITE ON BETA2-SPECTRINREF J.BIOL.CHEM. V. 284 6982 2009REFN ISSN 0021-9258PMID 19098307DOI 10.1074/JBC.M809245200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c35 POLR2G subunits rpb4 and rpb7 of human rna polymerase ii 2.7Å AUTH H.MEKA,F.WERNER,S.C.CORDELL,S.ONESTI,P.BRICKTITL CRYSTAL STRUCTURE AND RNA BINDING OF THE RPB4/RPB7TITL 2 SUBUNITS OF HUMAN RNA POLYMERASE II.REF NUCLEIC ACIDS RES. V. 33 6435 2005REFN ISSN 0305-1048PMID 16282592DOI 10.1093/NAR/GKI945 Variant Set Distributions Mapped Variants
General Structure Information 2iu1 EIF5 crystal structure of eif5 c-terminal domain 1.8Å AUTH C.BIENIOSSEK,P.SCHUTZ,M.BUMANN,A.LIMACHER,I.USON,AUTH 2 U.BAUMANNTITL THE CRYSTAL STRUCTURE OF THE CARBOXY-TERMINALTITL 2 DOMAIN OF HUMAN TRANSLATION INITIATION FACTORTITL 3 EIF5.REF J.MOL.BIOL. V. 360 457 2006REFN ISSN 0022-2836PMID 16781736DOI 10.1016/J.JMB.2006.05.021 Variant Set Distributions Mapped Variants