Assessment of Structural Intolerance and Durability
General Structure Information 1j7v IL10RA human il-10 / il-10r1 complex 2.9Å AUTH K.JOSEPHSON,N.J.LOGSDON,M.R.WALTERTITL CRYSTAL STRUCTURE OF THE IL-10/IL-10R1 COMPLEXTITL 2 REVEALS A SHARED RECEPTOR BINDING SITE.REF IMMUNITY V. 15 35 2001REFN ISSN 1074-7613PMID 11485736DOI 10.1016/S1074-7613(01)00169-8 Variant Set Distributions Mapped Variants
General Structure Information 1fyv TLR1 crystal structure of the tir domain of human tlr1 2.9Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,AUTH 2 L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Mapped Variants
General Structure Information 1fyv TLR1 crystal structure of the tir domain of human tlr1 2.9Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,AUTH 2 L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Mapped Variants
General Structure Information 1fyv TLR1 crystal structure of the tir domain of human tlr1 2.9Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,AUTH 2 L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Mapped Variants
General Structure Information 2nn6 EXOSC7 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2nn6 EXOSC2 structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 3.35Å AUTH Q.LIU,J.C.GREIMANN,C.D.LIMATITL RECONSTITUTION, ACTIVITIES, AND STRUCTURE OF THETITL 2 EUKARYOTIC RNA EXOSOME.REF CELL(CAMBRIDGE,MASS.) V. 127 1223 2006REFN ISSN 0092-8674PMID 17174896DOI 10.1016/J.CELL.2006.10.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2d7o FLNC solution structure of the 17th filamin domain from human filamin c -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 17TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3e0j POLD3 x-ray structure of the complex of regulatory subunits of human dna polymerase delta 3.0Å AUTH A.G.BARANOVSKIY,N.D.BABAYEVA,V.G.LISTON,AUTH 2 I.B.ROGOZIN,E.V.KOONIN,Y.I.PAVLOV,D.G.VASSYLYEV,AUTH 3 T.H.TAHIROVTITL X-RAY STRUCTURE OF THE COMPLEX OF REGULATORYTITL 2 SUBUNITS OF HUMAN DNA POLYMERASE DELTA.REF CELL CYCLE V. 7 3026 2008REFN ISSN 1538-4101PMID 18818516 Variant Set Distributions Mapped Variants
General Structure Information 2q8h PDK1 structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) 2.0Å AUTH M.KATO,J.LI,J.L.CHUANG,D.T.CHUANGTITL DISTINCT STRUCTURAL MECHANISMS FOR INHIBITION OF PYRUVATETITL 2 DEHYDROGENASE KINASE ISOFORMS BY AZD7545, DICHLOROACETATE,TITL 3 AND RADICICOL.REF STRUCTURE V. 15 992 2007REFN ISSN 0969-2126PMID 17683942DOI 10.1016/J.STR.2007.07.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4o2w HERC1 crystal structure of the third rcc1-like domain of herc1 2.0Å AUTH J.HU,A.DONG,Y.LI,J.R.WALKER,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE THIRD RCC1-LIKE DOMAIN OF HERC1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants