Assessment of Structural Intolerance and Durability
General Structure Information 2k2o MYOF solution structure of the inner dysf domain of human myoferlin -1.0Å AUTH P.PATEL,R.HARRIS,S.M.GEDDES,E.M.STREHLE,J.D.WATSON,AUTH 2 R.BASHIR,K.BUSHBY,P.C.DRISCOLL,N.H.KEEPTITL SOLUTION STRUCTURE OF THE INNER DYSF DOMAIN OFTITL 2 MYOFERLIN AND IMPLICATIONS FOR LIMB GIRDLETITL 3 MUSCULAR DYSTROPHY TYPE 2B.REF J.MOL.BIOL. V. 379 981 2008REFN ISSN 0022-2836PMID 18495154DOI 10.1016/J.JMB.2008.04.046 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1wh1 PDZRN3 solution structure of the fourth pdz domain of kiaa1095 protein -1.0Å AUTH X.QIN,K.SAITO,T.KIGAWA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FOURTH PDZ DOMAIN OFTITL 2 KIAA1095 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2g6b RAB26 crystal structure of human rab26 in complex with a gtp analogue 2.0Å AUTH J.WANG,W.TEMPEL,Y.SHEN,L.SHEN,D.YANIW,C.ARROWSMITH,AUTH 2 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB26 IN COMPLEX WITH ATITL 2 GTP ANALOGUEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4doh IL20RA il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4doh IL20 il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3u9j FBXL5 crystal structure of oxidized human fbxl5 hemerythrin like domain 1.6Å AUTH C.SHU,M.W.SUNG,M.D.STEWART,T.I.IGUMENOVA,X.TAN,P.LITITL THE STRUCTURAL BASIS OF IRON SENSING BY THE HUMAN F-BOXTITL 2 PROTEIN FBXL5.REF CHEMBIOCHEM V. 13 788 2012REFN ISSN 1439-4227PMID 22492618DOI 10.1002/CBIC.201200043 Variant Set Distributions Mapped Variants
General Structure Information 2dae TAB2 solution structure of the n-terminal cue domain in the human mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (map3k7ip2) -1.0Å AUTH C.ZHAO,T.KIGAWA,M.SATO,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE N-TERMINAL CUE DOMAIN INTITL 2 THE HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASETITL 3 KINASE 7 INTERACTING PROTEIN 2 (MAP3K7IP2)REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3jtc PROCR importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins 1.6Å AUTH K.VADIVEL,S.AGAH,A.S.MESSER,D.CASCIO,M.S.BAJAJ,AUTH 2 S.KRISHNASWAMY,C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL STRUCTURAL AND FUNCTIONAL STUDIES OF GAMMA-CARBOXYGLUTAMICTITL 2 ACID DOMAINS OF FACTOR VIIA AND ACTIVATED PROTEIN C: ROLE OFTITL 3 MAGNESIUM AT PHYSIOLOGICAL CALCIUM.REF J.MOL.BIOL. V. […]
General Structure Information 2box EMR2 egf domains 1,2,5 of human emr2, a 7-tm immune system molecule, in complex with strontium. 2.5Å AUTH R.J.M.ABBOTT,I.SPENDLOVE,P.ROVERSI,H.FITZGIBBON,V.KNOTT,AUTH 2 P.TERIETE,J.M.MCDONNELL,P.A.HANDFORD,S.M.LEATITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A NOVEL TTITL 2 CELL RECEPTOR CO-REGULATORY PROTEIN COMPLEX, CD97-CD55.REF J.BIOL.CHEM. V. 282 22023 2007REFN ISSN 0021-9258PMID 17449467DOI 10.1074/JBC.M702588200 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3qnt NPC1L1 npc1l1 (ntd) structure 2.83Å AUTH H.J.KWON,M.PALNITKAR,J.DEISENHOFERTITL THE STRUCTURE OF THE NPC1L1 N-TERMINAL DOMAIN IN A CLOSEDTITL 2 CONFORMATION.REF PLOS ONE V. 6 E1872 2011REFN ESSN 1932-6203PMID 21525977DOI 10.1371/JOURNAL.PONE.0018722 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants