Assessment of Structural Intolerance and Durability
General Structure Information 2yuy ARHGAP21 solution structure of pdz domain of rho gtpase activating protein 21 -1.0Å AUTH T.N.NIRAULA,M.YONEYAMA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF PDZ DOMAIN OF RHO GTPASETITL 2 ACTIVATING PROTEIN 21REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y5c FDX1L structure of human ferredoxin 2 (fdx2)in complex with 2fe2s cluster 1.7Å AUTH H.WEBERT,A.HOBLER,A.D.SHEFTEL,S.MOLIK,M.MAESTRE-REYNA,AUTH 2 L.-O.ESSEN,D.VORNISCESCU,M.KEUSGEN,F.HANNEMANN,R.BERNHARDT,AUTH 3 R.LILLTITL STRUCTURE AND FUNCTIONAL STUDIES ON HUMAN MITOCHONDRIALTITL 2 FERREDOXINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ae8 THEM4 crystal structure of human them4 1.59Å AUTH E.ZHURAVLEVA,H.GUT,D.HYNX,D.MARCELLIN,C.K.E.BLECK,C.GENOUD,AUTH 2 P.CRON,J.J.KEUSCH,B.DUMMLER,M.D.ESPOSTI,B.A.HEMMINGSTITL ACYL COENZYME A THIOESTERASE THEM5/ACOT15 IS INVOLVED INTITL 2 CARDIOLIPIN REMODELING AND FATTY LIVER DEVELOPMENT.REF MOL.CELL.BIOL. V. 32 2685 2012REFN ISSN 0270-7306PMID 22586271DOI 10.1128/MCB.00312-12 Variant Set Distributions Mapped Variants
General Structure Information 3v33 ZC3H12A crystal structure of mcpip1 conserved domain with zinc-finger motif 2.0Å AUTH J.XU,W.PENG,Y.SUN,X.WANG,Y.XU,X.LI,G.GAO,Z.RAOTITL STRUCTURAL STUDY OF MCPIP1 N-TERMINAL CONSERVED DOMAINTITL 2 REVEALS A PIN-LIKE RNASEREF NUCLEIC ACIDS RES. V. 40 6957 2012REFN ISSN 0305-1048PMID 22561375DOI 10.1093/NAR/GKS359 Variant Set Distributions Mapped Variants
General Structure Information 3t3s CYP2A13 human cytochrome p450 2a13 in complex with pilocarpine 3.0Å AUTH N.M.DEVORE,K.M.MENEELY,A.G.BART,E.S.STEPHENS,K.P.BATTAILE,AUTH 2 E.E.SCOTTTITL STRUCTURAL COMPARISON OF CYTOCHROMES P450 2A6, 2A13, AND 2E1TITL 2 WITH PILOCARPINE.REF FEBS J. V. 279 1621 2012REFN ISSN 1742-464XPMID 22051186DOI 10.1111/J.1742-4658.2011.08412.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1urf PKN1 hr1b domain from prk1 -1.0Å AUTH D.OWEN,P.N.LOWE,D.NIETLISPACH,C.E.BROSNAN,AUTH 2 D.Y.CHIRGADZE,P.J.PARKER,T.L.BLUNDELL,H.R.MOTTTITL MOLECULAR DISSECTION OF THE INTERACTION BETWEENTITL 2 THE SMALL G PROTEINS RAC1 AND RHOA AND PROTEINTITL 3 KINASE C-RELATED KINASE 1 (PRK1)REF J.BIOL.CHEM. V. 278 50578 2003REFN ISSN 0021-9258PMID 14514689DOI 10.1074/JBC.M304313200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2coc FGD3 solution structure of the c-terminal ph domain of fyve, rhogef and ph domain containing protein 3 (fgd3) from human -1.0Å AUTH H.LI,T.TOMIZAWA,N.TOCHIO,Y.MUTO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL PH DOMAIN OFTITL 2 FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3TITL 3 (FGD3) FROM HUMANREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3bpt HIBCH crystal structure of human beta-hydroxyisobutyryl-coa hydrolase in complex with quercetin 1.5Å AUTH E.S.PILKA,C.PHILLIPS,O.N.F.KING,K.GUO,F.VON DELFT,AUTH 2 A.C.W.PIKE,C.H.ARROWSMITH,J.WEIGELT,A.M.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-HYDROXYISOBUTYRYL-COATITL 2 HYDROLASE IN COMPLEX WITH QUERCETIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4asc KLHL40 crystal structure of the kelch domain of human kbtbd5 1.78Å AUTH P.CANNING,C.D.O.COOPER,T.KROJER,J.W.MURRAY,A.C.W.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,B.D.MARSDEN,AUTH 3 O.GILEADI,S.KNAPP,F.VON DELFT,A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 ASSEMBLY WITH THE BTB-KELCHTITL 2 FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2z4f DDR2 solution structure of the discoidin domain of ddr2 -1.0Å AUTH O.ICHIKAWA,M.OSAWA,N.NISHIDA,N.GOSHIMA,N.NOMURA,AUTH 2 I.SHIMADATITL STRUCTURAL BASIS OF THE COLLAGEN-BINDING MODE OFTITL 2 DISCOIDIN DOMAIN RECEPTOR 2REF EMBO J. V. 26 4168 2007REFN ISSN 0261-4189PMID 17703188DOI 10.1038/SJ.EMBOJ.7601833 Variant Set Distributions Mapped Variants