Assessment of Structural Intolerance and Durability
General Structure Information 3ljw PBRM1 crystal structure of the second bromodomain of human polybromo 1.5Å AUTH Z.CHARLOP-POWERS,L.ZENG,Q.ZHANG,M.M.ZHOUTITL STRUCTURAL INSIGHTS INTO SELECTIVE HISTONE H3 RECOGNITIONTITL 2 BY THE HUMAN POLYBROMO BROMODOMAIN 2.REF CELL RES. V. 20 529 2010REFN ISSN 1001-0602PMID 20368734DOI 10.1038/CR.2010.43 Variant Set Distributions Mapped Variants
General Structure Information 1u6g CAND1 crystal structure of the cand1-cul1-roc1 complex 3.1Å AUTH S.J.GOLDENBERG,T.C.CASCIO,S.D.SHUMWAY,K.C.GARBUTT,AUTH 2 J.LIU,Y.XIONG,N.ZHENGTITL STRUCTURE OF THE CAND1-CUL1-ROC1 COMPLEX REVEALSTITL 2 REGULATORY MECHANISMS FOR THE ASSEMBLY OF THETITL 3 MULTISUBUNIT CULLIN-DEPENDENT UBIQUITIN LIGASESREF CELL(CAMBRIDGE,MASS.) V. 119 517 2004REFN ISSN 0092-8674PMID 15537541DOI 10.1016/J.CELL.2004.10.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2dnz RBM23 solution structure of the second rna binding domain of rna binding motif protein 23 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND RNA BINDINGTITL 2 DOMAIN OF RNA BINDING MOTIF PROTEIN 23REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bbp GCC2 rab6-gtp:gcc185 rab binding domain complex 3.0Å AUTH A.S.BURGUETE,T.D.FENN,A.T.BRUNGER,S.R.PFEFFERTITL RAB AND ARL GTPASE FAMILY MEMBERS COOPERATE IN THETITL 2 LOCALIZATION OF THE GOLGIN GCC185.REF CELL(CAMBRIDGE,MASS.) V. 132 286 2008REFN ISSN 0092-8674PMID 18243103DOI 10.1016/J.CELL.2007.11.048 Variant Set Distributions Mapped Variants
General Structure Information 3hf1 RRM2B crystal structure of human p53r2 2.6Å AUTH P.SMITH,B.ZHOU,N.HO,Y.C.YUAN,L.SU,S.C.TSAI,Y.YENTITL 2.6 A X-RAY CRYSTAL STRUCTURE OF HUMAN P53R2, ATITL 2 P53-INDUCIBLE RIBONUCLEOTIDE REDUCTASE .REF BIOCHEMISTRY V. 48 11134 2009REFN ISSN 0006-2960PMID 19728742DOI 10.1021/BI9001425 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ekg DOT1L crystal structure of dot1l in complex with epz003696 2.8Å AUTH A.BASAVAPATHRUNI,L.JIN,S.R.DAIGLE,C.R.MAJER,C.A.THERKELSEN,AUTH 2 T.J.WIGLE,K.W.KUNTZ,R.CHESWORTH,R.M.POLLOCK,M.P.SCOTT,AUTH 3 M.P.MOYER,V.M.RICHON,R.A.COPELAND,E.J.OLHAVATITL CONFORMATIONAL ADAPTATION DRIVES POTENT, SELECTIVE ANDTITL 2 DURABLE INHIBITION OF THE HUMAN PROTEIN METHYLTRANSFERASETITL 3 DOT1L.REF CHEM.BIOL.DRUG DES. V. 80 971 2012REFN ISSN 1747-0277PMID 22978415DOI 10.1111/CBDD.12050 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2wqm NEK7 structure of apo human nek7 2.1Å AUTH M.W.RICHARDS,L.OREGAN,C.MAS-DROUX,J.M.Y.BLOT,AUTH 2 J.CHEUNG,S.HOELDER,A.M.FRY,R.BAYLISSTITL AN AUTO-INHIBITORY TYROSINE MOTIF IN THE CELL-TITL 2 CYCLE REGULATED NEK7 KINASE IS RELEASED THROUGHTITL 3 BINDING OF NEK9REF MOL.CELL V. 36 560 2009REFN ISSN 1097-2765PMID 19941817DOI 10.1016/J.MOLCEL.2009.09.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4crh SHKBP1 crystal structure of the btb-t1 domain of human shkbp1 1.72Å AUTH D.M.PINKAS,N.SOLCAN,T.KROJER,S.GOUBIN,E.P.WILLIAMS,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE BTB-T1 DOMAIN OF HUMAN SHKBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ndy APITD1 human mhf1-mhf2 dna complex 7.0Å AUTH Q.ZHAO,D.SARO,A.SACHPATZIDIS,T.R.SINGH,D.SCHLINGMAN,AUTH 2 X.F.ZHENG,A.MACK,M.S.TSAI,S.MOCHRIE,L.REGAN,A.R.MEETEI,AUTH 3 P.SUNG,Y.XIONGTITL THE MHF COMPLEX SENSES BRANCHED DNA BY BINDING A PAIR OFTITL 2 CROSSOVER DNA DUPLEXES.REF NAT COMMUN V. 5 2987 2014REFN ESSN 2041-1723PMID 24390579DOI 10.1038/NCOMMS3987 Variant Set Distributions Mapped Variants
General Structure Information 2daz INADL solution structure of the 7th pdz domain of inad-like protein -1.0Å AUTH K.INOUE,T.NAGASHIMA,K.IZUMI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 7TH PDZ DOMAIN OFTITL 2 INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants