Assessment of Structural Intolerance and Durability
General Structure Information 2yrh ZNF473 solution structure of the c2h2-type zinc finger domain (699- 729) from zinc finger protein 473 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2-TYPE ZINC FINGERTITL 2 DOMAIN (699-729) FROM ZINC FINGER PROTEIN 473REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2nms CD300LF the crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells irem-1 2.6Å AUTH J.A.MARQUEZ,E.GALFRE,F.DUPEUX,D.FLOT,O.MORAN,AUTH 2 N.DIMASITITL THE CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAINTITL 2 OF THE INHIBITOR RECEPTOR EXPRESSED ON MYELOIDTITL 3 CELLS IREM-1.REF J.MOL.BIOL. V. 367 310 2007REFN ISSN 0022-2836PMID 17275839DOI 10.1016/J.JMB.2007.01.011 Variant Set […]
General Structure Information 3eo2 NET1 crystal structure of the rhogef domain of human neuroepithelial cell- transforming gene 1 protein 2.6Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMANTITL 2 NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ae7 THEM5 crystal structure of human them5 1.45Å AUTH E.ZHURAVLEVA,H.GUT,D.HYNX,D.MARCELLIN,C.K.E.BLECK,C.GENOUD,AUTH 2 P.CRON,J.J.KEUSCH,B.DUMMLER,M.D.ESPOSTI,B.A.HEMMINGSTITL ACYL COENZYME A THIOESTERASE THEM5/ACOT15 IS INVOLVED INTITL 2 CARDIOLIPIN REMODELING AND FATTY LIVER DEVELOPMENT.REF MOL.CELL.BIOL. V. 32 2685 2012REFN ISSN 0270-7306PMID 22586271DOI 10.1128/MCB.00312-12 Variant Set Distributions Mapped Variants
General Structure Information 4f0d PARP16 human artd15/parp16 in complex with 3-aminobenzamide 2.7Å AUTH T.KARLBERG,A.G.THORSELL,A.KALLAS,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN ADP-RIBOSE TRANSFERASETITL 2 ARTD15/PARP16 REVEALS A NOVEL PUTATIVE REGULATORY DOMAIN.REF J.BIOL.CHEM. V. 287 24077 2012REFN ISSN 0021-9258PMID 22661712DOI 10.1074/JBC.M112.379289 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ii7 KLHL7 crystal structure of the kelch domain of human klhl7 1.63Å AUTH P.CANNING,C.D.COOPER,T.KROJER,J.W.MURRAY,A.C.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,AUTH 3 V.AYINAMPUDI,B.D.MARSDEN,O.GILEADI,S.KNAPP,F.VON DELFT,AUTH 4 A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 PROTEIN ASSEMBLY WITH THETITL 2 BTB-KELCH FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2db5 INADL solution structure of the first pdz domain of inad-like protein -1.0Å AUTH K.INOUE,C.KUROSAKI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST PDZ DOMAIN OFTITL 2 INAD-LIKE PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3nr1 HDDC3 a metazoan ortholog of spot hydrolyzes ppgpp and plays a role in starvation responses 1.9Å AUTH D.W.SUN,G.LEE,J.H.LEE,H.Y.KIM,H.W.RHEE,S.Y.PARK,K.J.KIM,AUTH 2 Y.KIM,B.Y.KIM,J.I.HONG,C.PARK,H.E.CHOY,J.H.KIM,Y.H.JEON,AUTH 3 J.CHUNGTITL A METAZOAN ORTHOLOG OF SPOT HYDROLYZES PPGPP AND FUNCTIONSTITL 2 IN STARVATION RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 17 1188 2010REFN ISSN 1545-9993PMID 20818390DOI 10.1038/NSMB.1906 Variant Set Distributions Mapped Variants
General Structure Information 2l2d OTUD7A solution nmr structure of human uba-like domain of otud7a_11_83, nesg target ht6304a/ocsp target otud7a_11_83/sgc-toronto -1.0Å AUTH B.WU,A.ASINAS,A.YEE,R.DOHERTY,A.LEMAK,A.GUTMANAS,AUTH 2 S.HOULISTON,A.SEMESI,C.H.ARROWSMITH,G.T.MONTELIONE,AUTH 3 S.DHE-PAGANONTITL THE AMINO-TERMINAL UBA DOMAIN OF OTUD7AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ys9 HOMEZ structure of the third homeodomain from the human homeobox and leucine zipper protein, homez -1.0Å AUTH S.OHNISHI,T.TOMIZAWA,S.KOSHIBA,T.HARADA,S.WATANABE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL STRUCTURE OF THE THIRD HOMEODOMAIN FROM THE HUMANTITL 2 HOMEOBOX AND LEUCINE ZIPPER PROTEIN, HOMEZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants