Assessment of Structural Intolerance and Durability
General Structure Information 2ziv EME1 crystal structure of the mus81-eme1 complex 2.7Å AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708 Variant Set Distributions Mapped Variants
General Structure Information 3cou NUDT16 crystal structure of human nudix motif 16 (nudt16) 1.8Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,C.PERSSON,J.SAGEMARK,H.SCHUELER,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,M.WELIN,J.WEIGELT,AUTH 8 M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN NUDIX MOTIF 16 (NUDT16).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4bx9 VPS33A human vps33a in complex with a fragment of human vps16 2.6Å AUTH S.C.GRAHAM,L.WARTOSCH,S.R.GRAY,E.J.SCOURFIELD,J.E.DEANE,AUTH 2 J.P.LUZIO,D.J.OWENTITL STRUCTURAL BASIS OF VPS33A RECRUITMENT TO THE HUMAN HOPSTITL 2 COMPLEX BY VPS16.REF PROC.NATL.ACAD.SCI.USA V. 110 13345 2013REFN ISSN 0027-8424PMID 23901104DOI 10.1073/PNAS.1307074110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2ecn RNF141 solution structure of the ring domain of the human ring finger protein 141 -1.0Å AUTH K.MIYAMOTO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 RING FINGER PROTEIN 141REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4akv SNX33 crystal structure of human sorting nexin 33 (snx33) 2.65Å AUTH A.OBERHOLZER,D.S.FROESE,T.KROJER,L.SHRESTHA,AUTH 2 P.FILIPPAKOPOULOS,J.R.C.MUNIZ,F.VON DELFT,C.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,C.BOUNTRA,W.W.YUETITL STRUCTURE OF HUMAN SORTING NEXIN 33REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2p82 ATG4A cysteine protease atg4a 2.1Å AUTH J.R.WALKER,T.DAVIS,S.MUJIB,C.BUTLER-COLE,P.J.FINERTY JR.,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL HUMAN CYSTEINE PROTEASE ATG4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y6l UBE2E2 human ubiquitin conjugating enzyme e2e2 1.85Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 3s8i DDI1 the retroviral-like protease (rvp) domain of human ddi1 1.7Å AUTH J.R.WALKER,A.ASINAS,A.DONG,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,S.DHE-PAGANON,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL RETROPEPSIN-LIKE DOMAIN OF HUMAN DDI1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3r0n PVRL2 crystal structure of the immunoglobulin variable domain of nectin-2 1.3Å AUTH D.SAMANTA,U.A.RAMAGOPAL,R.RUBINSTEIN,V.VIGDOROVICH,AUTH 2 S.G.NATHENSON,S.C.ALMOTITL STRUCTURE OF NECTIN-2 REVEALS DETERMINANTS OF HOMOPHILIC ANDTITL 2 HETEROPHILIC INTERACTIONS THAT CONTROL CELL-CELL ADHESION.REF PROC.NATL.ACAD.SCI.USA V. 109 14836 2012REFN ISSN 0027-8424PMID 22927415DOI 10.1073/PNAS.1212912109 Variant Set Distributions Mapped Variants
General Structure Information 1x4v ZFAND2B solution structure of the zf-an1 domain from human hypothetical protein loc130617 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-AN1 DOMAIN FROM HUMANTITL 2 HYPOTHETICAL PROTEIN LOC130617REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants