Assessment of Structural Intolerance and Durability
General Structure Information 3odx ARHGEF1 crystal structure of an n-terminally truncated linker-dh/ph domains of p115-rhogef 3.2Å AUTH Z.CHEN,L.GUO,S.R.SPRANG,P.C.STERNWEISTITL MODULATION OF A GEF SWITCH: AUTOINHIBITION OF THE INTRINSICTITL 2 GUANINE NUCLEOTIDE EXCHANGE ACTIVITY OF P115-RHOREFREF PROTEIN SCI. V. 20 107 2011REFN ISSN 0961-8368 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2vt8 PSMF1 structure of a conserved dimerisation domain within fbox7 and pi31 2.6Å AUTH R.J.KIRK,H.LAMAN,P.P.KNOWLES,J.MURRAY-RUST,AUTH 2 M.LOMONOSOV,E.K.MEZIANE,N.Q.MCDONALDTITL STRUCTURE OF A CONSERVED DIMERIZATION DOMAINTITL 2 WITHIN THE F-BOX PROTEIN FBXO7 AND THE PI31TITL 3 PROTEASOME INHIBITOR.REF J.BIOL.CHEM. V. 283 22325 2008REFN ISSN 0021-9258PMID 18495667DOI 10.1074/JBC.M709900200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2cpx RBM41 solution structure of rna binding domain in hypothetical protein flj11016 -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 HYPOTHETICAL PROTEIN FLJ11016REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2peh RBM17 crystal structure of the uhm domain of human spf45 in complex with sf3b155-ulm5 2.11Å AUTH L.CORSINI,S.BONNA,J.BASQUIN,M.HOTHORN,K.SCHEFFZEK,AUTH 2 J.VALCARCEL,M.SATTLERTITL U2AF-HOMOLOGY MOTIF INTERACTIONS ARE REQUIRED FORTITL 2 ALTERNATIVE SPLICING REGULATION BY SPF45.REF NAT.STRUCT.MOL.BIOL. V. 14 620 2007REFN ISSN 1545-9993PMID 17589525DOI 10.1038/NSMB1260 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2ou2 KAT5 acetyltransferase domain of human hiv-1 tat interacting protein, 60kda, isoform 3 2.3Å AUTH H.WU,J.MIN,L.DOMBROVSKI,P.LOPPNAU,J.WEIGELT,AUTH 2 M.SUNDSTROM,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF ACETYLTRANSFERASE DOMAINTITL 2 OF HUMAN HIV-1 TAT INTERACTING PROTEIN IN COMPLEXTITL 3 WITH ACETYLCOENZYME A.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fo5 ACOT11 human start domain of acyl-coenzyme a thioesterase 11 (acot11) 2.0Å AUTH A.G.THORSELL,W.H.LEE,C.PERSSON,M.I.SIPONEN,M.NILSSON,AUTH 2 R.D.BUSAM,T.KOTENYOVA,H.SCHULER,L.LEHTIOTITL COMPARATIVE STRUCTURAL ANALYSIS OF LIPID BINDING STARTTITL 2 DOMAINS.REF PLOS ONE V. 6 19521 2011REFN ESSN 1932-6203PMID 21738568DOI 10.1371/JOURNAL.PONE.0019521 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vge PPP1R13L crystal structure of the c-terminal region of human iaspp 2.1Å AUTH R.A.ROBINSON,X.LU,E.Y.JONES,C.SIEBOLDTITL BIOCHEMICAL AND STRUCTURAL STUDIES OF ASPPTITL 2 PROTEINS REVEAL DIFFERENTIAL BINDING TO P53, P63TITL 3 AND P73REF STRUCTURE V. 16 259 2008REFN ISSN 0969-2126PMID 18275817DOI 10.1016/J.STR.2007.11.012 Variant Set Distributions Mapped Variants
General Structure Information 2atv RERG the crystal structure of human rerg in the gdp bound state 1.9Å AUTH A.P.TURNBULL,E.SALAH,G.SCHOCH,J.ELKINS,N.BURGESS,O.GILEADI,AUTH 2 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 3 D.DOYLETITL THE CRYSTAL STRUCTURE OF HUMAN RERG IN THE GDP BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3f1i STAM human escrt-0 core complex 2.3Å AUTH X.REN,D.P.KLOER,Y.C.KIM,R.GHIRLANDO,L.F.SAIDI,G.HUMMER,AUTH 2 J.H.HURLEYTITL HYBRID STRUCTURAL MODEL OF THE COMPLETE HUMAN ESCRT-0TITL 2 COMPLEX.REF STRUCTURE V. 17 406 2009REFN ISSN 0969-2126PMID 19278655DOI 10.1016/J.STR.2009.01.012 Variant Set Distributions Mapped Variants
General Structure Information 1so0 GALM crystal structure of human galactose mutarotase complexed with galactose 2.3Å AUTH J.B.THODEN,D.J.TIMSON,R.J.REECE,H.M.HOLDENTITL MOLECULAR STRUCTURE OF HUMAN GALACTOSE MUTAROTASEREF J.BIOL.CHEM. V. 279 23431 2004REFN ISSN 0021-9258PMID 15026423DOI 10.1074/JBC.M402347200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants