Assessment of Structural Intolerance and Durability
General Structure Information 1q33 NUDT9 crystal structure of human adp-ribose pyrophosphatase nudt9 1.81Å AUTH B.W.SHEN,A.L.PERRAUD,A.SCHARENBERG,B.L.STODDARDTITL THE CRYSTAL STRUCTURE AND MUTATIONAL ANALYSIS OFTITL 2 HUMAN NUDT9REF J.MOL.BIOL. V. 332 385 2003REFN ISSN 0022-2836PMID 12948489DOI 10.1016/S0022-2836(03)00954-9 Variant Set Distributions Mapped Variants
General Structure Information 1u7t HSD17B10 crystal structure of abad/hsd10 with a bound inhibitor 2.0Å AUTH C.R.KISSINGER,P.A.REJTO,L.A.PELLETIER,J.A.THOMSON,AUTH 2 R.E.SHOWALTER,M.A.ABREO,C.S.AGREE,S.MARGOSIAK,AUTH 3 J.J.MENG,R.M.AUST,D.VANDERPOOL,B.LI,AUTH 4 A.TEMPCZYK-RUSSELL,J.E.VILLAFRANCATITL CRYSTAL STRUCTURE OF HUMAN ABAD/HSD10 WITH A BOUNDTITL 2 INHIBITOR: IMPLICATIONS FOR DESIGN OF ALZHEIMERSTITL 3 DISEASE THERAPEUTICSREF J.MOL.BIOL. V. 342 943 2004REFN ISSN 0022-2836PMID 15342248DOI 10.1016/J.JMB.2004.07.071 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2rt5 SPEN structural insights into the recruitment of smrt by the co-repressor sharp under phosphorylative regulation -1.0Å AUTH S.MIKAMI,T.KANABA,N.TAKIZAWA,A.KOBAYASHI,R.MAESAKI,AUTH 2 T.FUJIWARA,Y.ITO,M.MISHIMATITL STRUCTURAL INSIGHTS INTO THE RECRUITMENT OF SMRT BY THETITL 2 COREPRESSOR SHARP UNDER PHOSPHORYLATIVE REGULATIONREF STRUCTURE 2013REFN ISSN 0969-2126PMID 24268649DOI 10.1016/J.STR.2013.10.007 Variant Set Distributions Mapped Variants
General Structure Information 2lqt CHCHD7 solution structure of chchd7 -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,D.JAISWAL,S.NERI,AUTH 2 R.PERUZZINI,J.WINKELMANNTITL STRUCTURAL CHARACTERIZATION OF CHCHD5 AND CHCHD7: TWOTITL 2 ATYPICAL HUMAN TWIN CX(9)C PROTEINS.REF J.STRUCT.BIOL. V. 180 190 2012REFN ISSN 1047-8477PMID 22842048DOI 10.1016/J.JSB.2012.07.007 Variant Set Distributions Mapped Variants
General Structure Information 4frw PVRL4 crystal structure of human nectin-4 extracellular fragment d1-d2 3.5Å AUTH O.J.HARRISON,J.VENDOME,J.BRASCH,X.JIN,S.HONG,P.S.KATSAMBA,AUTH 2 G.AHLSEN,R.B.TROYANOVSKY,S.M.TROYANOVSKY,B.HONIG,L.SHAPIROTITL NECTIN ECTODOMAIN STRUCTURES REVEAL A CANONICAL ADHESIVETITL 2 INTERFACE.REF NAT.STRUCT.MOL.BIOL. V. 19 906 2012REFN ISSN 1545-9993PMID 22902367DOI 10.1038/NSMB.2366 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ag5 BDH2 crystal structure of human dhrs6 1.84Å AUTH K.GUO,P.LUKACIK,E.PAPAGRIGORIOU,M.MEIER,W.H.LEE,J.ADAMSKI,AUTH 2 U.OPPERMANNTITL CHARACTERIZATION OF HUMAN DHRS6, AN ORPHAN SHORT CHAINTITL 2 DEHYDROGENASE/REDUCTASE ENZYME: A NOVEL, CYTOSOLIC TYPE 2TITL 3 R-BETA-HYDROXYBUTYRATE DEHYDROGENASEREF J.BIOL.CHEM. V. 281 10291 2006REFN ISSN 0021-9258PMID 16380372DOI 10.1074/JBC.M511346200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3f5n SERPINI1 structure of native human neuroserpin 3.15Å AUTH S.RICAGNO,S.CACCIA,G.SORRENTINO,G.ANTONINI,M.BOLOGNESITITL HUMAN NEUROSERPIN: STRUCTURE AND TIME-DEPENDENT INHIBITIONREF J.MOL.BIOL. V. 388 109 2009REFN ISSN 0022-2836PMID 19265707DOI 10.1016/J.JMB.2009.02.056 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4n4w SMO structure of the human smoothened receptor in complex with sant-1. 2.8Å AUTH C.WANG,H.WU,T.EVRON,E.VARDY,G.W.HAN,X.P.HUANG,S.J.HUFEISEN,AUTH 2 T.J.MANGANO,D.J.URBAN,V.KATRITCH,V.CHEREZOV,M.G.CARON,AUTH 3 B.L.ROTH,R.C.STEVENSTITL STRUCTURAL BASIS FOR SMOOTHENED RECEPTOR MODULATION ANDTITL 2 CHEMORESISTANCE TO ANTICANCER DRUGS.REF NAT COMMUN V. 5 4355 2014REFN ESSN 2041-1723PMID 25008467DOI 10.1038/NCOMMS5355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3h8v UBA5 human ubiquitin-activating enzyme 5 in complex with atp 2.0Å AUTH J.P.BACIK,J.R.WALKER,M.ALI,A.D.SCHIMMER,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF THE HUMAN UBIQUITIN-ACTIVATING ENZYME 5TITL 2 (UBA5) BOUND TO ATP: MECHANISTIC INSIGHTS INTO ATITL 3 MINIMALISTIC E1 ENZYME.REF J.BIOL.CHEM. V. 285 20273 2010REFN ISSN 0021-9258PMID 20368332DOI 10.1074/JBC.M110.102921 Variant Set Distributions Mapped Variants
General Structure Information 2efl FNBP1 crystal structure of the efc domain of formin-binding protein 17 2.61Å AUTH A.SHIMADA,H.NIWA,K.TSUJITA,S.SUETSUGU,K.NITTA,AUTH 2 K.HANAWA-SUETSUGU,R.AKASAKA,Y.NISHINO,M.TOYAMA,L.CHEN,AUTH 3 Z.-J.LIU,B.-C.WANG,M.YAMAMOTO,T.TERADA,A.MIYAZAWA,A.TANAKA,AUTH 4 S.SUGANO,M.SHIROUZU,K.NAGAYAMA,T.TAKENAWA,S.YOKOYAMATITL CURVED EFC/F-BAR-DOMAIN DIMERS ARE JOINED END TO END INTO ATITL 2 FILAMENT FOR MEMBRANE INVAGINATION IN ENDOCYTOSISREF CELL(CAMBRIDGE,MASS.) V. 129 761 2007REFN ISSN 0092-8674PMID 17512409DOI 10.1016/J.CELL.2007.03.040 Variant Set Distributions Ripley’s K […]