Assessment of Structural Intolerance and Durability
General Structure Information 2ckk KIN high resolution crystal structure of the human kin17 c-terminal domain containing a kow motif kin17. 1.45Å AUTH A.LE MAIRE,M.SCHILTZ,E.A.STURA,G.PINON-LATAILLADE,AUTH 2 J.COUPRIE,M.MOUTIEZ,M.GONDRY,J.F.ANGULO,AUTH 3 S.ZINN-JUSTINTITL A TANDEM OF SH3-LIKE DOMAINS PARTICIPATES IN RNATITL 2 BINDING IN KIN17, A HUMAN PROTEIN ACTIVATED INTITL 3 RESPONSE TO GENOTOXICS.REF J.MOL.BIOL. V. 364 764 2006REFN ISSN […]
General Structure Information 1uoh PSMD10 human gankyrin 2.0Å AUTH S.KRZYWDA,A.M.BRZOZOWSKI,H.HIGASHITSUJI,J.FUJITA,R.WELCHMAN,AUTH 2 S.DAWSON,R.J.MAYER,A.J.WILKINSONTITL THE CRYSTAL STRUCTURE OF GANKYRIN, AN ONCOPROTEIN FOUND INTITL 2 COMPLEXES WITH CYCLIN-DEPENDENT KINASE 4, A 19 STITL 3 PROTEASOMAL ATPASE REGULATOR, AND THE TUMOR SUPPRESSORS RBTITL 4 AND P53REF J.BIOL.CHEM. V. 279 1541 2004REFN ISSN 0021-9258PMID 14573599DOI 10.1074/JBC.M310265200 Variant Set Distributions Mapped […]
General Structure Information 2d9w DOK2 solution structure of the ph domain of docking protein 2 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF DOCKINGTITL 2 PROTEIN 2 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2d9z PRKD3 solution structure of the ph domain of protein kinase c, nu type from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PROTEINTITL 2 KINASE C, NU TYPE FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dlx UBXN7 solution structure of the uas domain of human ubx domain- containing protein 7 -1.0Å AUTH H.P.ZHANG,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE UAS DOMAIN OF HUMAN UBXTITL 2 DOMAIN-CONTAINING PROTEIN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2buj STK16 crystal structure of the human serine-threonine kinase 16 in complex with staurosporine 2.6Å AUTH J.E.DEBRECZENI,J.ESWARAN,A.BULLOCK,P.FILIPPAKOPOULOS,AUTH 2 K.KAVANAGH,A.AMOS,O.FEDOROV,F.SOBOTT,L.J.BALL,F.VON DELFT,AUTH 3 C.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16TITL 2 IN COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3puf RNASEH2A crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4bxu PEX14 structure of pex14 in complex with pex5 lvxef motif -1.0Å AUTH A.NEUHAUS,H.KOOSHAPUR,J.WOLF,H.N.MEYER,T.MADL,J.SAIDOWSKY,AUTH 2 E.HAMBRUCH,A.LASSAM,M.JUNG,M.SATTLER,W.SCHLIEBS,R.ERDMANNTITL A NOVEL PEX14 INTERACTING SITE OF HUMAN PEX5 IS CRITICALTITL 2 FOR MATRIX PROTEIN IMPORT INTO PEROXISOMES.REF J.BIOL.CHEM. V. 289 437 2014REFN ISSN 0021-9258PMID 24235149DOI 10.1074/JBC.M113.499707 Variant Set Distributions Mapped Variants
General Structure Information 2jsd MMP20 solution structure of mmp20 complexed with nngh -1.0Å AUTH Y.ARENDT,L.BANCI,I.BERTINI,F.CANTINI,R.COZZI,AUTH 2 R.DEL CONTE,L.GONNELLITITL CATALYTIC DOMAIN OF MMP20 (ENAMELYSIN) – THE NMRTITL 2 STRUCTURE OF A NEW MATRIX METALLOPROTEINASE.REF FEBS LETT. V. 581 4723 2007REFN ISSN 0014-5793PMID 17869250DOI 10.1016/J.FEBSLET.2007.08.069 Variant Set Distributions Mapped Variants
General Structure Information 2gwh SULT1C4 human sulfotranferase sult1c2 in complex with pap and pentachlorophenol 1.8Å AUTH A.ALLALI-HASSANI,P.W.PAN,L.DOMBROVSKI,R.NAJMANOVICH,AUTH 2 W.TEMPEL,A.DONG,P.LOPPNAU,F.MARTIN,J.THORNTON,J.THONTON,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,M.VEDADI,AUTH 4 C.H.ARROWSMITHTITL STRUCTURAL AND CHEMICAL PROFILING OF THE HUMAN CYTOSOLICTITL 2 SULFOTRANSFERASES.REF PLOS BIOL. V. 5 E97 2007REFN ISSN 1544-9173PMID 17425406DOI 10.1371/JOURNAL.PBIO.0050097 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]