Assessment of Structural Intolerance and Durability
General Structure Information 2lq6 BRD1 solution structure of brd1 phd2 finger -1.0Å AUTH L.LIU,S.QIN,J.ZHANG,P.JI,Y.SHI,J.WUTITL SOLUTION STRUCTURE OF AN ATYPICAL PHD FINGER IN BRPF2 ANDTITL 2 ITS INTERACTION WITH DNAREF J.STRUCT.BIOL. V. 180 165 2012REFN ISSN 1047-8477PMID 22820306DOI 10.1016/J.JSB.2012.06.014 Variant Set Distributions Mapped Variants
General Structure Information 1nl0 F9 crystal structure of human factor ix gla domain in complex of an inhibitory antibody, 10c12 2.2Å AUTH M.HUANG,B.C.FURIE,B.FURIETITL CRYSTAL STRUCTURE OF THE CALCIUM-STABILIZED HUMANTITL 2 FACTOR IX GLA DOMAIN BOUND TO ATITL 3 CONFORMATION-SPECIFIC ANTI-FACTOR IX ANTIBODY.REF J.BIOL.CHEM. V. 279 14338 2004REFN ISSN 0021-9258PMID 14722079DOI 10.1074/JBC.M314011200 Variant Set Distributions Mapped […]
General Structure Information 3ggs PNP human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoro-2-deoxyadenosine 2.52Å AUTH S.AFSHAR,M.R.SAWAYA,S.L.MORRISONTITL STRUCTURE OF A MUTANT HUMAN PURINE NUCLEOSIDE PHOSPHORYLASETITL 2 WITH THE PRODRUG, 2-FLUORO-2-DEOXYADENOSINE AND THETITL 3 CYTOTOXIC DRUG, 2-FLUOROADENINE.REF PROTEIN SCI. V. 18 1107 2009REFN ISSN 0961-8368PMID 19388075DOI 10.1002/PRO.91 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3vi3 ITGB1 crystal structure of alpha5beta1 integrin headpiece (ligand-free form) 2.9Å AUTH M.NAGAE,S.RE,E.MIHARA,T.NOGI,Y.SUGITA,J.TAKAGITITL CRYSTAL STRUCTURE OF ALPHA5BETA1 INTEGRIN ECTODOMAIN: ATOMICTITL 2 DETAILS OF THE FIBRONECTIN RECEPTORREF J.CELL BIOL. V. 197 131 2012REFN ISSN 0021-9525PMID 22451694DOI 10.1083/JCB.201111077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3r8q FN1 structure of fibronectin domain 12-14 2.4Å AUTH N.R.ZACCAI,C.AGNEW,R.L.BRADYTITL STRUCTURE OF FIBRONECTIN DOMAIN 12-14REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2l7b APOE nmr structure of full length apoe3 -1.0Å AUTH J.CHEN,Q.LI,J.WANGTITL TOPOLOGY OF HUMAN APOLIPOPROTEIN E3 UNIQUELY REGULATES ITSTITL 2 DIVERSE BIOLOGICAL FUNCTIONS.REF PROC.NATL.ACAD.SCI.USA V. 108 14813 2011REFN ISSN 0027-8424PMID 21873229DOI 10.1073/PNAS.1106420108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kq0 ORM1 crystal structure of human alpha1-acid glycoprotein 1.8Å AUTH D.L.SCHONFELD,R.B.RAVELLI,U.MUELLER,A.SKERRATITL THE 1.8-A CRYSTAL STRUCTURE OF ALPHA1-ACIDTITL 2 GLYCOPROTEIN (OROSOMUCOID) SOLVED BY UV RIP REVEALSTITL 3 THE BROAD DRUG-BINDING ACTIVITY OF THIS HUMANTITL 4 PLASMA LIPOCALIN.REF J.MOL.BIOL. V. 384 393 2008REFN ISSN 0022-2836PMID 18823996DOI 10.1016/J.JMB.2008.09.020 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2w08 APCS the structure of serum amyloid p component bound to 0- phospho-threonine 1.7Å AUTH S.E.KOLSTOE,B.H.RIDHA,V.BELLOTTI,N.WANG,AUTH 2 C.V.ROBINSON,S.J.CRUTCH,G.KEIR,R.KUKKASTENVEHMAS,AUTH 3 J.R.GALLIMORE,W.L.HUTCHINSON,P.N.HAWKINS,S.P.WOOD,AUTH 4 M.N.ROSSOR,M.B.PEPYSTITL MOLECULAR DISSECTION OF ALZHEIMERS DISEASETITL 2 NEUROPATHOLOGY BY DEPLETION OF SERUM AMYLOID PTITL 3 COMPONENT.REF PROC.NATL.ACAD.SCI.USA V. 106 7619 2009REFN ISSN 0027-8424PMID 19372378DOI 10.1073/PNAS.0902640106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2voo SSB crystal structure of n-terminal domains of human la protein complexed with rna oligomer uuuuuuuu 1.8Å AUTH O.KOTIK-KOGAN,E.R.VALENTINE,D.SANFELICE,M.R.CONTE,AUTH 2 S.CURRYTITL STRUCTURAL ANALYSIS REVEALS CONFORMATIONALTITL 2 PLASTICITY IN THE RECOGNITION OF RNA 3 ENDS BYTITL 3 THE HUMAN LA PROTEIN.REF STRUCTURE V. 16 852 2008REFN ISSN 0969-2126PMID 18547518DOI 10.1016/J.STR.2008.02.021 Variant Set Distributions […]
General Structure Information 2i1b IL1B crystallographic refinement of interleukin-1 beta at 2.0 angstroms resolution 2.0Å AUTH J.P.PRIESTLE,H.P.SCHAR,M.G.GRUTTERTITL CRYSTALLOGRAPHIC REFINEMENT OF INTERLEUKIN 1 BETATITL 2 AT 2.0 A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 86 9667 1989REFN ISSN 0027-8424PMID 2602367DOI 10.1073/PNAS.86.24.9667 Variant Set Distributions Mapped Variants