Assessment of Structural Intolerance and Durability
General Structure Information 4a9z TP63 crystal structure of human p63 tetramerization domain 2.29Å AUTH J.R.C.MUNIZ,D.COUTANDIN,E.SALAH,A.CHAIKUAD,M.VOLLMAR,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,V.DOTSCH,AUTH 3 F.VON DELFT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN P63 TETRAMERIZATION DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3vzd SPHK1 crystal structure of sphingosine kinase 1 with inhibitor and adp 2.3Å AUTH Z.WANG,X.MIN,S.H.XIAO,S.JOHNSTONE,W.ROMANOW,D.MEININGER,AUTH 2 H.XU,J.LIU,J.DAI,S.AN,S.THIBAULT,N.WALKERTITL MOLECULAR BASIS OF SPHINGOSINE KINASE 1 SUBSTRATETITL 2 RECOGNITION AND CATALYSIS.REF STRUCTURE V. 21 798 2013REFN ISSN 0969-2126PMID 23602659DOI 10.1016/J.STR.2013.02.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v4j APOBEC3G first-in-class small molecule inhibitors of the single-strand dna cytosine deaminase apobec3g 2.04Å AUTH M.LI,S.M.SHANDILYA,M.A.CARPENTER,A.RATHORE,W.L.BROWN,AUTH 2 A.L.PERKINS,D.A.HARKI,J.SOLBERG,D.J.HOOK,K.K.PANDEY,AUTH 3 M.A.PARNIAK,J.R.JOHNSON,N.J.KROGAN,M.SOMASUNDARAN,A.ALI,AUTH 4 C.A.SCHIFFER,R.S.HARRISTITL FIRST-IN-CLASS SMALL MOLECULE INHIBITORS OF THETITL 2 SINGLE-STRAND DNA CYTOSINE DEAMINASE APOBEC3G.REF ACS CHEM.BIOL. V. 7 506 2012REFN ISSN 1554-8929PMID 22181350DOI 10.1021/CB200440Y Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3ly5 DDX18 ddx18 dead-domain 2.8Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d2s MBNL1 crystal structure of mbnl1 tandem zinc finger 3 and 4 domain in complex with cgcugu rna 1.7Å AUTH M.TEPLOVA,D.J.PATELTITL STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY THETITL 2 ALTERNATIVE-SPLICING REGULATOR MUSCLEBLIND-LIKE MBNL1.REF NAT.STRUCT.MOL.BIOL. V. 15 1343 2008REFN ISSN 1545-9993PMID 19043415DOI 10.1038/NSMB.1519 Variant Set Distributions Mapped Variants
General Structure Information 2d9o DNAJC17 solution structure of rna binding domain in hypothetical protein flj10634 -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 HYPOTHETICAL PROTEIN FLJ10634REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4g1c SIRT5 human sirt5 bound to succ-idh2 and carba-nad 1.94Å AUTH B.G.SZCZEPANKIEWICZ,H.DAI,K.J.KOPPETSCH,D.QIAN,F.JIANG,AUTH 2 C.MAO,R.B.PERNITITL SYNTHESIS OF CARBA-NAD AND THE STRUCTURES OF ITS TERNARYTITL 2 COMPLEXES WITH SIRT3 AND SIRT5.REF J.ORG.CHEM. V. 77 7319 2012REFN ISSN 0022-3263PMID 22849721DOI 10.1021/JO301067E Variant Set Distributions Mapped Variants
General Structure Information 3zdq ABCB10 structure of the human mitochondrial abc transporter, abcb10 (nucleotide-free form) 2.85Å AUTH C.A.SHINTRE,A.C.W.PIKE,Q.LI,J.KIM,A.J.BARR,S.GOUBIN,AUTH 2 L.SHRESTHA,J.YANG,G.BERRIDGE,J.ROSS,P.J.STANSFELD,AUTH 3 M.S.P.SANSOM,A.M.EDWARDS,C.BOUNTRA,B.D.MARSDEN,F.VON DELFT,AUTH 4 A.N.BULLOCK,O.GILEADI,N.A.BURGESS-BROWN,E.P.CARPENTERTITL STRUCTURES OF ABCB10, A HUMAN ATP-BINDING CASSETTETITL 2 TRANSPORTER IN APO- AND NUCLEOTIDE-BOUND STATESREF PROC.NATL.ACAD.SCI.USA V. 110 9710 2013REFN ISSN 0027-8424PMID 23716676DOI 10.1073/PNAS.1217042110 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1v95 NCOA5 solution structure of anticodon binding domain from nuclear receptor coactivator 5 (human kiaa1637 protein) -1.0Å AUTH C.ZHAO,T.KIGAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF ANTICODON BINDING DOMAINTITL 2 FROM NUCLEAR RECEPTOR COACTIVATOR 5 (HUMANTITL 3 KIAA1637 PROTEIN)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x5e TMX1 the solution structure of the thioredoxin-like domain of human thioredoxin-related transmembrane protein -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIOREDOXIN-LIKETITL 2 DOMAIN OF HUMAN THIOREDOXIN-RELATED TRANSMEMBRANETITL 3 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants