Assessment of Structural Intolerance and Durability
General Structure Information 2ac3 MKNK2 structure of human mnk2 kinase domain 2.1Å AUTH R.JAUCH,S.JAKEL,C.NETTER,K.SCHREITER,B.AICHER,H.JACKLE,AUTH 2 M.C.WAHLTITL CRYSTAL STRUCTURES OF THE MNK2 KINASE DOMAIN REVEAL ANTITL 2 INHIBITORY CONFORMATION AND A ZINC BINDING SITE.REF STRUCTURE V. 13 1559 2005REFN ISSN 0969-2126PMID 16216586DOI 10.1016/J.STR.2005.07.013 Variant Set Distributions Mapped Variants
General Structure Information 2oju PPIL3 x-ray structure of complex of human cyclophilin j with cyclosporin a 2.4Å AUTH J.CHEN,S.CHEN,L.HUANG,X.ZHAO,J.TAN,C.HUANG,H.SAIYIN,M.ZHANG,AUTH 2 X.ZENG,J.XI,B.WAN,Y.ZHAO,Z.XIA,H.JIANG,Q.YI,J.O.LIU,L.YUTITL TARGETING CYCLOPHILIN J, A NOVEL PEPTIDYL-PROLYL ISOMERASE,TITL 2 CAN INDUCE CELLULAR G1/S ARREST AND REPRESS THE GROWTH OFTITL 3 HEPATOCELLULAR CARCINOMAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3q18 GSTO2 human glutathione transferase o2 1.7Å AUTH H.ZHOU,J.BROCK,D.LIU,P.G.BOARD,A.J.OAKLEYTITL STRUCTURAL INSIGHTS INTO THE DEHYDROASCORBATE REDUCTASETITL 2 ACTIVITY OF HUMAN OMEGA-CLASS GLUTATHIONE TRANSFERASES.REF J.MOL.BIOL. V. 420 190 2012REFN ISSN 0022-2836PMID 22522127DOI 10.1016/J.JMB.2012.04.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4msp FKBP14 crystal structure of human peptidyl-prolyl cis-trans isomerase fkbp22 (aka fkbp14) containing two ef-hand motifs 1.9Å AUTH S.P.BOUDKO,Y.ISHIKAWA,J.NIX,M.S.CHAPMAN,H.P.BACHINGERTITL STRUCTURE OF HUMAN PEPTIDYL-PROLYL CIS-TRANS ISOMERASETITL 2 FKBP22 CONTAINING TWO EF-HAND MOTIFS.REF PROTEIN SCI. V. 23 67 2014REFN ISSN 0961-8368PMID 24272907DOI 10.1002/PRO.2391 Variant Set Distributions Mapped Variants
General Structure Information 2hky RNASE7 nmr solution structure of human rnase 7 -1.0Å AUTH Y.C.HUANG,Y.M.LIN,T.W.CHANG,S.J.WU,Y.S.LEE,AUTH 2 M.D.CHANG,C.CHEN,S.H.WU,Y.D.LIAOTITL THE FLEXIBLE AND CLUSTERED LYSINE RESIDUES OFTITL 2 HUMAN RIBONUCLEASE 7 ARE CRITICAL FOR MEMBRANETITL 3 PERMEABILITY AND ANTIMICROBIAL ACTIVITY.REF J.BIOL.CHEM. V. 282 4626 2007REFN ISSN 0021-9258PMID 17150966DOI 10.1074/JBC.M607321200 Variant Set Distributions Mapped Variants
General Structure Information 4l1d SCN3B voltage-gated sodium channel beta3 subunit ig domain 2.5Å AUTH S.NAMADURAI,D.BALASURIYA,R.RAJAPPA,M.WIEMHOFER,K.STOTT,AUTH 2 J.KLINGAUF,J.M.EDWARDSON,D.Y.CHIRGADZE,A.P.JACKSONTITL CRYSTAL STRUCTURE AND MOLECULAR IMAGING OF THE NAV CHANNELTITL 2 BETA 3 SUBUNIT INDICATES A TRIMERIC ASSEMBLY.REF J.BIOL.CHEM. V. 289 10797 2014REFN ISSN 0021-9258PMID 24567321DOI 10.1074/JBC.M113.527994 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2y7b ANLN crystal structure of the ph domain of human actin-binding protein anillin anln 1.9Å AUTH M.VOLLMAR,J.WANG,T.KROJER,J.ELKINS,P.FILIPPAKOPOULOS,AUTH 2 E.UGOCHUKWU,R.COCKING,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE PH DOMAIN OF HUMAN ACTIN-BINDINGTITL 2 PROTEIN ANILLIN ANLNREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4cek UPF2 crystal structure of the second mif4g domain of human nonsense mediated decay factor upf2 2.35Å AUTH M.CLERICI,A.DENIAUD,V.BOEHM,N.H.GEHRING,C.SCHAFFITZEL,AUTH 2 S.CUSACKTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE THREE MIF4GTITL 2 DOMAINS OF NONSENSE-MEDIATED DECAY FACTOR UPF2.REF NUCLEIC ACIDS RES. V. 42 2673 2014REFN ISSN 0305-1048PMID 24271394DOI 10.1093/NAR/GKT1197 Variant Set Distributions Ripley’s K […]
General Structure Information 2dba UNC45A the solution structure of the tetratrico peptide repeat of human smooth muscle cell associated protein-1, isoform 2 -1.0Å AUTH N.TOCHIO,A.SASAGAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE TETRATRICO PEPTIDETITL 2 REPEAT OF HUMAN SMOOTH MUSCLE CELL ASSOCIATEDTITL 3 PROTEIN-1, ISOFORM 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cs3 IRF2BPL solution structure of the zf-c3hc4 domain of human kiaa1865 -1.0Å AUTH K.INOUE,K.SAITOH,F.HAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-C3HC4 DOMAIN OF HUMANTITL 2 KIAA1865REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants