Assessment of Structural Intolerance and Durability
General Structure Information 1apj FBN1 nmr study of the transforming growth factor beta binding protein-like domain (tb module/8-cys domain), nmr, 21 structures -1.0Å AUTH X.YUAN,A.K.DOWNING,V.KNOTT,P.A.HANDFORDTITL SOLUTION STRUCTURE OF THE TRANSFORMING GROWTHTITL 2 FACTOR BETA-BINDING PROTEIN-LIKE MODULE, A DOMAINTITL 3 ASSOCIATED WITH MATRIX FIBRILS.REF EMBO J. V. 16 6659 1997REFN ISSN 0261-4189PMID 9362480DOI 10.1093/EMBOJ/16.22.6659 Variant Set […]
General Structure Information 1kn0 RAD52 crystal structure of the human rad52 protein 2.85Å AUTH W.KAGAWA,H.KURUMIZAKA,R.ISHITANI,S.FUKAI,O.NUREKI,AUTH 2 T.SHIBATA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE HOMOLOGOUS-PAIRING DOMAINTITL 2 FROM THE HUMAN RAD52 RECOMBINASE IN THETITL 3 UNDECAMERIC FORM.REF MOL.CELL V. 10 359 2002REFN ISSN 1097-2765PMID 12191481DOI 10.1016/S1097-2765(02)00587-7 Variant Set Distributions Mapped Variants
General Structure Information 1k5g RANBP1 crystal structure of ran-gdp-alfx-ranbp1-rangap complex 3.1Å AUTH M.J.SEEWALD,C.KORNER,A.WITTINGHOFER,I.R.VETTERTITL RANGAP MEDIATES GTP HYDROLYSIS WITHOUT AN ARGININETITL 2 FINGER.REF NATURE V. 415 662 2002REFN ISSN 0028-0836PMID 11832950DOI 10.1038/415662A Variant Set Distributions Mapped Variants
General Structure Information 1qqg IRS1 crystal structure of the ph-ptb targeting region of irs-1 2.3Å AUTH S.DHE-PAGANON,E.A.OTTINGER,R.T.NOLTE,M.J.ECK,AUTH 2 S.E.SHOELSONTITL CRYSTAL STRUCTURE OF THE PLECKSTRINTITL 2 HOMOLOGY-PHOSPHOTYROSINE BINDING (PH-PTB)TITL 3 TARGETING REGION OF INSULIN RECEPTOR SUBSTRATE 1.REF PROC.NATL.ACAD.SCI.USA V. 96 8378 1999REFN ISSN 0027-8424PMID 10411883DOI 10.1073/PNAS.96.15.8378 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1i8l CD80 human b7-1/ctla-4 co-stimulatory complex 3.0Å AUTH C.C.STAMPER,Y.ZHANG,J.F.TOBIN,D.V.ERBE,S.IKEMIZU,S.J.DAVIS,AUTH 2 M.L.STAHL,J.SEEHRA,W.S.SOMERS,L.MOSYAKTITL CRYSTAL STRUCTURE OF THE B7-1/CTLA-4 COMPLEX THAT INHIBITSTITL 2 HUMAN IMMUNE RESPONSES.REF NATURE V. 410 608 2001REFN ISSN 0028-0836PMID 11279502DOI 10.1038/35069118 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2x7o TGFBR1 crystal structure of tgfbri complexed with an indolinone inhibitor 3.7Å AUTH G.J.ROTH,A.HECKEL,T.BRANDL,M.GRAUERT,S.HOERER,J.T.KLEY,AUTH 2 G.SCHNAPP,P.BAUM,D.MENNERICH,A.SCHNAPP,J.E.PARKTITL DESIGN, SYNTHESIS AND EVALUATION OF INDOLINONES ASTITL 2 INHIBITORS OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTORTITL 3 I (TGFBRI)REF J.MED.CHEM. V. 53 7287 2010REFN ISSN 0022-2623PMID 20919678DOI 10.1021/JM100812A Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1c07 EPS15 structure of the third eps15 homology domain of human eps15 -1.0Å AUTH J.L.ENMON,T.DE BEER,M.OVERDUINTITL SOLUTION STRUCTURE OF EPS15S THIRD EH DOMAINTITL 2 REVEALS COINCIDENT PHE-TRP AND ASN-PRO-PHE BINDINGTITL 3 SITES.REF BIOCHEMISTRY V. 39 4309 2000REFN ISSN 0006-2960PMID 10757979DOI 10.1021/BI9927383 Variant Set Distributions Mapped Variants
General Structure Information 1efv ETFB three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution 2.1Å AUTH D.L.ROBERTS,F.E.FRERMAN,J.J.KIMTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN ELECTRONTITL 2 TRANSFER FLAVOPROTEIN TO 2.1-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 93 14355 1996REFN ISSN 0027-8424PMID 8962055DOI 10.1073/PNAS.93.25.14355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bwg GMPR structure of human guanosine monophosphate reductase gmpr1 in complex with gmp 2.4Å AUTH G.BUNKOCZI,A.HARONITI,S.NG,F.VON DELFT,O.GILEADI,AUTH 2 U.OPPERMANN,C.ARROWSMITH,A.EDWARDS,M.SUNDSTROMTITL STRUCTURE OF HUMAN GUANOSINE MONOPHOSPHATE REDUCTASE GMPR1TITL 2 IN COMPLEX WITH GMPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lng NTS neurotensin 40 structures in dmpc:chaps:gm1(q= 0.25) bicelle ph 5.5 & 298k. nmr data & structures -1.0Å AUTH U.L.KHATUN,S.K.GOSWAMI,C.MUKHOPADHYAYTITL MODULATION OF THE NEUROTENSIN SOLUTION STRUCTURE IN THETITL 2 PRESENCE OF GANGLIOSIDE GM1 BICELLE.REF BIOPHYS.CHEM. V. 168 48 2012REFN ISSN 0301-4622PMID 22824320DOI 10.1016/J.BPC.2012.06.003 Variant Set Distributions Mapped Variants