Assessment of Structural Intolerance and Durability
General Structure Information 3rl7 DLG1 crytal structure of hdlg1-pdz1 complexed with apc 2.3Å AUTH Z.ZHANG,H.LI,L.CHEN,X.LU,J.ZHANG,P.XU,K.LIN,G.WUTITL MOLECULAR BASIS FOR THE RECOGNITION OF ADENOMATOUS POLYPOSISTITL 2 COLI BY THE DISCS LARGE 1 PROTEIN.REF PLOS ONE V. 6 23507 2011REFN ESSN 1932-6203PMID 21858148DOI 10.1371/JOURNAL.PONE.0023507 Variant Set Distributions Mapped Variants
General Structure Information 2yle SPIRE1 crystal structure of the human spir-1 kind fsi domain in complex with the fsi peptide 1.8Å AUTH K.ZETH,M.PECHLIVANIS,A.SAMOL,S.PLEISER,C.VONRHEIN,AUTH 2 E.KERKHOFFTITL MOLECULAR BASIS OF ACTIN NUCLEATION FACTOR COOPERATIVITY:TITL 2 CRYSTAL STRUCTURE OF THE SPIR-1 KINASE NON-CATALYTIC C-LOBETITL 3 DOMAIN (KIND)FORMIN-2 FORMIN SPIR INTERACTION MOTIF (FSI)TITL 4 COMPLEX.REF J.BIOL.CHEM. V. 286 30732 […]
General Structure Information 1k8f CAP1 crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein 2.8Å AUTH T.DODATKO,A.A.FEDOROV,M.GRYNBERG,Y.PATSKOVSKY,D.A.ROZWARSKI,AUTH 2 L.JAROSZEWSKI,E.ARONOFF-SPENCER,E.KONDRASKINA,T.IRVING,AUTH 3 A.GODZIK,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE ACTIN BINDING DOMAIN OF THETITL 2 CYCLASE-ASSOCIATED PROTEIN.REF BIOCHEMISTRY V. 43 10628 2004REFN ISSN 0006-2960PMID 15311924DOI 10.1021/BI049071R Variant Set Distributions Mapped Variants
General Structure Information 1k8f CAP1 crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein 2.8Å AUTH T.DODATKO,A.A.FEDOROV,M.GRYNBERG,Y.PATSKOVSKY,D.A.ROZWARSKI,AUTH 2 L.JAROSZEWSKI,E.ARONOFF-SPENCER,E.KONDRASKINA,T.IRVING,AUTH 3 A.GODZIK,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE ACTIN BINDING DOMAIN OF THETITL 2 CYCLASE-ASSOCIATED PROTEIN.REF BIOCHEMISTRY V. 43 10628 2004REFN ISSN 0006-2960PMID 15311924DOI 10.1021/BI049071R Variant Set Distributions Mapped Variants
General Structure Information 1k8f CAP1 crystal structure of the human c-terminal cap1-adenylyl cyclase associated protein 2.8Å AUTH T.DODATKO,A.A.FEDOROV,M.GRYNBERG,Y.PATSKOVSKY,D.A.ROZWARSKI,AUTH 2 L.JAROSZEWSKI,E.ARONOFF-SPENCER,E.KONDRASKINA,T.IRVING,AUTH 3 A.GODZIK,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE ACTIN BINDING DOMAIN OF THETITL 2 CYCLASE-ASSOCIATED PROTEIN.REF BIOCHEMISTRY V. 43 10628 2004REFN ISSN 0006-2960PMID 15311924DOI 10.1021/BI049071R Variant Set Distributions Mapped Variants
General Structure Information 1by2 LGALS3BP structure of m2bp scavenger receptor cysteine-rich domain 2.0Å AUTH E.HOHENESTER,T.SASAKI,R.TIMPLTITL CRYSTAL STRUCTURE OF A SCAVENGER RECEPTOR CYSTEINE-RICHTITL 2 DOMAIN SHEDS LIGHT ON AN ANCIENT SUPERFAMILY.REF NAT.STRUCT.BIOL. V. 6 228 1999REFN ISSN 1072-8368PMID 10074941DOI 10.1038/6669 Variant Set Distributions Mapped Variants
General Structure Information 4a11 ERCC8 structure of the hsddb1-hscsa complex 3.31Å AUTH E.S.FISCHER,A.SCRIMA,K.BOHM,S.MATSUMOTO,G.M.LINGARAJU,AUTH 2 M.FATY,T.YASUDA,S.CAVADINI,M.WAKASUGI,F.HANAOKA,S.IWAI,AUTH 3 H.GUT,K.SUGASAWA,N.H.THOMATITL THE MOLECULAR BASIS OF CRL4(DDB2/CSA) UBIQUITIN LIGASETITL 2 ARCHITECTURE, TARGETING, AND ACTIVATION.REF CELL(CAMBRIDGE,MASS.) V. 147 1024 2011REFN ISSN 0092-8674PMID 22118460DOI 10.1016/J.CELL.2011.10.035 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2c74 YWHAH 14-3-3 protein eta (human) complexed to peptide 2.7Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yjr ATP7A solution structure of the apo form of the sixth soluble domain a69p mutant of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,A.ROSATO,AUTH 2 S.WANGTITL AN ATOMIC-LEVEL INVESTIGATION OF THETITL 2 DISEASE-CAUSING A629P MUTANT OF THE MENKESTITL 3 PROTEIN, ATP7AREF J.MOL.BIOL. V. 352 409 2005REFN ISSN 0022-2836PMID 16083905DOI 10.1016/J.JMB.2005.07.034 Variant Set Distributions Mapped Variants
General Structure Information 1yjr ATP7A solution structure of the apo form of the sixth soluble domain a69p mutant of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,F.CANTINI,M.MIGLIARDI,A.ROSATO,AUTH 2 S.WANGTITL AN ATOMIC-LEVEL INVESTIGATION OF THETITL 2 DISEASE-CAUSING A629P MUTANT OF THE MENKESTITL 3 PROTEIN, ATP7AREF J.MOL.BIOL. V. 352 409 2005REFN ISSN 0022-2836PMID 16083905DOI 10.1016/J.JMB.2005.07.034 Variant Set Distributions Mapped Variants